Cited by 201Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional DevelopmentChild Therapy and Development

Imipramine Treatment of Children with Separation Anxiety Disorder

KLEIN, RACHEL G., KOPLEWICZ, HAROLD S., KANNER, ANDRES·1992·Journal of the American Academy of Child & Adolescent Psychiatry

Abstract

The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population.

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Registry

Crossref · 10.1097/00004583-199201000-00005

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29 of 29 references verified0 citation errors · 0 not checkable

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  • Later studies extended antidepressant treatment to pediatric anxiety disorders.

    “Later studies extended antidepressant treatment to pediatric anxiety disorders (21,22).”

    From Pediatric psychopharmacology: Too much or too little? (2013) · cites this paper as [21]

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Authors
KLEIN, R. G., KOPLEWICZ, H. S., & KANNER, A.
Affiliations
  • Columbia University (US)
  • New York State Psychiatric Institute (US)
Corresponding author
KLEIN, RACHEL G.
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
1992-01
Volume
31
Issue
1
Pages
21-28
ISSN
0890-8567 (ISSN-L)
OpenAlex
W1972768281
Cited by
201
References
29
Citations by year
2024: 1 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 6
FWCI
15.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh037001-03)
  • National Institute of Mental Health (MH16434, T32MH016434, MH-37001, MH30906)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Child Therapy and Development
Keywords
imipramine, separation anxiety disorder, children, tricyclic antidepressants, behavior therapy, treatment efficacy, electrocardiographic changes
MeSH terms
Adolescent, Anxiety, Separation, Child, Combined Modality Therapy, Desensitization, Psychologic, Double-Blind Method, Female, Humans, Imipramine, Male, Psychotherapy, Brief

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