Exercise training decreases the growth hormone (GH) response to acute constant-load exercise
Abstract
To assess the influence of exercise training on the growth hormone (GH) response to acute exercise, six untrained males completed a 20-min, high-intensity, constant-load exercise test prior to and after 3 and 6 wk of training (the absolute power output (PO) during each test remained constant x PO = 182.5 +/- 29.5 W). Training increased (pre- vs post-training) oxygen uptake (VO2) at lactate threshold (1.57 +/- 0.33 L.min-1 vs 1.97 +/- 0.24 L.min-1 P < or = 0.05). VO2 at 2.5 mM blood lactate concentration ([HLa]) (1.83 +/- 0.38 L.min-1 vs 2.33 +/- 0.38 L.min-1, P < or = 0.05), and VO2peak (3.15 +/- 0.54 L.min-1 vs 3.41 +/- 0.47 L.min-1, P < or = 0.05). Power output at the lactate threshold (PO-LT) increased with training from 103 +/- 28 to 132 +/- 23W (P < or = 0.05). Integrated GH concentration (20 min exercise + 45 min recovery) (microgram.L-1 x min) after 3 wk (138 +/- 106) and 6 wk (130 +/- 145) were significantly lower (P < or = 0.05) than pre-training (238 +/- 145). Plasma epinephrine and norepinephrine responses to training were similar to the GH response (EPI-pre-training = 2447 +/- 1110; week 3 = 1046 +/- 144; week 6 = 955 +/- 322 pmol.L-1; P < or = 0.05; NE pre-training = 23.0 +/- 5.2; week 3 = 13.4 +/- 4.8; week 6 = 12.1 +/- 6.8 nmol.L-1; P < or = 0.05). These data indicate that the GH and catecholamine response to a constant-load exercise stimulus are reduced within the first 3 wk of exercise training and support the hypothesis that a critical threshold of exercise intensity must be reached to stimulate GH release.
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Aerobic exercise training appears to reduce the acute effect of exercise on GH secretion.
“AET appears to attenuate the acute effect of exercise on GH secretion,282”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [282]
Cites
Veldhuis, J. D., Carlson, M. L., & Johnson, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7686 · Cited by 556 · see citing works
Multiple hormonal responses to graded exercise in relation to physical training.
Hartley, L. H., Mason, J. W., Hogan, R. P., Jones, L. G., Kotchen, T. A., Mougey, E. H., Wherry, F. E., Pennington, L. L., & Ricketts, P. T. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.33.5.602 · Cited by 457 · see citing works
Effect of low and high intensity exercise on circulating growth hormone in men
Felsing, N. E., Brasel, J. A., & Cooper, D. M. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.1.1619005 · Cited by 244 · see citing works
Time course of sympathoadrenal adaptation to endurance exercise training in man
Winder, W. W., Hagberg, J. M., Hickson, R. C., Ehsani, A. A., & McLane, J. A. (1978) · Journal of Applied Physiology · doi:10.1152/jappl.1978.45.3.370 · Cited by 225 · see citing works
WELTMAN, A. L., Weltman, J. Y., Hartman, M. L., Abbott, R. D., Rogol, A. D., Evans, W. S., & Veldhuis, J. D. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126124 · Cited by 199 · see citing works
Self-citationEndurance training amplifies the pulsatile release of growth hormone: effects of training intensity
WELTMAN, A. L., Weltman, J. Y., Schurrer, R. L., Evans, W. S., Veldhuis, J. D., & Rogol, A. D. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.6.2188 · Cited by 198 · see citing works
Self-citationWELTMAN, A. L., Snead, D., Stein, P. D., Seip, R. L., Schurrer, R. L., Rutt, R. A., & Weltman, J. Y. (1990) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024757 · Cited by 197 · see citing works
Self-citationMIKI, N., Ono, M., & SHIZUME, K. (1984) · Endocrinology · doi:10.1210/endo-114-5-1950 · Cited by 192 · see citing works
Growth hormone in exercise: comparison of physiological and pharmacological stimuli
Sutton, J. R., & Lazarus, L. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.523 · Cited by 170 · see citing works
Effect of acid-base balance on the growth hormone response to acute high-intensity cycle exercise
Gordon, S. E., Kraemer, W. J., Vos, N. H., Lynch, J. M., & Knuttgen, H. G. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.2.821 · Cited by 146 · see citing works
Luger, A., Watschinger, B., Deuster, P. A., Svoboda, T., Clodi, M., & Chrousos, G. P. (2008) · Neuroendocrinology · doi:10.1159/000126912 · Cited by 133 · see citing works
Sex and training differences in human growth hormone levels during prolonged exercise
Bunt, J. C., Boileau, R. A., Bahr, J. M., & Nelson, R. A. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.5.1796 · Cited by 117 · see citing works
Slow component of O2 uptake during heavy exercise: adaptation to endurance training
Womack, C. J., Davis, S. E., Blumer, J. L., Barrett, E. J., WELTMAN, A. L., & Gaesser, G. A. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.3.838 · Cited by 112 · see citing works
