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Cited by 96Effects of Radiation ExposureCell death mechanisms and regulationNeurological Disorders and Treatments

Tetracycline derivatives and ceftriaxone, a cephalosporin antibiotic, protect neurons against apoptosis induced by ionizing radiation

Tikka, Tiina, Usenius, Taina, Tenhunen, Mikko, Keinänen, Riitta, Koistinaho, Jari·2001·Journal of Neurochemistry
DOI 10.1046/j.1471-4159.2001.00543.x
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Abstract

DNA damage induced by low doses of ionizing radiation causes apoptosis, which is partially mediated via the generation of free radicals. Both free radicals and apoptosis are involved in the majority of brain diseases, including stroke, Alzheimer's disease and amyotrophic lateral sclerosis. Because previous studies have shown that tetracycline derivatives doxycycline and minocycline have anti‐inflammatory effects and are protective against brain ischemia, we studied whether minocycline and doxycycline or ceftriaxone, a cephalosporin antibiotic with the potential to inhibit excitotoxicity, protect neurons against ionizing radiation in primary cortical cultures. A single dose of 1 Gy significantly increased lactate dehydrogenase release, induced DNA fragmentation in neurons and triggered microglial proliferation. Treatment with minocycline (20 n m), doxycycline (20 n m) and ceftriaxone (1 µ m) significantly reduced irradiation‐induced lactate dehydrogenase release and DNA fragmentation. The most efficient protection was achieved by minocycline treatment, which also inhibited the irradiation‐induced increase in microglial cell number. Our results suggest that some tetracycline derivatives, such as doxycycline and minocycline, and ceftriaxone, a cephalosporin derivative, protect neurons against apoptotic death.

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Authors
Tikka, T., Usenius, T., Tenhunen, M., Keinänen, R., & Koistinaho, J.
Affiliations
  • University of Eastern Finland (FI)
  • Helsinki University Hospital (FI)
ORCID
Tenhunen, Mikko
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2001-09-15
Volume
78
Issue
6
Pages
1409-1414
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1046/j.1471-4159.2001.00543.x
OpenAlex
W2104886236
Cited by
96
References
35
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 9 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 96 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords
tetracycline derivatives, minocycline, doxycycline, ceftriaxone, ionizing radiation, radiation-induced apoptosis, neuroprotection, DNA fragmentation, microglial proliferation, free radicals, cortical neurons
MeSH terms
Animals, Anti-Bacterial Agents, Ceftriaxone, Cells, Cultured, Cephalosporins, Doxycycline, Minocycline, Neurons, Radiation Injuries, Rats, Wistar, Apoptosis, Neuroprotective Agents, Rats

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