Imipramine Treatment of Children with Separation Anxiety Disorder
Abstract
The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population.
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Later studies extended antidepressant treatment to pediatric anxiety disorders.
“Later studies extended antidepressant treatment to pediatric anxiety disorders (21,22).”
From Pediatric psychopharmacology: Too much or too little? (2013) · cites this paper as [21]
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- Authors
- KLEIN, R. G., KOPLEWICZ, H. S., & KANNER, A.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- KLEIN, RACHEL G.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 31
- Issue
- 1
- Pages
- 21-28
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W1972768281
- Cited by
- 201
- References
- 29
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 6
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh037001-03)
- National Institute of Mental Health (MH16434, T32MH016434, MH-37001, MH30906)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Child Therapy and Development
- Keywords
- imipramine, separation anxiety disorder, children, tricyclic antidepressants, behavior therapy, treatment efficacy, electrocardiographic changes
- MeSH terms
- Adolescent, Anxiety, Separation, Child, Combined Modality Therapy, Desensitization, Psychologic, Double-Blind Method, Female, Humans, Imipramine, Male, Psychotherapy, Brief
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