The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Clinical Evaluation of Recombinant Human Bone Morphogenetic Protein-2
Abstract
Recombinant human bone morphogenetic protein-2 is an osteoinductive protein that plays a pivotal role in bone growth and regeneration. Several hundred studies were conducted in the past 7 years in numerous animal models to establish unequivocally the efficacy, safety, mechanism of action, pharmacokinetics, and surgical handling properties of recombinant human bone morphogenetic protein-2, building a solid foundation for clinical development programs. Pilot clinical trials have shown the feasibility and safety of recombinant human bone morphogenetic protein-2 treatment, and defined the effective dose for its use in open long bone fractures and for augmentation or preservation of the alveolar bone in the dental ridge. Prospective observational clinical studies helped define clinical efficacy end points, identify significant variables, and estimate appropriate population sample size for pivotal clinical trials. Pivotal clinical trials of recombinant human bone morphogenetic protein-2 are underway in patients with open tibial shaft fractures and in patients with a deficiency of the alveolar ridge.
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Cites
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Recombinant human bone morphogenetic protein induces bone formation.
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Bone Morphogenetic Protein and Bone Morphogenetic Protein Gene Family in Bone Formation and Repair
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Self-citationBoyne, P. J., Marx, R. E., Nevins, M., Triplett, G. R., Lazaro, E., Lilly, L. C., Alder, M. E., & Nummikoski, P. V. (1997) · PubMed · Cited by 439
Self-citationImmunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing
Bostrom, M. P. G., Lane, J. M., Berberian, W. S., Missri, A. A. E., Tomin, E., Weiland, A., Doty, S. B., Glaser, D., & Rosen, V. M. (1995) · Journal of Orthopaedic Research · doi:10.1002/jor.1100130309 · Cited by 373
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Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration
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Self-citation
Cited by
Carano, R. A. D., & Filvaroff, E. H. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02866-6 · Cited by 746
Endogenous TGF‐β signaling suppresses maturation of osteoblastic mesenchymal cells
Maeda, S., Hayashi, M., Komiya, S., Imamura, T., & Miyazono, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600067 · Cited by 339
Electrospun polymer micro/nanofibers as pharmaceutical repositories for healthcare
Feng, X., Li, J., Zhang, X., Liu, T., Ding, J., & Chen, X. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.020 · Cited by 322
Bone tissue engineering by gene delivery
KOFRON, M., & LAURENCIN, C. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.008 · Cited by 151
Megakaryocytes modulate osteoblast synthesis of type-l collagen, osteoprotegerin, and RANKL
BORD, S., FRITH, E., IRELAND, D., SCOTT, M., CRAIG, J., & COMPSTON, J. (2005) · Bone · doi:10.1016/j.bone.2004.12.006 · Cited by 63
Metadata
- Authors
- Valentin-Opran, A., Wozney, J., Csimma, C., Lilly, L., & Riedel, G. E.
- Venue
- Clinical Orthopaedics and Related Research
- Published
- 2002-02
- Volume
- 395
- Issue
- 395
- Pages
- 110-120
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W2015653841
- Cited by
- 288
- References
- 23
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Valentin-Opran, A., Wozney, J., Csimma, C., Lilly, L., & Riedel, G. E. (2002). Clinical Evaluation of Recombinant Human Bone Morphogenetic Protein-2. Clinical Orthopaedics and Related Research. https://doi.org/10.1097/00003086-200202000-00011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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