The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Human angiotensin I-converting enzyme gene and endurance performance
Abstract
Human physical performance is strongly influenced by genetic factors. A variation in the structure of the human angiotensin I-converting enzyme (ACE) gene has been reported in which the insertion (I) variant is associated with lower ACE levels than the deletion (D) gene. We have previously reported that the I variant was associated with improved endurance performance in high-altitude mountaineers and British Army recruits. We now examine this genotype distribution in 91 British Olympic-standard runners (79 Caucasians). DNA was extracted from the buccal cells contained in 10 ml of saline mouthwash donated by the subjects, and the I and D variants of the ACE gene were identified by PCR amplification of the polymorphic region. There was an increasing frequency of the I allele with distance run [0.35, 0.53, and 0.62 for ≤200 m ( n = 20), 400–3,000 m ( n = 37), and ≥5,000 m ( n = 34), respectively; P = 0.009 for linear trend]. Among 404 Olympic-standard athletes from 19 other mixed sporting disciplines (in which endurance performance was not necessarily a key factor), the I allele did not differ significantly from that found in control subjects: 0.50 vs. 0.49 ( P = 0.526). These results support a positive association of the I allele with elite endurance performance.
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Angiotensin-Converting Enzyme in the Human Heart: Effect of the Deletion/Insertion Polymorphism
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Human gene for physical performance
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Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin
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Cited by
ACTN3 Genotype Is Associated with Human Elite Athletic Performance
Yang, N., MacArthur, D. G., Gulbin, J. P., Hahn, A. G., Beggs, A. H., Easteal, S., & North, K. (2003) · The American Journal of Human Genetics · doi:10.1086/377590 · Cited by 905
A Framework for Understanding the Training Process Leading to Elite Performance
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: what do we know, and what do we still need to know?
Levine, B. D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.147629 · Cited by 431
Cardiac Remodeling in Response to 1 Year of Intensive Endurance Training
Arbab-Zadeh, A., Perhonen, M., Howden, E., Peshock, R. M., Zhang, R., Adams-Huet, B., Haykowsky, M. J., & Levine, B. D. (2014) · Circulation · doi:10.1161/circulationaha.114.010775 · Cited by 364
Sayed-Tabatabaei, F. A., Oostra, B. A., Isaacs, A., van Duijn, C. M., & Witteman, J. C. M. (2006) · Circulation Research · doi:10.1161/01.res.0000223145.74217.e7 · Cited by 353
Metadata
- Authors
- Myerson, S., Hemingway, H., Budget, R., Martin, J., Humphries, S., Montgomery, H., & McGloin), (. T. T. A. O. M. M. A. H.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1999-10-01
- Volume
- 87
- Issue
- 4
- Pages
- 1313-1316
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2168366921
- Cited by
- 398
- References
- 30
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
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