Pharmacological drug treatment of Alzheimer disease: The cholinergic hypothesis revisited

Ladner, Christopher J.; Lee, John M.

doi:10.1097/00005072-199808000-00001

Cited by 146Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Pharmacological drug treatment of Alzheimer disease: The cholinergic hypothesis revisited

Ladner, Christopher J., Lee, John M.·1998·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/00005072-199808000-00001

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Christopher J. Ladner, PhD, John M. Lee, MD, PhD; Pharmacological Drug Treatment of Alzheimer Disease: The Cholinergic Hypothesis Revisited, Journal of Neu

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Reduced acetylcholine is associated with insufficient synthetic action of choline O-acetyltransferase and high catalytic action of acetylcholinesterase, leading to loss of cholinergic transmission at the pre-synaptic level.
“reduced ACh, is associated with an insufficient synthetic action of choline O-acetyltransferase (ChAt) and a high catalytic action of acetylcholinesterase (AChE), finally, lead to the loss of cholinergic transmission at the pre-synaptic level [15].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [15]
The cholinergic hypothesis argues that the reduction of learning and mnemonic processes at the base of Alzheimer's disease is due to low levels of acetylcholine in neurons.
“The cholinergic hypothesis argues that the reduction of learning and mnemonic processes at the base of the disease are due to low levels of ACh in neurons”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [15]

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Authors: Ladner, C. J., & Lee, J. M.
Affiliations: Loyola University Medical Center (US)
Corresponding author: Lee, John M.
ORCID: Lee, John M.
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 1998-08
Volume: 57
Issue: 8
Pages: 719-731
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1097/00005072-199808000-00001
OpenAlex: W2061570982
Cited by: 142
References: 0
Citations by year: 2025: 2 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 1
FWCI: 7.08
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, cholinergic hypothesis, cholinesterase inhibitors, acetylcholinesterase, pharmacotherapy, cholinergic system
MeSH terms: Acetylcholine, Alzheimer Disease, Central Nervous System, Humans, Receptors, Muscarinic, Receptors, Nicotinic

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Pharmacological drug treatment of Alzheimer disease: The cholinergic hypothesis revisited

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