Cited by 118Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorBipolar Disorder and Treatment

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Quantification of Neuroreceptors in the Living Human Brain: IV. Effect of Aging and Elevations of D 2 -Like Receptors in Schizophrenia and Bipolar Illness

Wong, Dean F., Pearlson, Godfrey D., Tune, Larry E., Young, L. Trevor, Meltzer, Carolyn Cidis, Dannals, Robert F., Ravert, Hayden T., Reith, Jakob, Kuhar, Michael J., Gjedde, Albert·1997·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1097/00004647-199703000-00010

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Abstract

In a previous study of 10 drug-naive schizophrenic patients, the density of D 2 dopamine receptors was found to be elevated in the caudate nucleus. The study raised questions about the influence of the age of the patients, the relationship of receptor density to psychosis, and the accuracy of the method used to obtain this evidence. Using positron emission tomography and constrained analysis of the brain uptake of the radioligand N-[ 11 C] methylspiperone ([ 11 C]NMSP), we tested four questions: Were the assumptions underlying the quantitation valid? Is there an age decline of the density of D 2 -like dopamine receptors in drug-naive schizophrenia and bipolar illness? If so, is it different from that observed in normal aging? Are D 2 -like dopamine receptors elevated at any age in either drug-naive schizophrenic or psychotic bipolar illness patients? NMSP and haloperidol partition volumes and plasma protein fractions were not significantly different among patient groups and normal volunteers. The model-derived assay of radioligand metabolites in plasma was confirmed by high-performance liquid chromatography in the patient groups. D 2 -like dopamine receptors declined with age, and the slope did not differ significantly between the schizophrenic patients, bipolar affective illness patients, and normal controls. Taking the effect of age into account, increases in D 2 dopamine receptor density were found in seven psychotic patients with bipolar affective illness compared with seven nonpsychotic patients and 24 control subjects as well as in 22 drug-naive schizophrenic patients compared with the 24 control subjects.

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Authors: Wong, D. F., Pearlson, G. D., Tune, L. E., Young, L. T., Meltzer, C. C., Dannals, R. F., Ravert, H. T., Reith, J., Kuhar, M. J., & Gjedde, A.
Affiliations: Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Baltimore, Maryland
Department of Psychiatry, Neuroscience Branch, Baltimore, Maryland
Bispebjerg Hospital (DK)
National Institute on Drug Abuse (US)
Aarhus University Hospital (DK)
Corresponding author: Wong, Dean F.
ORCID: Wong, Dean F.
Pearlson, Godfrey D.
Young, L. Trevor
Meltzer, Carolyn Cidis
Dannals, Robert F.
Ravert, Hayden T.
Gjedde, Albert
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 1997-03
Volume: 17
Issue: 3
Pages: 331-342
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1097/00004647-199703000-00010
OpenAlex: W2036684254
Cited by: 118
References: 40
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 8
FWCI: 3.72
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh042821-07, 5r01mh040362-07)
Centers for Disease Control and Prevention (KO1 MN00723)
National Institute of Mental Health (R01 MH40362, R01MH42821)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords: dopamine D2 receptor, D2-like receptors, schizophrenia, aging, receptor density, caudate nucleus, positron emission tomography, receptor quantification, drug-naive patients, psychosis
MeSH terms: Adult, Aged, Aging, Basal Ganglia, Bipolar Disorder, Brain Chemistry, Caudate Nucleus, Chromatography, High Pressure Liquid, Female, Humans, Male, Middle Aged, Nerve Tissue Proteins, Schizophrenia, Spiperone, Tomography, Emission-Computed, Receptors, Dopamine D2, Dopamine Agonists

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Quantification of Neuroreceptors in the Living Human Brain: IV. Effect of Aging and Elevations of D 2 -Like Receptors in Schizophrenia and Bipolar Illness

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