The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Endometriosis and Infertility: New Concepts
Abstract
Endometriosis is a common gynecological disorder with varied symptomatology including chronic pelvic pain, dysmenorrhea, and infertility. The association of endometriosis and infertility has been recognized for years, although definite evidence of causality still eludes us. In this review, we will explore three general concepts that enhance our understanding of the cellular and molecular interactions contributing to the pathophysiology of this disorder and that have steered current research in endometriosis. First, we review evidence of a local peritoneal inflammatory process, supported by the findings of elevated cytokine and growth factor concentrations in peritoneal fluid of affected patients. Second, we propose a role for angiogenic factors in the establishment of ectopic implants. Third, we review evidence for biochemical differences of eutopic and ectopic endometrium in endometriosis patients, which may contribute to both the pathogenesis and sequelae of this important disorder. Through information derived from these research efforts, we hope to develop better therapeutic interventions as adjunctive or alternative therapies to our current medical and surgical armamentarium.
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“Endometriosis is associated with a sterile peritoneal inflammation that results in activation of macrophages that release secretory products, such as cytokines, growth and angiogenic factors”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Ryan and Taylor, 1997
Citations
Cites
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Shifren, J. L., Tseng, J. F., Zaloudek, C. J., Ryan, I., Meng, Y. G., Ferrara, N., Jaffe, R. B., & Taylor, R. N. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768883 · Cited by 656
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Aberrant integrin expression in the endometrium of women with endometriosis
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Cited by
Sorted by citations
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844
Immunobiology of endometriosis
Lebovic, D. I., Mueller, M. D., & Taylor, R. N. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01630-7 · Cited by 857
Self-citationBulun, S. E., Lin, Z., Imir, G., Amin, S., Demura, M., Yilmaz, B., Martin, R., Utsunomiya, H., Thung, S., Gurates, B., et al. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.3.6 · Cited by 531
Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
Stratton, P., & Berkley, K. J. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq050 · Cited by 442
Metadata
- Authors
- Ryan, I. P., & Taylor, R. N.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Taylor, Robert N.
- Venue
- Obstetrical & Gynecological Survey
- Published
- 1997-06
- Volume
- 52
- Issue
- 6
- Pages
- 365-371
- ISSN
- 0029-7828 (ISSN-L)
- OpenAlex
- W2088871668
- Cited by
- 106
- References
- 52
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrical & Gynecological Survey (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, infertility, peritonitis, cytokines, growth factors, angiogenic factors, eutopic endometrium, endometriosis pathophysiology, chronic pelvic pain, dysmenorrhea
- MeSH terms
- Endometriosis, Female, Humans, Infertility, Female
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