The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Effects of Intermediate- and Long-Term Use of Opioids on Cognition in Patients With Chronic Pain
Abstract
The authors review research on the intermediate- and long-term effects of taking opioid medication on cognitive functioning in patients with chronic cancer and noncancer pain. Opioids seem to be more likely to worsen cognitive performance during the first few days of use and during the first few hours after a given dose, particularly on timed performance in psychomotor tasks. Results have been inconsistent regarding what decrements in cognitive performance are observed when patients with chronic pain who have been using opioids for more than three days are compared with healthy volunteers. Relatively few differences have been found when cognitive performance in these patients is compared with their performance before taking opioids, or with the performance of a comparable pain population not taking opioids. Major unresolved questions remain regarding such important issues as effects of different types of opioids, dose effects, interactions with other medications, and subject variables.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, high dose opioids are linked to a worsening of cognitive functions [61], although not in non-opioid-naïve patients [62].”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [61]
Citations
Cites
Psychoactive Drugs and the Risk of Injurious Motor Vehicle Crashes in Elderly Drivers
Ray, W. A., Fought, R. L., & Decker, M. D. (1992) · American Journal of Epidemiology · doi:10.1093/aje/136.7.873 · Cited by 422
Randomised trial of oral morphine for chronic non-cancer pain
Moulin, D. E., Amireh, R., Sharpe, W. K. J., Boyd, D. B., Merskey, H., & Iezzi, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90339-6 · Cited by 390
The cognitive effects of the administration of narcotic analgesics in patients with cancer pain
Bruera, E. D., Macmillan, K., Hanson, J., & Macdonald, N. (1989) · Pain · doi:10.1016/0304-3959(89)90169-3 · Cited by 279
Driving ability in cancer patients receiving long-term morphine analgesia
Vainio, A., Rosenberg, P. H., Kalso, E. A., Ollila, J., & Matikainen, E. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92281-4 · Cited by 220
Dextroamphetamine with Morphine for the Treatment of Postoperative Pain
Forrest, W. H., Brown, B. W., Brown, C. R. S., et al. (1977) · New England Journal of Medicine · doi:10.1056/nejm197703312961303 · Cited by 214
A review of the effects of opioids on psychomotor and cognitive functioning in humans.
Zacny, J. P. (1995) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.3.4.432 · Cited by 186
Sjøgren, P., Thomsen, A. B., & Olsen, A. K. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(99)00143-8 · Cited by 171
Lorenz, J., Beck, H., & Bromm, B. (1997) · Pain · doi:10.1016/s0304-3959(97)00123-1 · Cited by 163
Opioid Analgesics and the Risk of Hip Fracture in the Elderly: Codeine and Propoxyphene
Shorr, R. I., Griffin, M. R., Daugherty, J. R., & Ray, W. A. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.4.m111 · Cited by 156
Use of methylphenidate as an adjuvant to narcotic analgesics in patients with advanced cancer
Bruera, E. D., Brenneis, C., Paterson, A. H. G., et al. (1989) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(89)90057-2 · Cited by 143
Stoduto, G., Vingilis, E. R., Kapur, B. M., et al. (1993) · Accident Analysis & Prevention · doi:10.1016/0001-4575(93)90070-d · Cited by 137
Effects of Opioids on Driving Ability
Galski, T., Williams, J. B. W., & Ehle, H. T. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(99)00158-x · Cited by 127
Outcome of Chronic Opioid Therapy for Non-Cancer Pain
Haythornthwaite, J. A., Menefee, L. A., Quatrano-Piacentini, A. L., & Pappagallo, M. (1998) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(97)00352-7 · Cited by 126
The cognitive and psychomotor effects of opioid analgesics
Hanks, G. W., OʼNeill, W. M., Simpson, P., et al. (1995) · European Journal of Clinical Pharmacology · doi:10.1007/bf00194334 · Cited by 100
Concentration-related effects of morphine on cognition and motor control in human subjects.
