Cited by 273Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys

Wiśniewski, Henryk M., Ghetti, Bernardino, Terry, Robert D.·1973·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/00005072-197310000-00007

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Abstract

Three rhesus monkeys, whose approximate ages were 16 to 18 years old, and one 22 to 23 years old, were studied for age changes in the nervous system. The brains of all four were slightly shrunken and the meninges were fibrotic. The vessels were stiff and fibrosed, but were not atheromatous. The lateral ventricles were mildly dilated. Bodian preparations of the oldest monkey and of one of the 16− to 18-year-old monkeys revealed the presence of neuritic (senile) plaques. Serial one-micron toluidine blue-stained sections showed that some plaques were closely associated with capillaries. Electron microscopic studies revealed that the plaques were identical to those of human Alzheimer's disease except that the typical twisted tubules were absent. Outside the plaques there were scattered neurites showing degeneration of the type found in the neuritic plaques. Furthermore, two forms of rare pathological fibrillar material were found in 3 animals. One was made up of pairs of helically wound 100 Å filaments with a twist every 500 Å. The other fibrillar structures were made up of bundles of parallel filamentous elements, each about 130 Å thick, with a distinctly granular structure on longitudinal section. A list of other abnormalities includes vascular amyloidosis, lipofuscin accumulation, dark neurons undergoing phagocytosis, myelin remodeling, aggregates of large electron-dense droplets, enlarged mitochondria and mitochondria with paracrystalline inclusions, corpora amylacea, Rosenthal fibers and two types of virus-like particles.

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Histopathological Studies on Senile Plaques and Cerebral Amyloid Angiopathy in Aged Cynomolgus Monkeys
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“ヒトのアルツハイマー病ではアミロイド β蛋白 (AβP)の沈着を伴う老人斑形成および血管アミロイド症が特徴的に認められる[6,13,14]。また,これらは量的には少ないが正常のヒトにおいても老化に伴いしばしば観察される[13,15]。同様の変化はヒト以外の動物ではサル,イヌ[7,16],コヨーテ[8],クマ [7]に認められている。特にサルではアカゲザル[1, 7,17],カニクイザル[5],コモンリスザル[18]の報告がある。アカゲザル,コ…”
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The Nervous System
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Liberski, P. P. (1987) · Journal of Comparative Pathology · doi:10.1016/0021-9975(87)90125-3 · Cited by 12
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Beal, J. A. (1978) · Journal of Neurocytology · doi:10.1007/bf01173987 · Cited by 12
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Uemura, E., & Ireland, W. P. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90004-4 · Cited by 10
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Ferrer, I. (2024) · Aging · doi:10.18632/aging.206143 · Cited by 10
Drug effects on learning and memory1
Vogel, H. G., Vogel, W. H., Schölkens, B. A., Sandow, J., Müller, G. A., & Vogel, W. F. (2002) · Springer eBooks · doi:10.1007/3-540-29837-1_7 · Cited by 11
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Serotoninergic neurites in senile plaques in cingulate cortex of aged nonhuman primate
Kitt, C. A., Walker, L. C., Molliver, M. E., & Price, D. L. (1989) · Synapse · doi:10.1002/syn.890030103 · Cited by 10

Authors: Wiśniewski, H. M., Ghetti, B., & Terry, R. D.
Affiliations: Albert Einstein College of Medicine (US)
ORCID: Ghetti, Bernardino
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 1973-10
Volume: 32
Issue: 4
Pages: 566-584
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1097/00005072-197310000-00007
OpenAlex: W2090601883
Cited by: 272
References: 0
Citations by year: 2026: 2 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2013: 2 · 2012: 4
FWCI: 8.85
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neuritic plaques, amyloid plaques, Alzheimer's disease, rhesus monkeys, brain aging, fibrillar material, helical filaments, vascular amyloidosis, lipofuscin, myelin remodeling, corpora amylacea, Rosenthal fibers, virus-like particles, mitochondrial inclusions, meningeal fibrosis
MeSH terms: Aging, Amyloid, Animals, Haplorhini, Basal Ganglia, Brain, Brain Chemistry, Cerebral Cortex, Dementia, Disease Models, Animal, Female, Humans, Macaca, Male, Medulla Oblongata, Microscopy, Electron, Nerve Degeneration, Neurofibrils, Pons, Spinal Cord

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Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys

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