Age at onset and visuocognitive disturbances in Alzheimer disease.
Abstract
We examined the relation of age at onset and visuocognitive disturbances in Alzheimer disease (AD) using a large sample of patients, quantitative neuropsychological measures, and multivariate statistics controlling for gender, education, stage of dementia, and disease duration. Significant positive coefficients were obtained with forward and backward digit and visual spans, visual counting, copying Rey complex figure, and block design task. The results indicated that patients with early-onset AD performed worse than late-onset AD patients on these tasks. There was no significant effect of age at onset on identification of overlapping figures, visual form discrimination, or Raven's colored progressive matrices. These findings confirm the greater attentional and visuospatial impairments in early onset patients when these confounding factors were controlled for, although no significant effect of age at onset in visuoperceptual function was observed.
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EOAD patients exhibit a wider range of cognitive dysfunction, including non-memory cognitive domains, than LOAD patients.
“while EOAD patients exhibit a wider range of cognitive dysfunction, which can also include non-memory cognitive domains (Fujimori et al., 1998; Kaiser et al., 2012; Smits et al., 2012).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Fujimori et al., 1998
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Duara, R., & Barker, W. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01185-z · Cited by 187 · see citing works
Early onset Alzheimer’s disease is associated with a distinct neuropsychological profile
Smits, L. L., Pijnenburg, Y. A. L., Koedam, E. L. G. E., van der Vlies, A. E., Reuling, I. E. W., Koene, T., Teunissen, C. E., Scheltens, P., & van der Flier, W. M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111934 · Cited by 182 · see citing works
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Polsinelli, A. J., & Apostolova, L. G. (2022) · Continuum · doi:10.1212/con.0000000000001082 · Cited by 39 · see citing works
Lee, W. J., Yoon, C. W., Kim, S.-W., Jeong, H. J., Seo, S., Na, D. L., Noh, Y., & Seong, J.-K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.606600 · Cited by 12 · see citing works
- Authors
- Fujimori, M., Imamura, T., Yamashita, H., Hirono, N., Ikejiri, Y., Shimomura, T., & Mori, E.
- Venue
- Alzheimer Disease & Associated Disorders
- Published
- 1998-09
- Volume
- 12
- Issue
- 3
- Pages
- 163-166
- ISSN
- 0893-0341 (ISSN-L)
- OpenAlex
- W2063629105
- Cited by
- 72
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 7
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer Disease & Associated Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- Alzheimer's disease, age of onset, early-onset Alzheimer's disease, late-onset Alzheimer's disease, visuospatial impairment, attention, digit span, visual span, visual counting, Rey Complex Figure, block designs, visual form discrimination, Coloured Progressive Matrices
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Attention, Cognition Disorders, Discrimination Learning, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Perceptual Disorders, Problem Solving, Psychometrics, Mental Recall, Visual Perception
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