Early onset Alzheimer’s disease is associated with a distinct neuropsychological profile
Abstract
Alzheimer's disease (AD) in younger patients is associated with a higher prevalence of atypical symptoms. We examined neuropsychological performance according to age-at-onset. We assessed cognition in 172 patients with AD (81 early and 91 late onset) in five cognitive domains (memory, language, visuo-spatial functioning, executive functioning, attention). Dementia severity was assessed using the Mini-Mental State Examination (MMSE) and global cognitive decline using Cambridge Cognitive Examination (CAMCOG). Analyses of variance were performed with age-at-onset as between-subjects factor, and gender and education as covariates. Analysis was repeated after stratification for dementia severity (based on median MMSE). In early onset AD, age (mean ± SD) was 60 ± 4 years; 44 (54%) were female. In late onset AD, age was 72 ± 5 years; 47 (52%) were female. Dementia severity and global cognitive decline did not differ between groups (early onset: MMSE: 20 ± 5, CAMCOG: 69 ± 15, late onset: MMSE: 21 ± 5, CAMCOG: 70 ± 15; p > 0.05). Early onset patients performed worse than late onset patients on visuo-spatial functioning (p < 0.01), executive functioning (p < 0.001), and attention (p < 0.01). Late onset patients performed worse on memory, although not significantly (p = 0.11). Stratification for dementia severity showed that in mildly demented early onset patients, memory function was remarkably preserved compared to late onset patients (p < 0.01). In moderate AD, differences in memory function disappeared, but early onset patients performed worse on visuo-spatial functioning (p < 0.01), executive functioning (p < 0.001), and attention (p < 0.01) than late onset patients. Adjustment for APOE left results unchanged. In conclusion, early onset AD presents with a different cognitive profile and the disease course seems different. Relative sparing of memory function in early stages stresses the need to adequately test other cognitive domains.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Memory function is generally more disrupted in LOAD patients than in EOAD patients.
“memory function is generally more disrupted in LOAD patients (Jacobs et al., 1994; Koss et al., 1996; Smits et al., 2012)”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Smits et al., 2012
EOAD patients exhibit a wider range of cognitive dysfunction, including non-memory cognitive domains, than LOAD patients.
“while EOAD patients exhibit a wider range of cognitive dysfunction, which can also include non-memory cognitive domains (Fujimori et al., 1998; Kaiser et al., 2012; Smits et al., 2012).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Smits et al., 2012
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 7,925 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
L’examen Clinique en Psychologie
Rubé, P. (1959) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1959.13.4.989 · Cited by 3,299 · see citing works
Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70156-9 · Cited by 972 · see citing works
Galton, C. J. (2000) · Brain · doi:10.1093/brain/123.3.484 · Cited by 613 · see citing works
Early-Versus Late-Onset Alzheimer's Disease: More than Age Alone
Koedam, E. L. G. E., Lauffer, V., van der Vlies, A. E., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1337 · Cited by 452 · see citing works
The topography of grey matter involvement in early and late onset Alzheimer's disease
Frisoni, G. B., Pievani, M., Testa, C., Sabattoli, F., Bresciani, L. C., Bonetti, M., Beltramello, A., Hayashi, K. M., Toga, A. W., & Thompson, P. M. (2007) · Brain · doi:10.1093/brain/awl377 · Cited by 433 · see citing works
Visual assessment of posterior atrophy development of a MRI rating scale
