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RENAL INSUFFICIENCY AFTER CREATINE SUPPLEMENTATION IN A COLLEGE FOOTBALL ATHLETE
Abstract
1337 HISTORY - A 19-year old Division I football player presented with complaints of fatigue and dyspnea during football practice. He first noticed symptoms one month prior to his examination with progressively worsening complaints and an associated ten pound weight loss. Past history includes asthma treated with inhaled beta-agonists, and no other medial problems (e.g., diabetes, musculoskeletal complaints, rash, or renal disease). Medications: albuterol and nedocromil inhalers, zafirlukast tablets, with no history of anabolic steroid use or non-steroidal antiinflammatory drug use. The patient reported taking 10 grams of creatine monohydrate supplement each day for the past three months. PHYSICAL EXAMINATION - Blood pressure (BP):116/68 mmHg, Heart rate (HR): 72 beats/min. Temperature: 37.1 °C. Weight 116 kg. No orthostatic HR or BP change, no pallor. Cardiovascular (CV): Regular rate and rhythm without murmurs. Lungs: Faint end expiratory wheezing right base. The rest of the physical examination was normal. LABORATORY TESTS: Serum Creatinine =1.7; HCT = 39.5 and MCV = 82.9 FL; CrCI=138 ml/min.; BUN = 18; K+, Na+ = Normal. CK = 996 U/L; Urinalysis = normal. SPIROMETRY: FEV1 = 4.44 L (87%), FVC = 5.28 L (89%). TREATMENT: The patient was placed on aerosolized steroids, continued on prn beta agonists and creatine supplementation was discontinued. No other medications were used and he continued football practice. COURSE: Serum Cr slowly decreased to 1.3 over a one month period, after discontinuing creatine supplementation. Fatigue and dyspnea resolved. ASSESSMENT: To our knowledge, this is the first report of renal insufficiency induced by regular creatine supplementation. The use of this supplement, especially in athletes who regularly use potential nephrotoxins such as NSAIDS, should have their renal function assessed. Further examination of the potential adverse effects of creatine should be examined.
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A few case studies reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction.
“With regard to the question of whether creatine has effect on renal function, a few case studies [249–252] reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction [249–251].”
From International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) · cites this paper as [250]
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Metadata
- Authors
- Kuehl, K., Goldberg, L., & Elliot, D.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1998-05
- Volume
- 30
- Issue
- Supplement
- Pages
- 235
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W1996115062
- Cited by
- 28
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 2 · 2014: 1 · 2013: 1
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Keywords
- creatine monohydrate, creatine supplementation, renal failure, acute kidney injury, creatine kinase, exercise-induced kidney injury, nephrotoxicity
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