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Cited by 330Antifungal resistance and susceptibilityNeonatal and Maternal InfectionsFungal Infections and Studies

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases

KOSSOFF, ERIC H., BUESCHER, E. STEPHEN, KARLOWICZ, M. GARY·1998·The Pediatric Infectious Disease Journal
DOI 10.1097/00006454-199806000-00014
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Abstract

OBJECTIVE: To determine changes in the incidence of candidemia in a neonatal intensive care unit (NICU) during a 15-year period (1981 to 1995) and to compare the prevalence and case fatality rates of Candida albicans and Candida parapsilosis infections. METHODS: A retrospective study was conducted of candidemia occurring in infants in a NICU between January 1, 1981, and December 31, 1995. Cases were identified through computerized searching of a microbiology blood culture database. Candidemia was considered contributory to mortality if death occurred within 3 days of positive blood cultures or if there was autopsy evidence of disseminated candidiasis. RESULTS: One hundred eleven cases of candidemia occurred in 107 infants, representing 1% of all NICU patients during the study period. The rate of candidemia in the NICU increased from 2.5 cases per 1000 admissions in 1981 to 1985, to 4.6 per 1000 admissions in 1986 to 1990 and to 28.5 per 1000 in 1991 to 1995 (P = 0.001). C. albicans was the predominant cause of candidemia between 1981 and 1990. C. parapsilosis was the most prevalent species between 1991 and 1995, causing 53 of 89 cases (60%). The mortality from C. albicans, 13 of 50 cases (26%), was significantly higher than the mortality from C. parapsilosis, 2 of 54 (4%) (P = 0.002; relative risk, 7; 95% confidence interval, 1.7 to 30). CONCLUSIONS: The rate of candidemia in our neonatal intensive care unit increased >11-fold in the 15 years from 1981 to 1995; the prevalent Candida species shifted from C. albicans to C. parapsilosis; and candidemia associated with C. albicans has significantly higher mortality than with C. parapsilosis.

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Crossref · 10.1097/00006454-199806000-00014

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Metadata

Authors
KOSSOFF, E. H., BUESCHER, E. S., & KARLOWICZ, M. G.
Affiliations
Eastern Virginia Medical School (US)
ORCID
KOSSOFF, ERIC H.
Venue
The Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-06
Volume
17
Issue
6
Pages
504-508
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/00006454-199806000-00014
OpenAlex
W1985021288
Cited by
330
References
27
Citations by year
2025: 3 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 13 · 2012: 15
FWCI
11.29
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords
candidemia, neonatal intensive care unit, Candida albicans, Candida parapsilosis, incidence trends, case fatality rate, neonatal mortality, systemic candidiasis, fungemia, infants
MeSH terms
Candida albicans, Candidiasis, Humans, Infant Mortality, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Retrospective Studies, Incidence, Prevalence, Fungemia, Statistics, Nonparametric

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