Effect of ketoprofen on muscle function and sEMG activity after eccentric exercise
Open accessAbstract
PURPOSE: This study examined whether ketoprofen, a nonsteroidal anti-inflammatory drug, attenuated muscle soreness (SOR), improved maximal isometric force (MIF) recovery, and/or altered myoelectric activity after high-force eccentric exercise. METHODS: 48 subjects were randomly assigned to one of four groups: CON: no exercise/no drug (N = 12); PLA: exercise + placebo (N = 12); TRT-100: exercise + 100 mg oral ketoprofen (N = 12); and TRT-25: exercise + 25 mg oral ketoprofen (N = 12). PLA, TRT-100, and TRT-25 were administered in a double-blind fashion. Baseline measurements of SOR, MIF, and surface electromyographic (EMG) amplitude were taken, and PLA, TRT-100, and TRT-25 performed 50 maximal eccentric contractions of the elbow flexors; 36 h later, subjects reporting moderate soreness were given ketoprofen or placebo and SOR measures were taken hourly for 8 h. EMG amplitude was assessed during MIF before dosing and again 8 h later and during submaximal contractions of 5%, 10%, and 20% of MIF before dosing and hourly for 8 h. RESULTS: Eccentric exercise increased myoelectric activity during submaximal force measurements in PLA, TRT-100, and TRT-25 in all conditions. Ketoprofen had no effect on reducing this increase in EMG activity. Ketoprofen attenuated perceived SOR (P < 0.05) and enhanced MIF recovery (P < 0.05) compared with placebo. TRT-100 and TRT-25 demonstrated 10% and 19% reductions in SOR, respectively, and 16% and 9% increases in MIF, respectively, whereas PLA demonstrated a 1% increase in SOR and 9% decrease in MIF over 8 h. CONCLUSION: Ketoprofen treatment after muscle damaging exercise reduces muscle soreness and improves force recovery.
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Several reports show attenuated exercise-induced muscle inflammation, circulating creatine kinase levels, and muscle soreness when NSAIDs were administered prophylactically before exercise.
“There are several reports of attenuated exercise-induced muscle inflammation, circulating creatine kinase levels, and muscle soreness when NSAIDs were administered prophylactically before exercise [182, 183].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [183]
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- Authors
- SAYERS, S. P., KNIGHT, C. A., CLARKSON, P. M., VAN WEGEN, E. H., & KAMEN, G.
- Affiliations
- University of Massachusetts Amherst (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2001-05
- Volume
- 33
- Issue
- 5
- Pages
- 702-710
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2039722698
- Cited by
- 51
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion, cc-by-nc-nd)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- ketoprofen, nonsteroidal anti-inflammatory drugs, eccentric exercise, delayed onset muscle soreness, muscle soreness, surface electromyography, muscle electrical activity, elbow flexors, post-exercise recovery
- MeSH terms
- Adult, Anti-Inflammatory Agents, Non-Steroidal, Electromyography, Female, Humans, Ketoprofen, Male, Pain, Exercise, Weight-Bearing, Muscle, Skeletal, Muscle Weakness
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