The DOI matches its Crossref record.
Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin
Abstract
OBJECTIVE: To determine the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene in several ethnic groups: Caucasian Europeans, Black Nigerians, Samoan Polynesians and Yanomami Indians. RESULTS: The ratio of the frequencies of the II, ID and DD genotypes were 1:2:1 in the Europeans, but there was a tendency towards a higher frequency of the D allele in the Nigerians. In contrast, the Samoans and the Yanomami Indians displayed a much higher frequency of the I allele than of the D allele. CONCLUSION: The relationship between ACE genotype and disease in these latter groups is still not known, but the present results clearly suggest that ethnic origin should be carefully considered in the increasing number of studies on the association between I/D ACE genotype and disease aetiology.
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Cited by
Human angiotensin I-converting enzyme gene and endurance performance
Myerson, S., Hemingway, H., Budget, R., Martin, J., Humphries, S., Montgomery, H., & McGloin), (. T. T. A. O. M. M. A. H. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.4.1313 · Cited by 398
Staessen, J. A., Wang, J. G., Ginocchio, G., Petrov, V., Saavedra, A. P., Soubrier, F., Vlietinck, R., & Fagard, R. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715120-00059 · Cited by 385
Angiotensin-converting enzyme inhibitor fetopathy.
Pryde, P. G., Sedman, A. B., Nugent, C. E., & Barr, M. (1993) · Journal of the American Society of Nephrology · doi:10.1681/asn.v391575 · Cited by 332
Composite estimates of physiological stress, age, and diabetes in American Samoans
Crews, D. E. (2007) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20612 · Cited by 32
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Metadata
- Authors
- Barley, J., Blackwood, A., Carter, N. D., Crews, D. E., Cruickshank, J. K., Jeffery, S., Ogunlesi, A. O., & Sagnella, G. A.
- Venue
- Journal of Hypertension
- Published
- 1994-08
- Volume
- 12
- Issue
- 8
- Pages
- 995
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W1987328145
- Cited by
- 176
- References
- 0
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barley, J., Blackwood, A., Carter, N. D., Crews, D. E., Cruickshank, J. K., Jeffery, S., Ogunlesi, A. O., & Sagnella, G. A. (1994). Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin. Journal of Hypertension. https://doi.org/10.1097/00004872-199408000-00014
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