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Induction of Cytokine Production from Human Monocytes Stimulated with Alginate
Abstract
Alginates are polysaccharides with gel-forming properties composed of 1,4-linked beta-D-mannuronic acid (M), alpha-L-guluronic acid (G), and alternating (MG) blocks. Alginate can be used as a matrix for implanted cells in vivo. In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1. Alginates stimulated the monocytes to produce high levels of all three cytokines. Low G alginates were approximately 10 times more potent in inducing cytokine production compared with high G alginates. The M-blocks and the MG-blocks, but not the G-blocks, stimulated the cytokine production. The results demonstrate that the mannuronic acid residues are the active cytokine inducers in alginates.
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Wong, T. Y., Preston, L. A., & Schiller, N. L. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.289 · Cited by 669
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Metadata
- Authors
- Otterlei, M., Østgaard, K., Skjåk-Bræk, G., Smidsrød, O., Soon-Shiong, P., & Espevik, T.
- Venue
- Journal of Immunotherapy
- Published
- 1991-08
- Volume
- 10
- Issue
- 4
- Pages
- 286-291
- ISSN
- 1524-9557 (ISSN-L)
- OpenAlex
- W2053148165
- Cited by
- 397
- References
- 0
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Otterlei, M., Østgaard, K., Skjåk-Bræk, G., Smidsrød, O., Soon-Shiong, P., & Espevik, T. (1991). Induction of Cytokine Production from Human Monocytes Stimulated with Alginate. Journal of Immunotherapy. https://doi.org/10.1097/00002371-199108000-00007
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