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Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension
Abstract
OBJECTIVE AND DESIGN: It has been hypothesized that risk factors for coronary heart disease in men are linked and that the underlying factor linking them may be an alteration in the sex hormone milieu. As a test of this hypothesis, sex hormones and fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), hemostatic factors recently shown to be risk factors for myocardial infarction, were measured in men with hypertension and in healthy control subjects. RESULTS: The fasting serum testosterone and free testosterone levels were decreased and the plasma factor VII and PAI-1 levels increased in the men with hypertension. CONCLUSION: These findings are consistent with the stated hypothesis.
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“Serum testosterone levels have been reported to be lower in men with hypertension (40).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [40]
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Testosterone levels in men with type 2 diabetes mellitus
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“Low testosterone levels have been observed in association with dyslipidemia and hypertension.(20) Although the focus of this study was to determine testosterone levels in men with Type 2 diabetes mellitus, there are findings of lower testosterone levels in cigarette smokers (Table 7,8) in our study.”
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Androgens and Coronary Artery Disease
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“Several studies examining hypertensive men demonstrated a significant inverse relationship between blood pressure and total serum testosterone, which could be associated with impaired reproductive potential [29-31], free testosterone [32-34] and SHBG [34].”
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The future of hypertension pharmacotherapy: Ongoing and future clinical trials for hypertension
Mansoor, T., Farrukh, F., Khalid, S. N., Abramov, D., Michos, E. D., Mehta, A., Paul, T. K., Dani, S. S., Rifai, M. A., Misra, A., et al. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102922 · Cited by 2
Perusquı́a, M., & Herrera, N. (2024) · Pharmacology · doi:10.1159/000542007 · Cited by 3
Masked hypertension unfavourably affects haemostasis parameters
Papadopoulos, D., Thomopoulos, C., Mourouzis, I. S., Kotrotsou, A., Sanidas, E. A., Papazachou, U. G., Daskalaki, M., & Makris, T. (2011) · Blood Pressure · doi:10.3109/08037051.2011.565551 · Cited by 2
Premature coronary artery disease and testosterone in Sri Lankan men
Wickramatilake, C., Mohideen, M., & Pathirana, C. (2014) · Sri Lanka Journal of Diabetes Endocrinology and Metabolism · doi:10.4038/sjdem.v4i1.7242 · Cited by 2
“There are studies indicating that a low testosterone level is related to the risk factors of cardiovascular disease as well (8, 9, 10).”
BackgroundHwang, H., Kim, Y. S., Sunwoo, S., Yu, B.-Y., Bae, W.-K., Park, J. S., Park, Y., Park, Y.-K., Yang, Y. J., Kim, C.-M., et al. (2013) · Journal of Men s Health · doi:10.1089/jomh.2013.1505 · Cited by 1
“24,25 This is because of the difference in the severity of the diseases among study populations.”
Metadata
- Authors
- Phillips, G. B., Jing, T.-Y., Resnick, L. M., Barbagallo, M., Laragh, J. H., & Sealey, J. E.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- ORCID
- Barbagallo, Mario
- Venue
- Journal of Hypertension
- Published
- 1993-07
- Volume
- 11
- Issue
- 7
- Pages
- 699-702
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2082141756
- Cited by
- 117
- References
- 0
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 6
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (621419)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Keywords
- sex hormones, testosterone, free testosterone, coronary artery disease, hypertension, hemostasis, fibrinogen, factor VII, plasminogen activator inhibitor-1, myocardial infarction risk, men
- MeSH terms
- Blood Coagulation Factors, Coronary Disease, Humans, Hypertension, Male, Middle Aged, Risk Factors, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone
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