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Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values
Abstract
A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man non-invasively, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.
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Binder, J. R., Frost, J. A., Hammeke, T. A., Bellgowan, P. S. F., Rao, S. M., & Cox, R. W. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563265 · Cited by 1,066
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Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J. (1993) · Psychological Medicine · doi:10.1017/s0033291700025368 · Cited by 530
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Martin, A. J., Friston, K. J., Colebatch, J. G., & Frackowiak, R. S. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.121 · Cited by 393
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Bench, C. J., Frackowiak, R. S. J., & Dolan, R. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700036151 · Cited by 351
Self-citationRegional cerebral blood flow and oxygen consumption in human aging
Pantano, P., Baron, J. C., Lebrun-Grandié, P., Duquesnoy, N., Bousser, M. G., & Comar, D. (1984) · Stroke · doi:10.1161/01.str.15.4.635 · Cited by 341
Kuhl, D. E., Metter, E. J., Riege, W. H., & Phelps, M. E. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.15 · Cited by 338
Functional plasticity in cognitive aging: Review and hypothesis.
Greenwood, P. M. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.6.657 · Cited by 304
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Ring, H. A., Bench, C. J., Trimble, M. R., Brooks, D. J., Frackowiak, R. S. J., & Dolan, R. J. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.165.3.333 · Cited by 219
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Bentourkia, M., Bol, A., Ivanoiu, A., Labar, D., Sibomana, M., Coppens, A., Michel, C., Cosnard, G., & De Volder, A. G. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00396-8 · Cited by 189
Versijpt, J., Debruyne, J. C., Van Laere, K. J., De Vos, F., Keppens, J., Strijckmans, K., Achten, E., Slegers, G., Dierckx, R. A., Korf, J., et al. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1140oa · Cited by 126
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Haxby, J. V., Grady, C. L., Ungerleider, L. G., & Horwitz, B. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90009-w · Cited by 104
Wenz, F., Rempp, K., Brix, G., Knopp, M. V., Gückel, F., Heß, T., & van Kaick, G. (1996) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(95)02058-2 · Cited by 57
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Metadata
- Authors
- Frackowiak, R. S. J., Lenzi, G.-L., Jones, T., & Heather, J. D.
- Venue
- Journal of Computer Assisted Tomography
- Published
- 1980-12
- Volume
- 4
- Issue
- 6
- Pages
- 727-736
- ISSN
- 0363-8715 (ISSN-L)
- OpenAlex
- W2050112450
- Cited by
- 1,242
- References
- 0
- FWCI
- 27.57
- Type
- journal article
- Language
- en
- Open access
- closed
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