Clustering of coronary risk factors with increasing blood pressure at rest and during exercise
Abstract
BACKGROUND: The metabolic cardiovascular syndrome is the label given to the clustering of unfavourable levels of a number of coronary risk factors in subjects with high resting blood pressures. We found recently that exercise blood pressure had a strong independent prognostic value. OBJECTIVE: To search for possible similar associations between exercise blood pressure levels and coronary risk factors by studying conventional and recently acknowledged coronary risk factors. METHODS: The study population comprised 1999 healthy men aged 40-59 years. Age-adjusted coronary risk factor levels and their relation to resting and exercise blood pressures were studied. Resting blood pressure was measured after subjects had rested supine for 5 min. The exercise blood pressure used was the systolic blood pressure measured with the subject sitting on a bicycle ergometer at the end of a work load of 600 kpm/min (100 W) for 6 min. RESULTS: Besides corroborating the relation between the metabolic syndrome and resting blood pressure levels, we observed similar or even stronger associations between levels of various coronary risk factors and exercise blood pressure. We found rather strong, direct associations between exercise blood pressure and total cholesterol level, fasting triglyceride level and body mass index whereas inverse relations were found for glucose tolerance, physical fitness, pulmonary functioning and the ability to increase heart rate during exercise. Virtually all these associations had a level of statistical significance of P<0.001. CONCLUSIONS: High exercise blood pressure levels are strongly associated with unfavourable levels of a number of important coronary risk factors. A similar metabolic syndrome to that observed in subjects with high resting blood pressures therefore appears to be present in subjects with high exercise blood pressure responses. These associations may considerably amplify the independent risk of high blood pressure responses to moderate exercise.
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EEBP appears to cluster with other high-BP related CVD risk factors.
“It is also known that EEBP appears to cluster with other high-BP related CVD risk factors [32].”
From The Identification and Management of High Blood Pressure Using Exercise Blood Pressure: Current Evidence and Practical Guidance (2022) · cites this paper as [32]
Cites
Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data.
Craig, W. Y., Palomaki, G. E., & Haddow, J. E. (1989) · BMJ · doi:10.1136/bmj.298.6676.784 · Cited by 863 · see citing works
Physical Fitness as a Predictor of Mortality among Healthy, Middle-Aged Norwegian Men
Sandvik, L., Erikssen, J., Thaulow, E., Erikssen, G., Mundal, R., & Rodahl, K. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280803 · Cited by 788 · see citing works
Self-citationHow smoking affects blood pressure
Omvik, P. (1996) · Blood Pressure · doi:10.3109/08037059609062111 · Cited by 234 · see citing works
Exercise blood pressure predicts cardiovascular mortality in middle-aged men.
Mundal, R., Kjeldsen, S. E., Sandvik, L., Erikssen, G., Thaulow, E., & Erikssen, J. (1994) · Hypertension · doi:10.1161/01.hyp.24.1.56 · Cited by 210 · see citing works
Self-citationFalse positive diagnostic tests and coronary angiographic findings in 105 presumably healthy males.
Erikssen, J., Enge, I., Forfang, K., et al. (1976) · Circulation · doi:10.1161/01.cir.54.3.371 · Cited by 195 · see citing works
Self-citationExercise Blood Pressure Predicts Mortality From Myocardial Infarction
Mundal, R., Kjeldsen, S. E., Sandvik, L., Erikssen, G., Thaulow, E., & Erikssen, J. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.324 · Cited by 185 · see citing works
Self-citationHeart rate increase and maximal heart rate during exercise as predictors of cardiovascular mortality
Sandvik, L., Erikssen, J., Ellestad, M., Erikssen, G., Thaulow, E., Mundal, R., & Rodahl, K. (1995) · Coronary Artery Disease · doi:10.1097/00019501-199508000-00012 · Cited by 115 · see citing works
Self-citationSandvik, L., Erikssen, G., & Thaulow, E. (1995) · BMJ · doi:10.1136/bmj.311.7007.715 · Cited by 79 · see citing works
Self-citationSerum lipids and latent coronary insufficiency
Erikssen, J. E., & Skrede, S. (1977) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517709091489 · Cited by 67 · see citing works
Self-citationPredictors of 7-year changes in exercise blood pressure
Mundal, R., Kjeldsen, S. E., Sandvik, L., Erikssen, G., Thaulow, E., & Erikssen, J. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715030-00005 · Cited by 47 · see citing works
Self-citationKjeldsen, S. E., Rostrup, M., Moan, A., et al. (1992) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199200208-00008 · Cited by 40 · see citing works
Self-citationErikssen, J., Rasmussen, K., Forfang, K., et al. (1977) · PubMed · Cited by 36 · see citing works
Self-citationTHE PATIENT WITH CORONARY ARTERY DISEASE WITHOUT INFARCTION: CAN A HIGH‐RISK GROUP BE IDENTIFIED?
Erikssen, J., & Mundal, R. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb55236.x · Cited by 26 · see citing works
Self-citationMundal, R., Kjeldsen, S. E., Sandvik, L., et al. (1997) · Blood Pressure · doi:10.3109/08037059709062081 · Cited by 24 · see citing works
Self-citationMeasurement of working capacity by assessment of the aerobic capacity in a single session.
Fh, B. (1966) · PubMed · Cited by 15 · see citing works
Intravenous Glucose Tolerance Test in Middle‐Aged Men with and without Latent Coronary Heart Disease
Erikssen, J., & Enger, S. C. (1977) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1977.tb16843.x · Cited by 12 · see citing works
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Increased Sympathetic Nerve Activity in Renovascular Hypertension
Johansson, M., Elam, M., Rundqvist, B., Eisenhofer, G., Herlitz, H., Lambert, G., & Friberg, P. (1999) · Circulation · doi:10.1161/01.cir.99.19.2537 · Cited by 172 · see citing works
Keller, K., Stelzer, K., Ostad, M. A., & Post, F. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2016.11.010 · Cited by 72 · see citing works
Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing
Schultz, M. G., La Gerche, A., & Sharman, J. E. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000276 · Cited by 36 · see citing works
Schultz, M. G., Currie, K. D., Hedman, K., Climie, R. E., Maiorana, A., Coombes, J. S., & Sharman, J. E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19052819 · Cited by 27 · see citing works
Mariampillai, J. E., Engeseth, K., Kjeldsen, S. E., Grundvold, I., Liestøl, K., Erikssen, G., Erikssen, J., Bodegard, J., & Skretteberg, P. T. (2017) · Blood Pressure · doi:10.1080/08037051.2017.1291276 · Cited by 24 · see citing works
Self-citationMoore, M. N., Climie, R. E., Otahal, P., & Schultz, M. G. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002962 · Cited by 23 · see citing works
- Authors
- Mundal, R., Kjeldsen, S. E., Sandvik, L., Erikssen, G., Thaulow, E., & Erikssen, J.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Kjeldsen, Sverre E.
- Venue
- Journal of Hypertension
- Published
- 1998-01
- Volume
- 16
- Issue
- 1
- Pages
- 19-22
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W1966199823
- Cited by
- 43
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- coronary risk factors, blood pressure response to exercise, resting blood pressure, hypertension, total cholesterol, fasting triglycerides, body mass index, glucose tolerance, physical fitness, lung function, heart rate response to exercise, middle-aged men
- MeSH terms
- Adult, Blood Pressure, Cardiovascular Diseases, Cholesterol, Coronary Disease, Exercise Test, Humans, Hypertension, Male, Middle Aged, Norway, Physical Fitness, Prognosis, Risk Factors, Syndrome, Triglycerides, Exercise, Body Mass Index
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