Koedam, E., Lehmann, M., van der Flier, W. M., Scheltens, P., Pijnenburg, Y. A. L., Fox, N. C., Barkhof, F., & Wattjes, M. P. (2011) · European Radiology · doi:10.1007/s00330-011-2205-4 · Cited by 410 · see citing works
A Comparison of Clinical Features in Early- and Late-Onset Primary Degenerative Dementia
Seltzer, B. (1983) · Archives of Neurology · doi:10.1001/archneur.1983.04050030037006 · Cited by 365 · see citing works
Visual association test to detect early dementia of the Alzheimer type
Lindeboom, J. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.2.126 · Cited by 359 · see citing works
Mulder, C., Verwey, N. A., van der Flier, W. M., Bouwman, F. H., Kok, A., van Elk, E. J., Scheltens, P., & Blankenstein, M. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.130518 · Cited by 332 · see citing works
Clinical subtypes of dementia of the Alzheimer type
Chui, H. C., Teng, E. L., Henderson, V. W., & Moy, A. C. (1985) · Neurology · doi:10.1212/wnl.35.11.1544 · Cited by 296 · see citing works
Precuneus atrophy in early-onset Alzheimer’s disease: a morphometric structural MRI study
Karas, G. B., Scheltens, P., Rombouts, S. A. R. B., van Schijndel, R. A., Klein, M., Jones, B. F., van der Flier, W. M., Vrenken, H., & Barkhof, F. (2007) · Neuroradiology · doi:10.1007/s00234-007-0269-2 · Cited by 292 · see citing works
Jacobs, D., Sano, M., Marder, K., Bell, K., Bylsma, F., Lafleche, G., Albert, M., Brandt, J., & Stern, Y. (1994) · Neurology · doi:10.1212/wnl.44.7.1215 · Cited by 266 · see citing works
Letterfluency: psychometrische eigenschappen en Nederlandse normen
Schmand, B. A., Groenink, S. C., & den Dungen, M. (2008) · Tijdschrift voor Gerontologie en Geriatrie · doi:10.1007/bf03078128 · Cited by 212 · see citing works
Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease.
Ross, S. J., Graham, N. L., Stuart-Green, L., Prins, M., Xuereb, J. H., Patterson, K. E., & Hodges, J. R. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.4.388 · Cited by 177 · see citing works
Koss, E., Edland, S., Fillenbaum, G., Mohs, R., Clark, C., Galasko, D., & Morris, J. C. (1996) · Neurology · doi:10.1212/wnl.46.1.136 · Cited by 150 · see citing works
The effect of APOE genotype on clinical phenotype in Alzheimer disease
van der Flier, W. M., Schoonenboom, S. N. M., Pijnenburg, Y. A. L., Fox, N. C., & Scheltens, P. (2006) · Neurology · doi:10.1212/01.wnl.0000228222.17111.2a · Cited by 98 · see citing works
Lehmann, M., Koedam, E., Barnes, J., Bartlett, J. W., Ryan, N. S., Pijnenburg, Y. A. L., Barkhof, F., Wattjes, M. P., Scheltens, P., & Fox, N. C. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.04.003 · Cited by 96 · see citing works
Age at Onset and Pattern of Neuropsychological Impairment in Mild Early-Stage Alzheimer Disease
Reid, W. G. J. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550100142023 · Cited by 95 · see citing works
Grady, C. L., Haxby, J. V., Horwitz, B., Berg, G., & Рапопорт, С. И. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90118-7 · Cited by 93 · see citing works
Toyota, Y., Ikeda, M., Shinagawa, S., Matsumoto, T., Matsumoto, N., Hokoishi, K., Fukuhara, R., Ishikawa, T., Mori, T., Adachi, H., et al. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1760 · Cited by 90 · see citing works
Presenile dementia syndromes: an update on taxonomy and diagnosis
Greicius, M. D. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.691 · Cited by 85 · see citing works
Derix, M. M. A., Hofstede, A. B., Teunisse, S., Hijdra, A., Walstra, G. J. M., Weinstein, H. C., & van Gool, W. A. (1991) · PubMed · Cited by 73 · see citing works
Age at onset and visuocognitive disturbances in Alzheimer disease.
Fujimori, M., Imamura, T., Yamashita, H., Hirono, N., Ikejiri, Y., Shimomura, T., & Mori, E. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00007 · Cited by 72 · see citing works
[Digit series and Knox cubes as concentration tests for elderly subjects].
