The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Programmed Cell Death in Cerebral Ischemia
Open accessAbstract
Programmed cell death (PCD) is an ordered and tightly controlled set of changes in gene expression and protein activity that results in neuronal cell death during brain development. This article reviews the molecular pathways by which PCD is executed in mammalian cells and the potential relation of these pathways to pathologic neuronal cell death. Whereas the classical patterns of apoptotic morphologic change often do not appear in the brain after ischemia, there is emerging biochemical and pharmacologic evidence suggesting a role for PCD in ischemic brain injury. The most convincing evidence for the induction of PCD after ischemia includes the altered expression and activity in the ischemic brain of deduced key death-regulatory genes. Furthermore, studies have shown that alterations in the activity of these gene products by peptide inhibitors, viral vector-mediated gene transfer, antisense oligonucleotides, or transgenic mouse techniques determine, at least in part, whether ischemic neurons live or die after stroke. These studies provide strong support for the hypothesis that PCD contributes to neuronal cell death caused by ischemic injury. However, many questions remain regarding the precise pathways that initiate, sense, and transmit cell death signals in ischemic neurons and the molecular mechanisms by which neuronal cell death is executed at different stages of ischemic injury. Elucidation of these pathways and mechanisms may lead to the development of novel therapeutic strategies for brain injury after stroke and related neurologic disorders.
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Cites
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Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
Arundine, M., & Tymianski, M. (2004) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-3319-x · Cited by 647
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Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons
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Exciting, Radical, Suicidal: How Brain Cells Die After Stroke
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Neuroprotective Effect of Human Placenta-Derived Cell Treatment of Stroke in Rats
Chen, J., Shehadah, A., Pal, A., Zacharek, A., Cui, X., Cui, Y., Roberts, C., Lu, M., Zeitlin, A., Hariri, R., et al. (2013) · Cell Transplantation · doi:10.3727/096368911x637380 · Cited by 70
Self-citationRyanodine receptor inhibitor dantrolene reduces hypoxic-ischemic brain injury in neonatal mice
Ovcjak, A., Xiao, A., Kim, J.-S., Xu, B., Szeto, V., Turlova, E., Abussaud, A., Chen, N.-H., Miller, S. P., Sun, H.-S., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.113985 · Cited by 16
YIN, C.-P., GUAN, S.-H., ZHANG, B., WANG, X.-X., & YUE, S.-W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4267 · Cited by 9
Metadata
- Authors
- Graham, S. H., & Chen, J.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2001-02
- Volume
- 21
- Issue
- 2
- Pages
- 99-109
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2072847038
- Cited by
- 472
- References
- 3
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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