Self-citationInfluence of physical training on the fuel-hormone response to prolonged low intensity exercise
Koivisto, V. A., Hendler, R., NADEL, E. R., & Felig, P. (1982) · Metabolism · doi:10.1016/0026-0495(82)90135-4 · Cited by 94 · see citing works
Exercise Training at and above the Lactate Threshold in Previously Untrained Women
WELTMAN, A. L., Seip, R., Snead, D., Weltman, J. Y., Haskvitz, E. M., Evans, W., Veldhuis, J. D., & Rogol, A. D. (1992) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021263 · Cited by 90 · see citing works
Self-citationChang, F. E., Dodds, W. G., Sullivan, M., Kim, M. H., & Malarkey, W. B. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-3-551 · Cited by 79 · see citing works
Christensen, S. E., Jørgensen, O. L., Møller, N., & Ørskov, H. (1984) · European Journal of Endocrinology · doi:10.1530/acta.0.1070295 · Cited by 66 · see citing works
Cholinergic and opioid involvement in release of growth hormone during exercise and recovery
Thompson, D. L., Weltman, J. Y., Rogol, A. D., Metzger, D. L., Veldhuis, J. D., & WELTMAN, A. L. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.2.870 · Cited by 63 · see citing works
Self-citationCatecholamine and blood lactate responses to incremental rowing and running exercise
WELTMAN, A. L., Wood, C. M., Womack, C. J., Davis, S. E., Blumer, J. L., Álvarez, J., Sauer, K., & Gaesser, G. A. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.3.1144 · Cited by 62 · see citing works
Self-citationGreater serum GH response to arm than to leg exercise performed at equivalent oxygen uptake
Kozłowski, S., Chwalbinska-Moneta, J., Vigš, M., Kaciuba-Uściłko, H., & Nazar, K. (1983) · European Journal of Applied Physiology · doi:10.1007/bf00429040 · Cited by 52 · see citing works
Devesa, J., DIAZ, M. J., Tresguerres, J. A. F., et al. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-251 · Cited by 43 · see citing works
Regulation of growth hormone during exercise by oxygen demand and availability
Vanhelder, W. P., Casey, K., & Radomski, M. W. (1987) · European Journal of Applied Physiology · doi:10.1007/bf00424801 · Cited by 40 · see citing works
Effect of Adrenergic Blocking Agents on Growth Hormone Responses to Physical Exercise
Sutton, J. R., & Lazarus, L. (1974) · Hormone and Metabolic Research · doi:10.1055/s-0028-1095726 · Cited by 40 · see citing works
Serum Growth Hormone Response to Exercise in Non-Obese and Obese Normal Subjects
Hansen, P. (1973) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517309084307 · Cited by 34 · see citing works
Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin
Sertich, G. J., Persson, L., & Pegg, A. E. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.5.c687 · Cited by 34 · see citing works
Magnan, E., Cataldi, M., Guillaume, V., et al. (1994) · Endocrinology · doi:10.1210/endo.134.2.7905408 · Cited by 30 · see citing works
Weltman, J. Y., Veldhuis, J. D., WELTMAN, A. L., Kerrigan, J. R., Evans, W. S., & Rogol, A. D. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1646 · Cited by 22 · see citing works
Self-citationSeip, R. L. (1990) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1990.02150330058021 · Cited by 12 · see citing works
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Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
Effects of gender on exercise-induced growth hormone release
Wideman, L., Weltman, J. Y., Shah, N., Story, S., Veldhuis, J. D., & Weltman, A. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.3.1154 · Cited by 107 · see citing works
- Authors
- WELTMAN, A., WELTMAN, J. Y., WOMACK, C. J., DAVIS, S. E., BLUMER, J. L., GAESSER, G. A., & HARTMAN, M. L.
- Affiliations
- University of Virginia (US)
- Rainbow Babies & Children's Hospital (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1997-05
- Volume
- 29
- Issue
- 5
- Pages
- 669-676
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W1970287750
- Cited by
- 62
- References
- 28
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag010997-05)
- National Institute on Aging (R01AG10997)
- National Center for Research Resources (RR 00847, M01RR000847)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- exercise training, growth hormone response, acute exercise, constant-load exercise, high-intensity exercise, lactate threshold, oxygen consumption, catecholamines, epinephrine, norepinephrine, training effects, output power, untrained men, blood lactate, peak oxygen uptake, sex differences
- MeSH terms
- Adult, Epinephrine, Humans, Male, Norepinephrine, Oxygen Consumption, Prospective Studies, Time Factors, Exercise, Lactic Acid, Human Growth Hormone
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