Lindeboom, J., & Matto, D. (1994) · PubMed · Cited by 56 · see citing works
Language dysfunction in early‐ and late‐onset possible Alzheimer's disease
Seines, O. A., Carson, K. A., Rovner, B. W., & Gordon, B. (1988) · Neurology · doi:10.1212/wnl.38.7.1053 · Cited by 51 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease
Ossenkoppele, R., Schonhaut, D. R., Schöll, M., Lockhart, S. N., Ayakta, N., Baker, S. L., O’Neil, J. P., Janabi, M., Lazaris, A., Cantwell, A., et al. (2016) · Brain · doi:10.1093/brain/aww027 · Cited by 1,185 · see citing works
Brain atrophy in Alzheimer’s Disease and aging
Pini, L., Pievani, M., Bocchetta, M., Altomare, D., Bosco, P., Cavedo, E., Galluzzi, S., Marizzoni, M., & Frisoni, G. B. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.002 · Cited by 874 · see citing works
Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
Tijms, B. M., Wink, A. M., de Haan, W., van der Flier, W. M., Stam, C. J., Scheltens, P., & Barkhof, F. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.020 · Cited by 416 · see citing works
Self-citationAmsterdam Dementia Cohort: Performing Research to Optimize Care
van der Flier, W. M., & Scheltens, P. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170850 · Cited by 379 · see citing works
Mendez, M. F. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.005 · Cited by 356 · see citing works
Ossenkoppele, R., Cohn‐Sheehy, B. I., La Joie, R., Vogel, J. W., Möller, C., Lehmann, M., van Berckel, B. N. M., Seeley, W. W., Pijnenburg, Y. A., Gorno‐Tempini, M. L., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22927 · Cited by 243 · see citing works
The paradox of syndromic diversity in Alzheimer disease
Warren, J. D., Fletcher, P. D., & Golden, H. L. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.135 · Cited by 197 · see citing works
Different patterns of gray matter atrophy in early- and late-onset Alzheimer’s disease
Möller, C., Vrenken, H., Jiskoot, L. C., Versteeg, A., Barkhof, F., Scheltens, P., & van der Flier, W. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.013 · Cited by 183 · see citing works
Rate of early onset Alzheimer's disease: a systematic review and meta-analysis.
Zhu, X., Tan, L., Wang, H.-F., Jiang, T., Cao, L., Wang, C., Wang, J., Tan, C., Meng, X., & Yu, J. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.01.19 · Cited by 179 · see citing works
Early-onset Alzheimer's Disease: Nonamnestic Subtypes and Type 2 AD
Mendez, M. F. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.11.009 · Cited by 167 · see citing works
Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
Barnes, J., Dickerson, B. C., Frost, C. D., Jiskoot, L. C., Wolk, D. A., & van der Flier, W. M. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.12.007 · Cited by 152 · see citing works
The role of egocentric and allocentric abilities in Alzheimer's disease: A systematic review
Serino, S., Cipresso, P., Morganti, F., & Riva, G. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.04.004 · Cited by 129 · see citing works
Functional connectivity changes differ in early and late-onset alzheimer's disease
Gour, N., Félician, O., Didic, M., Koric, L., Guériot, C., Chanoine, V., Sylviane Confort-gouny, A., Guye, M., Ceccaldi, M. P., & Ranjeva, J. (2013) · Human Brain Mapping · doi:10.1002/hbm.22379 · Cited by 129 · see citing works
Genetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works
“have traditionally been considered distinct [29, 30], this review will consider the underlying genetic architecture of both forms of the disease, which in recent years has come to highlight a significant overlap between the subtypes.”
