Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
Open accessAbstract
The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur.
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In Mmp9−/− mice, there is no increase in the strength of the non-deprived input following monocular deprivation.
“However, we did not observe an increase in the strength of the non-deprived input in Mmp9−/− mice, consistent with previous reports (Spolidoro et al., 2012; Kelly et al., 2015; Pielecka-Fortuna et al., 2015)”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Pielecka-Fortuna et al., 2015
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- Authors
- Pielecka-Fortuna, J., Kalogeraki, E., Fortuna, M. G., & Löwel, S.
- Affiliations
- University of Göttingen (DE)
- German Primate Center (DE)
- Corresponding author
- Pielecka-Fortuna, Justyna
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-11-26
- Volume
- 4
- Pages
- e11290-e11290
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC4718812
- OpenAlex
- W2177999697
- Cited by
- 21
- References
- 70
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 2 · 2017: 3 · 2016: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- GRO (submittedVersion, cc-by)
- Funders
- Alexander von Humboldt-Stiftung (Alexander von Humboldt-Foundation)
- Bundesministerium für Bildung und Forschung (01GQ0921, 01GQ0810)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- matrix metalloproteinases, matrix metalloproteinase inhibition, primary visual cortex, stroke, experience-dependent plasticity, brain injury recovery, lesion spread
- MeSH terms
- Animals, Disease Models, Animal, Neuronal Plasticity, Visual Cortex, Visual Perception, Stroke, Matrix Metalloproteinases, Mice
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