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Cited by 306

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Hypertension caused by chronic intermittent hypoxia – influence of chemoreceptors and sympathetic nervous system

Leke, Joachim, Fletcher, Eugene C., Bao, Gang, Unger, Thomas·1997·Journal of Hypertension
DOI 10.1097/00004872-199715120-00060
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Abstract

BACKGROUND: The sleep apnea syndrome (SAS) is a common health problem with a 30% prevalence among patients with so-called essential hypertension. OBJECTIVE: Prompted by this epidemiologic link we tried to find out whether there is a cause-effect relationship between SAS and systemic hypertension. DESIGN: We developed an animal model to simulate defined aspects of the SAS. Rats were exposed to chronic repetitive hypoxia for 7 h per day and their blood pressure was measured by invasive methods. RESULTS: We found that 30 days of intermittent hypoxia sufficed for the development of a significant elevation of blood pressure. The co-exposure to hypoxia and hypercapnia had no additional effect. Surgical denervation of peripheral chemoreceptors prevented the increase in arterial blood pressure. Adrenal demedullation and chemical denervation of the peripheral sympathetic nervous system by 6-hydroxy dopamine also prevented the increase. CONCLUSIONS: Our data imply that repetitive hypoxemia in SAS is probably the cause of the high prevalence of systemic hypertension in this population and that peripheral chemoreceptors and the sympathetic nervous system play important roles in this pathophysiologic process.

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Metadata

Authors
Leke, J., Fletcher, E. C., Bao, G., & Unger, T.
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-12
Volume
15
Issue
12
Pages
1593-1603
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/00004872-199715120-00060
OpenAlex
W2028139576
Cited by
306
References
49
FWCI
0.77
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Hypertension caused by chronic intermittent hypoxia – influence of chemoreceptors and sympathetic nervous system. https://app.cochat.ai/papers/10.1097/00004872-199715120-00060
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Leke, J., Fletcher, E. C., Bao, G., & Unger, T. (1997). Hypertension caused by chronic intermittent hypoxia – influence of chemoreceptors and sympathetic nervous system. Journal of Hypertension. https://doi.org/10.1097/00004872-199715120-00060

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.