Lehmann, M., Madison, C. M., Ghosh, P. M., Seeley, W. W., Mormino, E., Greicius, M. D., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L., Jagust, W. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221536110 · Cited by 122 · see citing works
Brain network connectivity differs in early-onset neurodegenerative dementia
Filippi, M., Basaia, S., Canu, E., Imperiale, F., Meani, A., Caso, F., Magnani, G., Falautano, M., Comı, G., Falini, A., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004577 · Cited by 120 · see citing works
Diagnostic impact of [18F]flutemetamol PET in early-onset dementia
Zwan, M. D., Bouwman, F. H., Konijnenberg, E., van der Flier, W. M., Lammertsma, A. A., Verhey, F. R. J., Aalten, P., van Berckel, B. N. M., & Scheltens, P. (2017) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0228-4 · Cited by 118 · see citing works
Lorenzo, F. D., Ponzo, V., Bonnı̀, S., Motta, C., Serra, P. C. N., Bozzali, M., Caltagirone, C., Martorana, A., & Koch, G. (2016) · Annals of Neurology · doi:10.1002/ana.24695 · Cited by 110 · see citing works
Joubert, S., Gour, N., Guedj, É., Didic, M., Guériot, C., Koric, L., Ranjeva, J., Félician, O., Guye, M., & Ceccaldi, M. P. (2015) · Cortex · doi:10.1016/j.cortex.2015.10.014 · Cited by 109 · see citing works
Tondo, G., Iaccarino, L., Caminiti, S. P., Presotto, L., Santangelo, R., Iannaccone, S., Magnani, G., & Perani, D. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00619-0 · Cited by 107 · see citing works
Möller, C., Pijnenburg, Y. A. L., van der Flier, W. M., Versteeg, A., Tijms, B., de Munck, J. C., Hafkemeijer, A., Rombouts, S. A. R. B., van der Grond, J., van Swieten, J., et al. (2016) · Radiology · doi:10.1148/radiol.2015150220 · Cited by 103 · see citing works
Self-citationVisuospatial Perception: An Emerging Biomarker for Alzheimer's Disease
Mandal, P. K., Joshi, J., & Saharan, S. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120901 · Cited by 96 · see citing works
Verclytte, S., Lopes, R., Lenfant, P., Rollin, A., Semah, F., Leclerc, X., Pasquier, F., & Delmaire, C. (2015) · Journal of Neuroimaging · doi:10.1111/jon.12264 · Cited by 93 · see citing works
Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer’s disease
Tanner, J. A., Iaccarino, L., Edwards, L., Asken, B. M., Gorno‐Tempini, M. L., Kramer, J. H., Pham, J. Q., Perry, D. C., Possin, K. L., Malpetti, M., et al. (2022) · Brain · doi:10.1093/brain/awac229 · Cited by 88 · see citing works
Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer’s Disease
Migliaccio, R., Agosta, F., Possin, K. L., Canu, E., Filippi, M., Rabinovici, G. D., Rosen, H. J., Miller, B. L., & Gorno‐Tempini, M. L. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142292 · Cited by 91 · see citing works
Differences between early and late onset Alzheimer's disease.
Panegyres, P. K., & Chen, H.-Y. (2013) · Europe PMC (PubMed Central) · Cited by 88 · see citing works
Palasí, A., Gutiérrez-Iglesias, B., Alegret, M., Pujadas, F., Olabarrieta, M., Liébana, D., Quintana, M., Álvarez‐Sabín, J., & Boada, M. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7698-3 · Cited by 84 · see citing works
Enfermedad de Alzheimer de inicio precoz y de inicio tardío: ¿son la misma entidad?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2015) · Neurología · doi:10.1016/j.nrl.2015.08.002 · Cited by 86 · see citing works
Cho, H., Choi, J. Y., Lee, S. H., Lee, J. H., Choi, Y.-C., Ryu, Y. H., Lee, M. S., & Lyoo, C. H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.024 · Cited by 83 · see citing works
Micanovic, C., & Pal, S. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1070-5 · Cited by 80 · see citing works
Early- and late-onset Alzheimer disease: Are they the same entity?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.08.009 · Cited by 81 · see citing works
Changes in subcortical structures in early- versus late-onset Alzheimer's disease
Cho, H., Seo, S. W., Kim, J. H., Kim, C., Ye, B. S., Kim, G. H., Noh, Y., Kim, H. J., Yoon, C. W., Seong, J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.001 · Cited by 79 · see citing works
Detecting frontotemporal dementia syndromes using MRI biomarkers
Bruun, M., Koikkalainen, J., Rhodius-Meester, H., Baroni, M., Gjerum, L., van Gils, M., Soininen, H., Remes, A., Hartikainen, P., Waldemar, G., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101711 · Cited by 66 · see citing works
Ossenkoppele, R., Mattsson, N., Teunissen, C. E., Barkhof, F., Pijnenburg, Y. A. L., Scheltens, P., van der Flier, W. M., & Rabinovici, G. D. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.011 · Cited by 71 · see citing works
White Matter Degeneration in Atypical Alzheimer Disease
Caso, F., Agosta, F., Mattavelli, D., Migliaccio, R., Canu, E., Magnani, G., Marcone, A., Copetti, M., Falautano, M., Comı, G., et al. (2015) · Radiology · doi:10.1148/radiol.2015142766 · Cited by 69 · see citing works
Özbek, Y., Fide, E., & Yener, G. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.05.012 · Cited by 69 · see citing works
Koychev, I. G., on behalf of the Deep and Frequent Phenotyping study team (http://www.dementiastudy.co.uk/), Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B. J., Rowe, J. B., Thomas, A. J., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170129 · Cited by 67 · see citing works
Neuropsychological and neuroimaging markers in early versus late-onset Alzheimer’s disease.
