Cited by 222Nerve injury and regenerationPeripheral Neuropathies and DisordersNeuroinflammation and Neurodegeneration Mechanisms

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Macrophage Systems in Peripheral Nerves. A Review

GRIFFIN, JOHN W., GEORGE, RACHEL, HO, TONY·1993·Journal of Neuropathology and Experimental Neurology

DOI 10.1097/00005072-199311000-00001

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Abstract

John W. Griffin, Rachel George, Tony Ho; Macrophage Systems in Peripheral Nerves. A Review, Journal of Neuropathology & Experimental Neurology, Volume 52, Issue

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“Such functions of Schwann cells are similar to those in recruited hematogenous macrophages or resident macrophages in Wallerian degeneration.(21,22) In addition, a more recent study showed that cultured cells derived from a spontaneous malignant schwannoma in rats, immunohistochemically showed the features of a macrop…”
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Graft repair of a peripheral nerve without the sacrifice of a healthy donor nerve by the use of acutely dissociated autologous Schwann cells
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“The remaining cells were probably fibroblasts and endothelial cells from blood vessels, which can amount to around 5) of the cells in a peripheral nerve [22].”
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■ REVIEW : LIF, NGF, and the Cell Body Response to Axotomy
Zigmond, R. E. (1997) · The Neuroscientist · doi:10.1177/107385849700300311 · Cited by 35
Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice
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“In peripheral neuropathies, macrophages generally associate with degenerated fibers by invading basal lamina and ingesting axonal and myelin debris [13, 16].”
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“the myelin sheath breakdowns to smaller segments termed ''ovoids'' (Griffin et al. 1993), thus leaving behind a ''footprint'' of a degenerated axon.”
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Li, M., Zhang, P., Guo, W., et al. (2013) · Muscle & Nerve · doi:10.1002/mus.24082 · Cited by 27
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“Two kinds of macrophages are involved in regeneration; resident endoneurial macrophages, which reside within the endoneurium of PNS and are ED-2 (CD163, a cell surface glycoprotein, 175kDa)-positive [39, 40]; and hematogenous monocytes/ macrophages that are ED-1 (CD68, a single chain glycoprotein, 90-110kDa)-positive…”
Background
Comparison of cytokine expression profile during Wallerian degeneration of myelinated and unmyelinated peripheral axons
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“Wallerian degeneration of peripheral nervous system axons triggers a complex cellular response in which macrophages are critically involved (Grif®n et al., 1993; Bruck, 1997).”
Background
Further evidence for a crucial role of resident endoneurial macrophages in peripheral nerve disorders: Lessons from acrylamide‐induced neuropathy
Müller, M., Wacker, K., Getts, D. R., et al. (2008) · Glia · doi:10.1002/glia.20674 · Cited by 23
“…length-dependent axonal degeneration (Fullerton, 1970; Fullerton and In neuropathies, macrophages are the main effector cells and have additional disease-modulating functions (Bruck, 1997; Griffin et al., 1990, 1992, 1993; Kiefer et al., 2001; Kieseier et al., 2006; Martini and Toyka, 2004).”
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Glial Response and Myelin Clearance in Areas of Wallerian Degeneration after Spinal Cord Hemisection in the Monkey Macaca Fascicularis
Shi, F., Zhu, H., Yang, S., Liu, Y., Feng, Y., Shi, J., Xu, D., Wu, W., You, S., Ma, Z., et al. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0706 · Cited by 22
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“Macrophages were responsible for phagocytosis within days of peripheral nerve injury, debris removal, growth factor production, and remodeling of the extracellular matrix of the distal nerve [29,30].”
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Presence of α-globin mRNA and migration of bone marrow cells after sciatic nerve injury suggests their participation in the degeneration/regeneration process
Setton-Avruj, C. P., Musolino, P. L., Salis, C., et al. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.09.024 · Cited by 21
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Saxena, K., Patro, N., & Patro, I. K. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9221-6 · Cited by 20
“Under normal circumstances an immunosuppressant is not expected to alter external regeneration since Wallerian degeneration is not an immune mediated event (Griffin et al. 1993).”
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Hermann, G. E., Hebert, S. L., Meter, M. J. V., et al. (2004) · Brain Research · doi:10.1016/j.brainres.2003.11.078 · Cited by 20
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“Infiltrating non-resident macrophages clear myelin debris in damaged peripheral nerves (Hall and Gregson, 1971; Griffin et al., 1993; Brück, 1997).”
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Background
