The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Functional Differentiation of Multiple Perilesional Zones after Focal Cerebral Ischemia
Open accessAbstract
Transient and permanent focal cerebral ischemia results in a series of typical pathophysiologic events. These consequences evolve in time and space and are not limited to the lesion itself, but they can be observed in perilesional (penumbra) and widespread ipsi- and sometimes contralateral remote areas (diaschisis). The extent of these areas is variable depending on factors such as the type of ischemia, the model, and the functional modality investigated. This review describes some typical alterations attributable to focal cerebral ischemia using the following classification scheme to separate different lesioned and perilesional areas: (1) The lesion core is the brain area with irreversible ischemic damage. (2) The penumbra is a brain region that suffers from ischemia, but in which the ischemic damage is potentially, or at least partially, reversible. (3) Remote brain areas are brain areas that are not directly affected by ischemia. With respect to the etiology, several broad categories of remote changes may be differentiated: (3a) remote changes caused by brain edema; (3b) remote changes caused by waves of spreading depression; (3c) remote changes in projection areas; and (3d) remote changes because of reactive plasticity and systemic effects. The various perilesional areas are not necessarily homogeneous; but a broad differentiation of separate topographic perilesional areas according to their functional state and sequelae allows segregation into several signaling cascades, and may help to understand the functional consequences and adaptive processes after focal brain ischemia.
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Cites
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“In addition, a rapid contralateral activation of NOS-I and a longer lasting up-regulation of APP and neurofilament 68 have been found in rodents (Pierce et al., 1996), whereas in humans a transient contralateral phosphorylation of neurofilament H occurs (Hedreen et al.”
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Self-citation
Cited by
A Neurovascular Niche for Neurogenesis after Stroke
Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878
Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21393 · Cited by 875
Plasticity of Cortical Projections after Stroke
Carmichael, S. T. (2003) · The Neuroscientist · doi:10.1177/1073858402239592 · Cited by 378
Anatomy and Functionality of Leptomeningeal Anastomoses: A Review
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Hobohm, C., Günther, A., Grosche, J., Roßner, S., Schneider, D., & Brückner, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20459 · Cited by 103
Enright, L. E., Zhang, S., & Murphy, T. H. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600428 · Cited by 74
Tissue Microenvironments within Functional Cortical Subdivisions Adjacent to Focal Stroke
Katsman, D., Zheng, J., Spinelli, K., & Carmichael, S. T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000084252.20114.be · Cited by 52
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Pielecka-Fortuna, J., Kalogeraki, E., Fortuna, M. G., & Löwel, S. (2015) · eLife · doi:10.7554/elife.11290 · Cited by 21
Chiu, Y.-S., Wu, K.-J., Yu, S.-J., Wu, K.-L., Hsieh, C.-Y., Chou, Y.-S., Chen, K.-Y., Wang, Y.-S., Bae, E.-K., Hung, T.-W., et al. (2024) · Cell Transplantation · doi:10.1177/09636897241296366 · Cited by 10
Kleim (n.d.) · doi:10.1044/1092-4388(2008/018
Metadata
- Authors
- Witte, O. W., Bidmon, H.-J., Schiene, K., Redecker, C., & Hagemann, G.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2000-08
- Volume
- 20
- Issue
- 8
- Pages
- 1149-1165
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2063590057
- Cited by
- 252
- References
- 6
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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