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Cited by 117Hormonal and reproductive studiesBlood Coagulation and Thrombosis MechanismsBlood properties and coagulation

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Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension

Phillips, Gerald B., Jing, Tian-Yi, Resnick, Lawrence M., Barbagallo, Mario, Laragh, John H., Sealey, Jean E.·1993·Journal of Hypertension
DOI 10.1097/00004872-199307000-00003
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Abstract

OBJECTIVE AND DESIGN: It has been hypothesized that risk factors for coronary heart disease in men are linked and that the underlying factor linking them may be an alteration in the sex hormone milieu. As a test of this hypothesis, sex hormones and fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), hemostatic factors recently shown to be risk factors for myocardial infarction, were measured in men with hypertension and in healthy control subjects. RESULTS: The fasting serum testosterone and free testosterone levels were decreased and the plasma factor VII and PAI-1 levels increased in the men with hypertension. CONCLUSION: These findings are consistent with the stated hypothesis.

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Crossref · 10.1097/00004872-199307000-00003

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Metadata

Authors
Phillips, G. B., Jing, T.-Y., Resnick, L. M., Barbagallo, M., Laragh, J. H., & Sealey, J. E.
Affiliations
St. Luke's-Roosevelt Hospital Center (US)
ORCID
Barbagallo, Mario
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1993-07
Volume
11
Issue
7
Pages
699-702
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/00004872-199307000-00003
OpenAlex
W2082141756
Cited by
117
References
0
Citations by year
2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 6
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (621419)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords
sex hormones, testosterone, free testosterone, coronary artery disease, hypertension, hemostasis, fibrinogen, factor VII, plasminogen activator inhibitor-1, myocardial infarction risk, men
MeSH terms
Blood Coagulation Factors, Coronary Disease, Humans, Hypertension, Male, Middle Aged, Risk Factors, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone

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