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“This results from invasion of blood-borne macrophages within the first 3–5 days after injury (Griffin et al., 1993).”
Background
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“After nerve injury, resident macrophages and those recruited from the circulation orchestrate the removal of myelin debris and express factors influencing Schwann cell behavior (Griffin et al., 1993; Bruck, 1997).”
Background
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“As CD4 can also be expressed by macrophages [ 13 ], CD4 + cells were examined but not quantified.”
Background
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Goodearl, A. D. J., Viehöver, A., & Vartanian, T. K. (2001) · Developmental Neuroscience · doi:10.1159/000048693 · Cited by 14
“…of axons as myelinating or nonmyelinating Schwann cells [Salzer and Bunge, 1980; Trapp et al., 1984; Stoll et al., 1989; Chaudhry et al., 1992; Griffin et al., 1993, 1996a, b; Bruck, 1997; Jessen and Mirsky, 3 Neuregulin-Induced Association of erbB2 with Grb2-SOS Dev Neurosci 2001;23:25–30…”
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“This results from invasion of blood borne macrophages within the first 3–5 days after injury (Griffin et al., 1993).”
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“24 Additionally, a small accumulation of macrophages is also observed in the proximal end.”
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Maeda, T., & Ozaki, M. (2014) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.13-00236-1 · Cited by 2
MHC class II antigen-expressing cells in cardiac ganglia of the rat
Kummer, W., Stommel, C., & Grau, V. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0949-8 · Cited by 2
“MHC class II antigen-expressing cells have been detected in the endoneurium of dorsal root ganglia, the superior cervical ganglion, and various peripheral nerves (Craggs and Webster 1985; Graus et al. 1990; Monaco et al. 1992; Griffin et al. 1993; Braun et al. 1993; Vass et al. 1993; Schreiber et al. 1995).”
Background
Introduction to Immune Reactions in the Peripheral Nervous System
Hartung, H., Kieseier, B. C., Gold, R., Stoll, G., & Toyka, K. V. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50028-4 · Cited by 2
Glial Response and Delayed Myelin Clearance in Area of Wallerian Degeneration after Spinal Cord Hemisection in the Monkey (Macaca Fascicularis)
Shi, F., Zhu, H., Yang, S., et al. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008-0706 · Cited by 1
Syndrome douloureux régional complexe: intérêt du couplage de la phase vasculaire de la scintigraphie osseuse au technétium 99 avec l’efficacité de la kétamine
Sorel, M., Lefaucheur, J. P., Béatrix, J.-C., et al. (2012) · La Lettre de médecine physique et de réadaptation · doi:10.1007/s11659-012-0296-1 · Cited by 1
Grundlegendes zu Degeneration und Regeneration von Nerven
Brook, G. A., Hodde, D., & Kretschmer, T. (2014) · Springer eBooks · doi:10.1007/978-3-642-36895-0_1 · Cited by 1
Tissue resident macrophages are sufficient for demyelination during peripheral nerve myelin induced experimental autoimmune neuritis?
Taylor, J. M. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.010 · Cited by 1
Grundlegendes zu Degeneration und Regeneration von Nerven
Brook, G. A., Hodde, D., & Kretschmer, T. (2014) · Springer eBooks · doi:10.1007/978-3-662-45894-5_1 · Cited by 1
Opportunities for Axon Repair in the CNS: Use of Microglia and Biopolymer Compositions
Stopek, J. B., Streit, W. J., & Goldberg, E. P. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4139-1_11 · Cited by 1
A novel role for macrophages in peripheral nerve regeneration
Emmenis, L. V. (2018) · UCL Discovery (University College London) · Cited by 1
The Inflammatory Demyelinating Neuropathies
Midroni, G., & Bilbao, J. M. (1995) · Elsevier eBooks · doi:10.1016/b978-0-7506-9552-7.50014-4 · Cited by 1
Axon Degeneration: Mechanisms and Consequences
Broom, L. J., & Perry, V. H. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1676-1_10

Authors: GRIFFIN, J. W., GEORGE, R., & HO, T.
Affiliations: Johns Hopkins University (US)
Corresponding author: GRIFFIN, JOHN W.
ORCID: HO, TONY
Venue: Journal of Neuropathology and Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 1993-11
Volume: 52
Issue: 6
Pages: 553-560
ISSN: 0022-3069 (ISSN-L)
DOI: 10.1097/00005072-199311000-00001
OpenAlex: W2000601562
Cited by: 222
References: 0
Citations by year: 2025: 3 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 10 · 2013: 7 · 2012: 7
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: macrophages, peripheral nerves, peripheral nerve inflammation, nerve injury, glial cells, neuroinflammation
MeSH terms: Animals, Axons, Cell Differentiation, Cell Division, Demyelinating Diseases, Interferons, Interleukins, Macrophages, Peripheral Nervous System Diseases, Peripheral Nerves, Proto-Oncogene Proteins, Recruitment, Neurophysiological, Tumor Necrosis Factor-alpha, Wallerian Degeneration, Receptors, Colony-Stimulating Factor, Proto-Oncogene Proteins c-kit, Receptor Protein-Tyrosine Kinases, Rats

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Macrophage Systems in Peripheral Nerves. A Review

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