Kaiser, N. C., Melrose, R. J., Liu, C., Sultzer, D. L., Jimenez, E., Su, M., Monserratt, L., & Mendez, M. F. (2012) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317512459798 · Cited by 68 · see citing works
Medial temporal atrophy in early and late-onset Alzheimer's disease
Cavedo, E., Pievani, M., Boccardi, M., Galluzzi, S., Bocchetta, M., Bonetti, M., Thompson, P. M., & Frisoni, G. B. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.009 · Cited by 67 · see citing works
Tijms, B. M., Yeung, H. M., Sikkes, S. A. M., Möller, C., Smits, L. L., Stam, C. J., Scheltens, P., van der Flier, W. M., & Barkhof, F. (2014) · Brain Connectivity · doi:10.1089/brain.2013.0209 · Cited by 65 · see citing works
Lasaponara, S., Marson, F., Doricchi, F., & Cavallo, M. (2021) · Brain Science · doi:10.3390/brainsci11050528 · Cited by 54 · see citing works
Mouton‐Liger, F., Wallon, D., Troussière, A., Yatimi, R., Dumurgier, J., Magnin, É., Sayette, V. D. L., Duron, E., Philippi, N., Beaufils, É., et al. (2013) · Journal of Neurology · doi:10.1007/s00415-013-7160-3 · Cited by 67 · see citing works
Differences in Anxiety Among Patients With Early- Versus Late-Onset Alzheimer’s Disease
Kaiser, N. C., Liang, L.-J. F., Melrose, R. J., Wilkins, S. S., Sultzer, D. L., & Mendez, M. F. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12100240 · Cited by 66 · see citing works
Ballarini, T., Iaccarino, L., Magnani, G., Ayakta, N., Miller, B. L., Jagust, W. J., Gorno‐Tempini, M., Rabinovici, G. D., & Perani, D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23305 · Cited by 65 · see citing works
Widespread Disruption of Functional Brain Organization in Early-Onset Alzheimer’s Disease
Adriaanse, S. M., Binnewijzend, M. A. A., Ossenkoppele, R., Tijms, B. M., van der Flier, W. M., Koene, T., Smits, L. L., Wink, A. M., Scheltens, P., van Berckel, B. N. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102995 · Cited by 64 · see citing works
Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study
Pievani, M., Bocchetta, M., Boccardi, M., Cavedo, E., Bonetti, M., Thompson, P. M., & Frisoni, G. B. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.016 · Cited by 62 · see citing works
Canu, E., Agosta, F., Mandic-Stojmenovic, G., Stojković, T., Stefanova, E., Inuggi, A., Imperiale, F., Copetti, M., Kostic, V. S., & Filippi, M. (2017) · NeuroImage: Clinical · doi:10.1016/j.nicl.2017.05.018 · Cited by 62 · see citing works
Rural-Urban Disparities in Diagnosis of Early-Onset Dementia
Xu, W., Jung, J. K., Retchin, S. M., Li, Y., & Roy, S. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.25805 · Cited by 60 · see citing works
Henneges, C., Reed, C. C., Chen, Y.-F., Dell’Agnello, G., & Lebrec, J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150852 · Cited by 59 · see citing works
Möller, C., Dieleman, N., van der Flier, W. M., Versteeg, A., Pijnenburg, Y. A. L., Scheltens, P., Barkhof, F., & Vrenken, H. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141230 · Cited by 58 · see citing works
Smits, L. L., Pijnenburg, Y. A. L., van der Vlies, A. E., Koedam, E., Bouwman, F. H., Reuling, I. E. W., Scheltens, P., & van der Flier, W. M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.03.014 · Cited by 58 · see citing works
Costa, A. S., Reich, A., Fimm, B., Ketteler, S. T., Schulz, J. B., & Reetz, K. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000351864 · Cited by 57 · see citing works
Tort‐Merino, A., Falgàs, N., Allen, I. E., Balasa, M., Olives, J., Contador, J., Castellví, M., Juncà‐Parella, J., Guillén, N., Borrego‐Écija, S., et al. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51689 · Cited by 55 · see citing works
Möller, C., Hafkemeijer, A., Pijnenburg, Y. A. L., Rombouts, S. A. R. B., van der Grond, J., Dopper, E. G. P., Swieten, J. C. V., Versteeg, A., Pouwels, P. J. W., Barkhof, F., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.08.022 · Cited by 52 · see citing works
Kamath, V., Sutherland, E. R., & Chaney, G.-A. (2020) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617719001115 · Cited by 51 · see citing works
Neuroimaging in aging and neurologic diseases
