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Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial
Abstract
PURPOSE: Despite the potential importance of favorable changes in the lipid profile produced by aerobic exercise, training-induced lipid profile changes in atherosclerosis-prone type 1 diabetes mellitus (DM) have not heretofore been adequately addressed. METHODS: We assessed the effect of a 12- to 16-wk aerobic exercise program on cardiorespiratory fitness and the lipid profile in young men with type 1 DM. Generally active men aged 20-40 yr with type 1 DM (N = 56) were randomized into training (N = 28) and control (untrained, N = 28) groups after baseline measurements. Training consisted of 30-60 min moderate-intensity running 3-5 times a week for 12-16 wk. RESULTS: For the 42 men finishing the study, peak oxygen consumption (VO2 peak) increased significantly only in the trained group. Total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B decreased and the high-density lipoprotein (HDL)/apo A-I ratio increased in the trained group. HDL and apo A-I increased in both groups. The exercise program brought about improvements in the HDL/LDL and apo A-I/apo B ratios and apo B and triglyceride levels when comparing the relative (%) changes in the trained versus control group. In the trained group, men with HDL/LDL ratios below the group median at baseline showed even more favorable changes in their lipid profile than those with higher initial HDL/LDL ratios. Body mass index, percent body fat and hemoglobin A1c did not change during the training period in either group. CONCLUSIONS: Endurance training improved the lipid profile in already physically active type 1 diabetic men, independently of effects on body composition or glycemic control. The most favorable changes were in patients with low baseline HDL/LDL ratios, likely the group with the greatest benefit to be gained by such changes.
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“Crouse et al. [44] and Laaksonen et al. [45] both found that after a few months of aerobic exercise, the concentration of apoB in hypercholesterolemic men decreased.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [45]
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Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514
“Some studies find no improvement in HbA1c with physical training (Wallberg-Henriksson et al., 1984, 1986; Yki-Jarvinen et al., 1984; Laaksonen et al., 2000; Kennedy et al., 2013), whereas other find that the most physically active patients have the lowest HbA1c (Cuenca-Garcia et al., 2012; Carral…”
BackgroundRoss, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486
Evidence for prescribing exercise as therapy in chronic disease
Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384
Lin, X., Zhang, X., Guo, J., Roberts, C. K., McKenzie, S., Wu, W., Liu, S., & Song, Y. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002014 · Cited by 758
Metadata
- Authors
- LAAKSONEN, D. E., ATALAY, M., NISKANEN, L. K., MUSTONEN, J., &NA;, C. K., LAKKA, T. A., & UUSITUPA, M. I. J.
- Affiliations
- University of Eastern Finland (FI)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2000-09
- Volume
- 32
- Issue
- 9
- Pages
- 1541-1548
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2029387172
- Cited by
- 174
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 12 · 2012: 7
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- aerobic exercise, type 1 diabetes, lipid profile, endurance training, cardiorespiratory fitness, peak oxygen uptake, HDL/LDL ratio, apolipoprotein A-I, apolipoprotein B, LDL cholesterol, HDL cholesterol, triglycerides, running, atherosclerosis risk
- MeSH terms
- Adult, Body Composition, Diabetes Mellitus, Type 1, Exercise Therapy, Humans, Lipids, Male, Oxygen Consumption, Physical Fitness
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