The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Effects of Intermediate- and Long-Term Use of Opioids on Cognition in Patients With Chronic Pain
Abstract
The authors review research on the intermediate- and long-term effects of taking opioid medication on cognitive functioning in patients with chronic cancer and noncancer pain. Opioids seem to be more likely to worsen cognitive performance during the first few days of use and during the first few hours after a given dose, particularly on timed performance in psychomotor tasks. Results have been inconsistent regarding what decrements in cognitive performance are observed when patients with chronic pain who have been using opioids for more than three days are compared with healthy volunteers. Relatively few differences have been found when cognitive performance in these patients is compared with their performance before taking opioids, or with the performance of a comparable pain population not taking opioids. Major unresolved questions remain regarding such important issues as effects of different types of opioids, dose effects, interactions with other medications, and subject variables.
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“However, high dose opioids are linked to a worsening of cognitive functions [61], although not in non-opioid-naïve patients [62].”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [61]
Citations
Cites
Psychoactive Drugs and the Risk of Injurious Motor Vehicle Crashes in Elderly Drivers
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Cited by
Sorted by citations
A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder.
Scott, J. C., Matt, G. E., Wrocklage, K. M., Crnich, C., Jordan, J., Southwick, S. M., Krystal, J. H., & Schweinsburg, B. C. (2015) · Psychological Bulletin · doi:10.1037/a0038039 · Cited by 513
Karp, J. F., Butters, M. A., Begley, A. E., Miller, M. D., Lenze, E. J., Blumberger, D. M., Mulsant, B. H., & Reynolds, C. F. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08725 · Cited by 191
Serafini, G., Adavastro, G., Canepa, G., De Berardis, D., Valchera, A., Pompili, M., Nasrallah, H., & Amore, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082410 · Cited by 162
Metadata
- Authors
- Chapman, S. L., Byas-Smith, M. G., & Reed, B. A.
- Affiliations
- Emory University (US)
- Corresponding author
- Chapman, Stanley L.
- Venue
- The Clinical Journal of Pain
- Published
- 2002-07
- Volume
- 18
- Issue
- Supplement
- Pages
- S83-S90
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2328048816
- Cited by
- 81
- References
- 34
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 7 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Keywords
- opioids, cognitive function, chronic pain, cognitive impairment, psychomotor performance, cancer pain, non-cancer pain, drug interactions, chronic opioid use
- MeSH terms
- Chronic Disease, Cognition, Humans, Narcotics, Neoplasms, Pain, Dextropropoxyphene, Time Factors, Meta-Analysis as Topic, Epidemiologic Studies
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