Risacher, S. L., & Saykin, A. J. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00012-1 · Cited by 54 · see citing works
The Rest-Activity Rhythm and Physical Activity in Early-Onset Dementia
Hooghiemstra, A. M., Eggermont, L. H. P., Scheltens, P., van der Flier, W. M., & Scherder, E. (2014) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000037 · Cited by 50 · see citing works
Möller, C., Hafkemeijer, A., Pijnenburg, Y. A. L., Rombouts, S. A. R. B., van der Grond, J., Dopper, E. G. P., Swieten, J. C. V., Versteeg, A., Steenwijk, M. D., Barkhof, F., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.020 · Cited by 48 · see citing works
Caso, F., Agosta, F., & Filippi, M. (2015) · Neurodegenerative Diseases · doi:10.1159/000441422 · Cited by 47 · see citing works
Neuropsychological differentiation of progressive aphasic disorders
Harris, J. M., Saxon, J. A., Jones, M., Snowden, J. S., & Thompson, J. C. (2019) · Journal of Neuropsychology · doi:10.1111/jnp.12149 · Cited by 47 · see citing works
van Rooden, S., Doan, N. T., Versluis, M. J., Goos, J. D. C., WEBB, A. G., Oleksik, A. M., van der Flier, W. M., Scheltens, P., Barkhof, F., Weverling‐Rynsburger, A. W. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.006 · Cited by 47 · see citing works
Smits, L. L., Flapper, M., Sistermans, N., Pijnenburg, Y. A. L., Scheltens, P., & van der Flier, W. M. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000358168 · Cited by 45 · see citing works
Chiaravalloti, A., Koch, G., Toniolo, S., Belli, L., Lorenzo, F. D., Gaudenzi, S., Schillaci, O., Bozzali, M., Sancesario, G., & Martorana, A. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000441776 · Cited by 45 · see citing works
Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease
Gumus, M., Multani, N., Mack, M. L., Tartaglia, M. C., & Initiative, A. D. N. (2021) · GeroScience · doi:10.1007/s11357-020-00304-y · Cited by 45 · see citing works
Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer’s Disease
Baillon, S. F., Gasper, A. V., Wilson-Morkeh, F., Pritchard, M., Jesu, A. J. M., & Velayudhan, L. (2019) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317519841191 · Cited by 44 · see citing works
White matter microstructural damage in Alzheimer's disease at different ages of onset
Canu, E., Agosta, F., Spinelli, E. G., Magnani, G., Marcone, A., Scola, E., Falautano, M., Comi, G., Falini, A., & Filippi, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.026 · Cited by 42 · see citing works
Sánchez, S. M., Abulafia, C., Duarte-Abritta, B., Guevara, M., Castro, M. N., Drucaroff, L. J., Sevlever, G. E., Nemeroff, C. B., Vigo, D. E., Loewenstein, D., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170491 · Cited by 42 · see citing works
The Role of Ethnicity in Alzheimer’s Disease: Findings From The C-PATH Online Data Repository
Chen, H.-Y., & Panegyres, P. K. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151089 · Cited by 42 · see citing works
Thalamic nuclei changes in early and late onset Alzheimer's disease
Forno, G., Saranathan, M., Contador, J., Guillen, N., Falgàs, N., Tort-Merino, A., Balasa, M., Sanchez-Valle, R., Hornberger, M., & Lladó, A. (2023) · Current Research in Neurobiology · doi:10.1016/j.crneur.2023.100084 · Cited by 39 · see citing works
Wu, S., Zhan, P., Wang, G., Yu, X., Liu, H., & Wang, W. (2024) · BMC Neuroscience · doi:10.1186/s12868-024-00877-w · Cited by 39 · see citing works
Park, H. K., Choi, S. H., Park, S. A., Kim, H. J., Lee, Y., Han, S., Kim, E., Kim, B. C., Han, H. J., Moon, S. Y., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141011 · Cited by 38 · see citing works
Glucose Metabolic Brain Networks in Early-Onset vs. Late-Onset Alzheimer's Disease
Chung, J., Yoo, K., Kim, E., Na, D. L., & Jeong, Y. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00159 · Cited by 36 · see citing works
Vanhoutte, M., Semah, F., Sillaire, A. R., Jaillard, A., Petyt, G., Kuchcinski, G., Maureille, A., Delbeuck, X., Fahmi, R., Pasquier, F., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.009 · Cited by 37 · see citing works
Heritability in frontotemporal dementia: more missing pieces?
