The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
INTRAVITREAL BEVACIZUMAB (AVASTIN) TREATMENT OF PROLIFERATIVE DIABETIC RETINOPATHY COMPLICATED BY VITREOUS HEMORRHAGE
Abstract
PURPOSE: To report the short-term anatomic and visual acuity response after intravitreal injection of bevacizumab (Avastin, Genentech) in patients with proliferative diabetic retinopathy complicated by vitreous hemorrhage. METHODS: Two patients with vitreous hemorrhage due to proliferative diabetic retinopathy were treated with at least one intravitreal injection of bevacizumab 1.25 mg in 0.05 mL. The patients underwent Snellen visual acuity testing, ophthalmoscopic examination, and fluorescein angiography at baseline and follow-up visits. RESULTS: Both patients had proliferative diabetic retinopathy with vitreous hemorrhage extensive enough to preclude panretinal photocoagulation. Following intravitreal injection of bevacizumab both patients experienced improvement in visual acuity starting within the first week. At 1 month of follow-up one patient had 2 lines of improvement in visual acuity and the other 5 lines. Each patient had regression of retinal neovascularization at 1 month of follow-up. Repeat injection was given to one patient at the 1-month follow-up because of slight leakage from neovascularization on the nerve, and to the other patient at 3 months because the retinal neovascularization showed early signs of reperfusion. The vitreous hemorrhage in each patient showed partial resolution at 1 week and nearly complete regression at 1 month. No adverse events were observed in either patient. CONCLUSIONS: Initial treatment results of patients with vitreous hemorrhage and proliferative diabetic retinopathy did not reveal any short-term safety concerns. Intravitreal bevacizumab resulted in marked regression of neovascularization and rapid resolution of vitreous hemorrhage. The favorable short-term results suggest further study is needed in a larger group of patients.
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Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
(2007) · Developments in Ophthalmology · doi:10.1159/isbn.978-3-318-01439-6 · Cited by 5,583
Aiello, L. P., Avery, R. L., Arrigg, P. G., Keyt, B. A., Jampel, H. D., Shah, S. T., Pasquale, L. R., Thieme, H., Iwamoto, M. A., Park, J. E., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412013312203 · Cited by 3,793
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
Ferrara, N., Hillan, K. J., Gerber, H.-P., & Novotny, W. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1381 · Cited by 2,625
Adamis, A. P., Miller, J. W., Bernal, M.-T., D'Amico, D. J., Folkman, J., Yeo, T.-K., & Yeo, K.-T. (1994) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)75794-0 · Cited by 1,296
Fong, D. S., Aiello, L. P., Ferris, F. L., & Klein, R. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2540 · Cited by 640
Tolentino, M. J., Miller, J. W., Gragoudas, E. S., Jakobiec, F. A., Flynn, E., Chatzstefanou, K., Ferrara, N., & Adamis, A. P. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30420-x · Cited by 518
Rosenfeld, P. J., Fung, A. E., & Puliafito, C. A. (2005) · Ophthalmic Surgery, Lasers and Imaging Retina · doi:10.3928/1542-8877-20050701-15 · Cited by 489
Pe'er, J., Shweiki, D., Itin, A., Hemo, I., Gnessin, H., & Keshet, E. (1995) · PubMed · Cited by 422
EVOLVING GUIDELINES FOR INTRAVITREOUS INJECTIONS
AIELLO, L. P., BRUCKER, A. J., CHANG, S., CUNNINGHAM, E. T., D’AMICO, D. J., FLYNN, H. W., GRILLONE, L. R., HUTCHERSON, S., LIEBMANN, J. M., O’BRIEN, T. P., et al. (2004) · Retina · doi:10.1097/00006982-200410001-00002 · Cited by 407
Self-citation
Cited by
Management of Diabetic Retinopathy: A Systematic Review
Mohamed, Q., Gillies, M. C., & Wong, T. Y. (2007) · JAMA · doi:10.1001/jama.298.8.902 · Cited by 891
Chakravarthy, U., Harding, S. P., Rogers, C. A., Downes, S. M., Lotery, A. J., Culliford, L. A., & Reeves, B. C. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61501-9 · Cited by 748
Fung, A. E., Rosenfeld, P. J., & Reichel, E. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.099598 · Cited by 532
Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?
Curtis, T. M., Gardiner, T. A., & Stitt, A. W. (2009) · Eye · doi:10.1038/eye.2009.108 · Cited by 393
Bevacizumab and ranibizumab tachyphylaxis in the treatment of choroidal neovascularisation
Gasperini, J. L., Fawzi, A. A., Khondkaryan, A., Lam, L., Chong, L. P., Eliott, D., Walsh, A. C., Hwang, J., & Sadda, S. R. (2012) · British Journal of Ophthalmology · doi:10.1136/bjo.2011.204685 · Cited by 175
Metadata
- Authors
- SPAIDE, R. F., & FISHER, Y. L.
- Venue
- Retina
- Published
- 2006-03
- Volume
- 26
- Issue
- 3
- Pages
- 275-278
- ISSN
- 0275-004X (ISSN-L)
- OpenAlex
- W2029126623
- Cited by
- 507
- References
- 17
- FWCI
- 56.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- SPAIDE, R. F., & FISHER, Y. L. (2006). INTRAVITREAL BEVACIZUMAB (AVASTIN) TREATMENT OF PROLIFERATIVE DIABETIC RETINOPATHY COMPLICATED BY VITREOUS HEMORRHAGE. Retina. https://doi.org/10.1097/00006982-200603000-00004
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