Kerr, B., Hill, H., Coda, B. A., Calogero, M., Chapman, C. R., Hunt, E. B., Buffington, V., & Mackie, A. M. (1991) · PubMed · Cited by 96
Sjøgren, P., Olsen, A. K., Thomsen, A. B., & Dalberg, J. (2000) · Pain · doi:10.1016/s0304-3959(00)00248-7 · Cited by 96
Sjøgren, P., & BANNING, A. P. (1989) · Pain · doi:10.1016/0304-3959(89)90168-1 · Cited by 89
Zacny, J. P., Lichtor, J. L., Flemming, D. C., Coalson, D. W., & Thompson, W. K. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38451-x · Cited by 86
Incidence of alcohol and drugs in fatally injured car drivers in Norway
Gjerde, H., Beylich, K. M., & Mørland, J. G. (1993) · Accident Analysis & Prevention · doi:10.1016/0001-4575(93)90078-b · Cited by 81
Subjective, psychomotor, and analgesic effects of oral codeine and morphine in healthy volunteers
Walker, D. J., & Zacny, J. P. (1998) · Psychopharmacology · doi:10.1007/s002130050757 · Cited by 74
O'Neill, M. W., Hanks, W. G., Simpson, P., Fallon, M., Jenkins, E., & Wesnes, K. A. (2000) · Pain · doi:10.1016/s0304-3959(99)00274-2 · Cited by 68
Drugs of abuse found in fatally injured drivers in Los Angeles County
Budd, R. D., Muto, J., & Wong, J. K. (1989) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(89)90021-5 · Cited by 60
Cerebral Effects of Long-Term Oral Opioids in Cancer Patients Measured by Continuous Reaction Time
BANNING, A. P., & Sjøgren, P. (1990) · Clinical Journal of Pain · doi:10.1097/00002508-199006000-00003 · Cited by 58
Alertness, cognition and morphine in patients with advanced cancer
Clemons, M. J., Regnard, C., & Appleton, T. (1996) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(96)90026-2 · Cited by 48
The Development and Initial Validation of a Sensitive Bedside Cognitive Screening Test
Faust, D., & Fogel, B. S. (1989) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198901000-00004 · Cited by 41
BANNING, A. P., Sjøgren, P., & Kaiser, F. (1992) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1992.tb03501.x · Cited by 41
Drug findings in ‘driving under the influence of drugs’ cases: A problem of illicit drug use
Poklis, A., Maginn, D., & Barr, J. L. (1987) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(87)90076-7 · Cited by 39
Neuropsychological and Pharmacokinetic Assessment of Hospice Inpatients Receiving Morphine
Wood, M. M., Ashby, M. A., Somogyi, A. A., & Fleming, B. G. (1998) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(98)00043-8 · Cited by 32
The cognitive and psychomotor effects of opioid drugs in cancer pain management.
OʼNeill, W. M. (1994) · PubMed · Cited by 28
Some effects of morphine and amphetamine on intellectual functions and mood
Evans, W. Ο., & Smith, R. P. (1964) · Psychopharmacology · doi:10.1007/bf00710914 · Cited by 28
Saarialho‐Kere, U., Julkunen, H. A., Mattila, M. J., et al. (1988) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1988.tb00956.x · Cited by 27
Wikler, A., Haertzen, C. A., Chessick, R. D., et al. (1965) · Psychopharmacology · doi:10.1007/bf00402365 · Cited by 19
Codeine-induced memory changes: Nature and relationship to opiate system
Liljequist, R. (1981) · European Journal of Clinical Pharmacology · doi:10.1007/bf00607144 · Cited by 19
Medication-Induced Performance Deficits: Analgesics and Narcotics
Payne, R. (1990) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199004000-00018 · Cited by 12
Research works printed but not linked: 6
- Turk, 1992, APS Bull, 2, 1
- O'Neill, 1994, Cancer Surv, 21, 67
- Kerr, 1991, Neuropsychopharmacol, 5, 157
- Zacny, 1994, J Pharmacol Exp Ther, 268, 1
- Zacny JP Lichtor, 1994, J Pharmacol Exp Ther, 270, 579
- Twycross, 1979, Adv Pain Res Ther, 2, 291
Cited by
Sorted by citations
A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder.
Scott, J. C., Matt, G. E., Wrocklage, K. M., Crnich, C., Jordan, J., Southwick, S. M., Krystal, J. H., & Schweinsburg, B. C. (2015) · Psychological Bulletin · doi:10.1037/a0038039 · Cited by 513
Karp, J. F., Butters, M. A., Begley, A. E., Miller, M. D., Lenze, E. J., Blumberger, D. M., Mulsant, B. H., & Reynolds, C. F. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08725 · Cited by 191
Serafini, G., Adavastro, G., Canepa, G., De Berardis, D., Valchera, A., Pompili, M., Nasrallah, H., & Amore, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082410 · Cited by 162
Metadata
- Authors
- Chapman, S. L., Byas-Smith, M. G., & Reed, B. A.
- Affiliations
- Emory University (US)
- Corresponding author
- Chapman, Stanley L.
- Venue
- The Clinical Journal of Pain
- Published
- 2002-07
- Volume
- 18
- Issue
- Supplement
- Pages
- S83-S90
- ISSN
- 0749-8047 (ISSN-L)
- OpenAlex
- W2328048816
- Cited by
- 81
- References
- 34
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 7 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Keywords
- opioids, cognitive function, chronic pain, cognitive impairment, psychomotor performance, cancer pain, non-cancer pain, drug interactions, chronic opioid use
- MeSH terms
- Chronic Disease, Cognition, Humans, Narcotics, Neoplasms, Pain, Dextropropoxyphene, Time Factors, Meta-Analysis as Topic, Epidemiologic Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