Po, K., Leslie, F. V. C., Gracia, N., Bartley, L., Kwok, J. B., Halliday, G. M., Hodges, J. R., & Burrell, J. R. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7474-9 · Cited by 33 · see citing works
A New Perspective on Alzheimer’s Disease as a Brain Expression of a Complex Metabolic Disorder
Polis, B., & Samson, A. O. (2019) · Codon Publications eBooks · doi:10.15586/alzheimersdisease.2019.ch1 · Cited by 32 · see citing works
Carr, A. R., Paholpak, P., Daianu, M., Fong, S. S., Mather, M. J., Jimenez, E. E., Thompson, P. M., & Mendez, M. F. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.09.033 · Cited by 31 · see citing works
Pang, R. C. K., & Lee, D. (2017) · Dementia · doi:10.1177/1471301217724026 · Cited by 30 · see citing works
Levy, S. R., & Apriceno, M. (2019) · OBM Geriatrics · doi:10.21926/obm.geriatr.1904083 · Cited by 32 · see citing works
Stage, E., Svaldi, D. O., Phillips, M. L., Canela, V. H., Duran, T., Goukasian, N., Risacher, S. L., Saykin, A. J., Apostolova, L. G., & Initiative, A. D. N. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00647-w · Cited by 30 · see citing works
Understanding the world of dementia. How do people with dementia experience the world?
Zwijsen, S. A., van der Ploeg, E., & Hertogh, C. M. P. M. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216000351 · Cited by 30 · see citing works
Kim, K. W., Lee, S. Y., Choi, J. D., Chin, J., Lee, B. H., Na, D. L., & Choi, J. H. (2020) · Journal of Medical Internet Research · doi:10.2196/18136 · Cited by 27 · see citing works
Li, K., Luo, X., Zeng, Q., Xu, X., Huang, P., Shen, Z., Xu, J., Zhou, J., & Zhang, M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00261 · Cited by 27 · see citing works
de Boer, C., Mattace-Raso, F. U. S., van der Steen, J., & Pel, J. J. M. (2013) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12183 · Cited by 25 · see citing works
Peng, G., Wang, J., Feng, Z., Liu, P., Zhang, Y., He, F., Chen, Z., Zhao, K., & Luo, B. (2016) · Scientific Reports · doi:10.1038/srep29372 · Cited by 25 · see citing works
van der Vlies, A. E., Staekenborg, S. S., Behloul, F., Prins, N. D., Barkhof, F., Vrenken, H., Reiber, J. H. C., Scheltens, P., & van der Flier, W. M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121291 · Cited by 24 · see citing works
Pini, L., Geroldi, C., Galluzzi, S., Baruzzi, R., Bertocchi, M., Chitò, E., Orini, S., Romano, M., Cotelli, M., Rosini, S., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00212-6 · Cited by 25 · see citing works
Salem, L. C., Vogel, A., Ebstrup, J. F., Linneberg, A. R., & Waldemar, G. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4272 · Cited by 23 · see citing works
Salem, L. C., Andersen, B. B., Nielsen, T. R., Stokholm, J., Jørgensen, M. B., & Waldemar, G. (2014) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000358050 · Cited by 22 · see citing works
Diagnostic Accuracy of MRI Visual Rating Scales in the Diagnosis of Early Onset Cognitive Impairment
Falgàs, N., Balasa, M., Bargalló, N., Borrego‐Écija, S., Ramos‐Campoy, O., Fernández‐Villullas, G., Bosch, B., Olives, J., Tort‐Merino, A., Antonell, A., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191167 · Cited by 22 · see citing works
Predictive Factors for Disease Progression in Patients With Early-Onset Alzheimer’s Disease
Yoon, B., Shim, Y. S., Park, H. K., Park, S. A., Choi, S. H., & Yang, D. W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150462 · Cited by 22 · see citing works
