The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Evidence for Apoptosis After Intracerebral Hemorrhage in Rat Striatum
Abstract
The overall hypothesis that cell death after intracerebral hemorrhage is mediated in part by apoptotic mechanisms was tested. Intracerebral hemorrhage was induced in rats using stereotactic infusions of 0.5 U of collagenase (1-μL volume) into the striatum. After 24 hours, large numbers of TUNEL-positive stained cells with morphologies suggestive of apoptosis were present in the center and periphery of the hemorrhage. Double staining with Nissl and immunocytochemical labeling with antibodies against neuronal nuclei and glial fibrillary acidic protein suggested that these TUNEL-positive cells were mostly neurons and astrocytes. Electrophoresis of hemorrhagic brain extracts showed evidence of DNA laddering into ∼200-bp fragments. Western blots showed cleavage of the cytosolic caspase substrate gelsolin. The density of TUNEL-positive cells at 24 and 48 hours after hemorrhage was significantly reduced by treatment with the broad-spectrum caspase inhibitor zVADfmk. It was unlikely that apoptotic changes were due to neurotoxicity of injected collagenase because TUNEL-positive cells and DNA laddering were also obtained in an alternative model of hemorrhage where autologous blood was infused into the striatum. Furthermore, equivalent doses of collagenase did not induce cell death in primary neuronal cultures. These results provide initial evidence that apoptotic mechanisms may mediate some of the injury in brain after intracerebral hemorrhage.
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Cited by
Mechanisms of brain injury after intracerebral haemorrhage
Xi, G., Keep, R. F., & Hoff, J. T. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70283-0 · Cited by 1,360
Free Radical Pathways in CNS Injury
LEWÉN, A., MATZ, P., & CHAN, P. H. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.871 · Cited by 759
Mechanisms of Early Brain Injury after Subarachnoid Hemorrhage
Cahill, W. J., Calvert, J. H., & Zhang, J. H. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600283 · Cited by 630
Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
Lee, S.-T., Chu, K., Jung, K.-H., Kim, S.-J., Kim, D.-H., Kang, K.-M., Hong, N. H., Kim, J.-H., Ban, J.-J., Park, H.-K., et al. (2008) · Brain · doi:10.1093/brain/awm306 · Cited by 424
Intracerebral Hemorrhage Models in Rat: Comparing Collagenase to Blood Infusion
MacLellan, C. L., Silasi, G., Poon, C. C., Edmundson, C. L., Buist, R., Peeling, J., & Colbourne, F. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600548 · Cited by 339
Metadata
- Authors
- Matsushita, K., Meng, W., Wang, X., Asahi, M., Asahi, K., Moskowitz, M. A., & Lo, E. H.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2000-02
- Volume
- 20
- Issue
- 2
- Pages
- 396-404
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2028531319
- Cited by
- 254
- References
- 59
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Matsushita, K., Meng, W., Wang, X., Asahi, M., Asahi, K., Moskowitz, M. A., & Lo, E. H. (2000). Evidence for Apoptosis After Intracerebral Hemorrhage in Rat Striatum. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1097/00004647-200002000-00022
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