The DOI matches its Crossref record.
Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys
Abstract
Three rhesus monkeys, whose approximate ages were 16 to 18 years old, and one 22 to 23 years old, were studied for age changes in the nervous system. The brains of all four were slightly shrunken and the meninges were fibrotic. The vessels were stiff and fibrosed, but were not atheromatous. The lateral ventricles were mildly dilated. Bodian preparations of the oldest monkey and of one of the 16− to 18-year-old monkeys revealed the presence of neuritic (senile) plaques. Serial one-micron toluidine blue-stained sections showed that some plaques were closely associated with capillaries. Electron microscopic studies revealed that the plaques were identical to those of human Alzheimer's disease except that the typical twisted tubules were absent. Outside the plaques there were scattered neurites showing degeneration of the type found in the neuritic plaques. Furthermore, two forms of rare pathological fibrillar material were found in 3 animals. One was made up of pairs of helically wound 100 Å filaments with a twist every 500 Å. The other fibrillar structures were made up of bundles of parallel filamentous elements, each about 130 Å thick, with a distinctly granular structure on longitudinal section. A list of other abnormalities includes vascular amyloidosis, lipofuscin accumulation, dark neurons undergoing phagocytosis, myelin remodeling, aggregates of large electron-dense droplets, enlarged mitochondria and mitochondria with paracrystalline inclusions, corpora amylacea, Rosenthal fibers and two types of virus-like particles.
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“The neuropathologic hallmarks of AD are neurofibrillary tangles (NFTs; including pretangles) and AβPs (including diffuse and neuritic plaques, which may also be referred to as “senile plaques” [2, 18, 19]; Fig. 1 and Table 1).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [18]
In the citing paper
“The particular toxic substance(s) within NPs still have not been completely characterized (90, 103, 278), but NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology (18, 50, 279-281).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [18]
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Naturally occurring Alzheimer’s disease in rhesus monkeysPreprint
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Self-citationAuthor’s response to commentaries
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“…mechanisms, such as amyloid-beta deposition and tau hyperphosphorylation — hallmarks of both normal age-related cognitive decline (e.g. 127,133,134 93 Aligning with this, we detected a host of alcohol-related changes in the expression of such markers of dementia-and ADRD-associated…”
Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease
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COMPONENT OF THE AMYLOID DEPOSITS IN ALZHEIMER'S DISEASE
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“Aβ-plaques can be categorized in dense-core also known as neuritic plaques and in diffuse plaques (Wisniewski et al., 1973).”
BackgroundA Non-transgenic Rat Model of Sporadic Alzheimer's Disease
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IMPACTS OF HYPERTENSION AND THROMBOSIS IN A RAT MODEL OF CEREBRAL AMYLOID ANGIOPATHY (rTg-DI)
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“…on age-and alcohol-related changes in ADRD-related genes/proteins in wild-type mice (Hoffman et al., 2019; Liu et al., 2022; Salling et al., 2016; Wisniewski et al., 1973), the present results argue that the age at tissue collection may be important for not only detecting, but also the direction…”
Functional Consequences of Neurofibrillary Degeneration of the Alzheimer Type
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Auboyer, L. (2018) · theses.fr (ABES) · doi:10.70675/07243ef7zb974z4ad8z97d9zd046801798b1
“121 présentent une accumulation d’agrégats Aβ mais de manière plus modeste que celle retrouvée chez les patients (Martin et al., 1991; Walker et al., 1987; Wiśniewski et al., 1973).”
BackgroundThe Use of Localized Proteomics to Understand the Pathogenesis of Alzheimer's Disease
Pires, G. (2021) · theses.fr (ABES) · doi:10.70675/45826fd6zd2c8z4b3dz91e0za5080544cb17
Age-related modulation of γ-secretase activity in non-human primate brains.
西村, 正., 中村, 紳., 遠山, 育., NISHIMURA, M., NAKAMURA, S., Kimura, N., Lei, L. I. U., Suzuki, T., & Tooyama, I. (n.d.) · Institutional Repositories DataBase (IRDB)
Metadata
- Authors
- Wiśniewski, H. M., Ghetti, B., & Terry, R. D.
- Affiliations
- Albert Einstein College of Medicine (US)
- ORCID
- Ghetti, Bernardino
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-10
- Volume
- 32
- Issue
- 4
- Pages
- 566-584
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2090601883
- Cited by
- 272
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2013: 2 · 2012: 4
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuritic plaques, amyloid plaques, Alzheimer's disease, rhesus monkeys, brain aging, fibrillar material, helical filaments, vascular amyloidosis, lipofuscin, myelin remodeling, corpora amylacea, Rosenthal fibers, virus-like particles, mitochondrial inclusions, meningeal fibrosis
- MeSH terms
- Aging, Amyloid, Animals, Haplorhini, Basal Ganglia, Brain, Brain Chemistry, Cerebral Cortex, Dementia, Disease Models, Animal, Female, Humans, Macaca, Male, Medulla Oblongata, Microscopy, Electron, Nerve Degeneration, Neurofibrils, Pons, Spinal Cord
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