Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection

FAIX, ROGER G.

doi:10.1097/00006454-199202000-00006

Cited by 123Antifungal resistance and susceptibilityNeonatal and Maternal InfectionsFungal Infections and Studies

Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection

FAIX, ROGER G.·1992·The Pediatric Infectious Disease Journal

DOI 10.1097/00006454-199202000-00006

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Abstract

Severe infections caused by non-albicans Candida species are being increasingly reported among infants in neonatal intensive care units. To assess relative severity, mortality rates for C. albicans (CA) and C. parapsilosis (CP) infections in one neonatal intensive care unit from 1980 to 1990 were compared. Invasive candidiasis was defined as Candida recovery from a normally sterile body fluid or site with clinical signs of infection. Invasive candidiasis was diagnosed and systemic antifungal therapy initiated in 45 infants, 29 with CA and 16 with CP. No differences were found between CA and CP for birth weight, gestational age, age or weight at onset, presence of necrotizing enterocolitis, gastrointestinal or genitourinary anomalies, death (all causes), prior incidence or duration of antibiotics, parenteral nutrition, steroids or endotracheal intubation. Candida infection as the cause of death was more frequent with CA than CP (7 of 29 vs. 0 of 16; P = 0.034). Infants with CA were more likely to have antecedent thrush (P = 0.007) and perineal Candida dermatitis (P less than 0.02); those with CP were more likely to have vascular catheters at the time of positive culture (P less than 0.02). Though both pathogens occur in similar neonatal intensive care unit infants and can cause severe disease, CA appears more likely to result in death than CP.

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In premature neonates or infants with low birth weight and prolonged rupture of cutaneous membranes, the cutaneous process may become invasive and produce acute disseminated candidiasis.
“However, neonates born prematurely or infants with low birth weight and prolonged rupture of cutaneous membranes, the cutaneous process may become invasive and produce acute disseminated candidiasis [165].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [165]

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Authors: FAIX, R. G.
Affiliations: Women's Hospital (US)
Corresponding author: FAIX, ROGER G.
Venue: The Pediatric Infectious Disease Journal
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1992-02
Volume: 11
Issue: 2
Pages: 88-92
ISSN: 0891-3668 (ISSN-L)
DOI: 10.1097/00006454-199202000-00006
OpenAlex: W2067549921
Cited by: 122
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2016: 5 · 2014: 2 · 2013: 8 · 2012: 4
FWCI: 2.54
Type: journal article
Language: en
Open access: closed
Locations: The Pediatric Infectious Disease Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: invasive candidiasis, neonatal candidiasis, Candida albicans, Candida parapsilosis, non-albicans Candida, mortality, antifungal therapy, vascular catheters, necrotizing enterocolitis, neonatal intensive care unit infants
MeSH terms: Candida, Candida albicans, Candidiasis, Female, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male

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Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection

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