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Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values
Abstract
A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man non-invasively, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.
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Citations
Cited by
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Conceptual Processing during the Conscious Resting State: A Functional MRI Study
Binder, J. R., Frost, J. A., Hammeke, T. A., Bellgowan, P. S. F., Rao, S. M., & Cox, R. W. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563265 · Cited by 1,066
Behind the scenes of functional brain imaging: A historical and physiological perspective
Raichle, M. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.765 · Cited by 616
Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J. (1993) · Psychological Medicine · doi:10.1017/s0033291700025368 · Cited by 530
Self-citationThe capillary network: A link between IVIM and classical perfusion
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Metadata
- Authors
- Frackowiak, R. S. J., Lenzi, G.-L., Jones, T., & Heather, J. D.
- Venue
- Journal of Computer Assisted Tomography
- Published
- 1980-12
- Volume
- 4
- Issue
- 6
- Pages
- 727-736
- ISSN
- 0363-8715 (ISSN-L)
- OpenAlex
- W2050112450
- Cited by
- 1,242
- References
- 0
- FWCI
- 27.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values. https://app.cochat.ai/papers/10.1097/00004728-198012000-00001
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- Frackowiak, R. S. J., Lenzi, G.-L., Jones, T., & Heather, J. D. (1980). Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values. Journal of Computer Assisted Tomography. https://doi.org/10.1097/00004728-198012000-00001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