Marson, F., Lasaponara, S., & Cavallo, M. (2021) · Medicina · doi:10.3390/medicina57030215 · Cited by 22 · see citing works
Visser, D., Verfaillie, S. C. J., Wolters, E. E., Coomans, E. M., Timmers, T., Tuncel, H., Boellaard, R., Golla, S. S. V., Windhorst, A. D., Scheltens, P., et al. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05669-6 · Cited by 19 · see citing works
Lee, E.-C., Kang, J. M., Seo, S., Seo, H., Lee, S., Park, K. H., Na, D. L., Noh, Y., & Seong, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.563559 · Cited by 19 · see citing works
Prawiroharjo, P., Yamashita, K., Yamashita, K., Togao, O., Hiwatashi, A., Yamasaki, R., & Kira, J. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04516 · Cited by 20 · see citing works
Posterior Cingulate Cortex Hypometabolism in Non-Amnestic Variants of Alzheimer’s Disease
Bergeron, D., Beauregard, J., Jean-Guimond, Soucy, J., Verret, L., Poulin, S. P., Matías‐Guiu, J. A., Cabrera‐Martín, M. N., Bouchard, R. W., & Laforce, R. J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200567 · Cited by 20 · see citing works
Llibre‐Guerra, J. J., Iaccarino, L., Coble, D., Edwards, L., Li, Y., McDade, E., Strom, A., Gordon, B. A., Mundada, N. S., Schindler, S. E., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad280 · Cited by 19 · see citing works
Distinct fiber-specific white matter reductions pattern in early- and late-onset Alzheimer’s disease
Luo, X., Wang, S.-Y., Jiaerken, Y., Li, K.-C., Zeng, Q.-Z., Hong, H., Guan, X.-J., Guo, T., Wang, C., Zhang, R.-T., et al. (2020) · Aging · doi:10.18632/aging.202702 · Cited by 17 · see citing works
Lee, W. J., Cho, H., Baek, M. S., Kim, H., Lee, J., Ryu, Y. H., Lyoo, C. H., & Seong, J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01061-0 · Cited by 20 · see citing works
Bertoux, M., Cassagnaud, P., Lebouvier, T., Sarazin, M., Ber, I. L., Dubois, B., Duyckaerts, C., Auriacombe, S., Hannequin, D., Ceccaldi, M., et al. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-190124 · Cited by 17 · see citing works
Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer’s Disease
Hirano, S., Shinotoh, H., Shimada, H., Ota, T., Sato, K., Tanaka, N., Zhang, M., Higuchi, M., Fukushi, K., Irie, T., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170749 · Cited by 17 · see citing works
- Authors
- Smits, L. L., Pijnenburg, Y. A. L., Koedam, E. L. G. E., van der Vlies, A. E., Reuling, I. E. W., Koene, T., Teunissen, C. E., Scheltens, P., & van der Flier, W. M.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2012-05-04
- Volume
- 30
- Issue
- 1
- Pages
- 101-108
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1570778022
- Cited by
- 182
- References
- 31
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 10 · 2020: 18 · 2019: 11 · 2018: 9 · 2017: 14 · 2016: 13 · 2015: 26 · 2014: 13 · 2013: 18 · 2012: 4
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Vanderbilt University Medical Center
- Stichting Dioraphte
- Alzheimer Nederland
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- early-onset Alzheimer's disease, late-onset Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Attention, Cognition Disorders, Dementia, Female, Humans, Language, Male, Memory, Mental Status Schedule, Mutation, Neuropsychological Tests, Retrospective Studies, Space Perception, Age of Onset, Presenilin-1, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
