A Prospective Study of Quality of Life in Head and Neck Cancer Patients. Part I: At Diagnosis
Abstract
Purpose A Swedish and Norwegian study was designed to examine health‐related quality of life (HQL) in patients with head and neck cancer (head and neck) at diagnosis and during treatment and rehabilitation. The overall aim was to examine the impact on HQL at diagnosis depending on tumor location, stage, sex, and age (part I) and to describe HQL longitudinally and determine for which patients and during which period HQL deteriorated most (part II). This article presents the results at diagnosis. Method Patients with head and neck cancer at five hospitals in Sweden and Norway were consecutively requested to participate. They were asked to answer the EORTC QLQ‐C30 and QLQ‐H&N35 (the European Organization for Research and Treatment of Cancer, Core 30 questionnaire and head and neck cancer module) repeatedly during 1 year. A total of 357 patients (mean age, 63 y; 72% males) were included. Results Patients with different tumor locations all had their special problems at diagnosis, for example, those with tumors in the larynx with communication, those with oral tumors with pain, and those with pharyngeal tumors with nutrition and pain. The patients with hypopharyngeal cancer reported the worst HQL. Stage appeared to have the strongest impact on HQL. Patients with a more advanced tumor stage reported significantly worse HQL scores for 24 of 32 variables reflecting functioning or problems. The females scored worse than the males for some areas, in particular, emotional functioning. The older patients scored significantly better for emotional and social functioning than patients <65 years but worse for physical functioning and various symptoms. The traditional way of grouping the tumor locations into oral, pharyngeal, laryngeal, and “other” tumors (salivary gland, sinus and nose, and unknown primary) was tested from a HQL point of view and found to be consistent. Conclusions The chosen questionnaires differentiated between different sites of head and neck cancer at diagnosis. Tumor stage had the most powerful impact on HQL score.
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The higher body image distress in females may explain the higher psychological distress experienced by females compared to males [59, 64].
“The higher body image distress in females may also explain the higher psychological distress experienced by females compared to males, in accordance with previous studies [59, 64].”
From Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress (2022) · cites this paper as [59]
The higher presence of oncological pain in females might explain their lower mental QoL [59, 70].
“The higher presence of oncological pain in females might explain their lower mental QoL, in accordance with previous studies [59, 70].”
From Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress (2022) · cites this paper as [59]
Women report more psychological symptoms than men [59].
“These results are in line with a previous study [59] pointing out that women report more psychological symptoms than men; this might indicate a gender difference in our society [59].”
From Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress (2022) · cites this paper as [59]
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Self-citation
- Authors
- Hammerlid, E., Bjordal, K., Ahlner‐Elmqvist, M., Boysen, M., Evensen, J. F., Biörklund, A., Jannert, M., Kaasa, S., Sullivan, M., & Westin, T.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Skåne University Hospital (SE)
- Corresponding author
- Hammerlid, Eva
- Venue
- The Laryngoscope
- Publisher
- Wiley
- Published
- 2001-04
- Volume
- 111
- Issue
- 4
- Pages
- 669-680
- ISSN
- 0023-852X (ISSN-L)
- 1531-4995
- OpenAlex
- W1973812902
- Cited by
- 190
- References
- 39
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 11
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Laryngoscope (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Malmö University Publications (Malmö University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Oral health in cancer treatment
- Keywords
- head and neck cancer, health-related quality of life, tumor location, tumor stage, laryngeal cancer, oral cancer, pharyngeal cancer, hypopharyngeal cancer, sex differences, age differences, EORTC QLQ-C30, QLQ-H&N35, symptom burden, emotional functioning, social functioning, physical function
- MeSH terms
- Aged, Female, Head and Neck Neoplasms, Health Status Indicators, Humans, Male, Middle Aged, Neoplasm Staging, Norway, Prospective Studies, Quality of Life, Surveys and Questionnaires, Sweden
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