The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Ceftriaxone Therapy for Asymptomatic Neurosyphilis: Case Report and Western Blot Analysis of Serum and Cerebrospinal Fluid IGG Response to Therapy
Abstract
A 27-year-old man with documented hypersensitivity to penicillin was treated intramuscularly for asymptomatic neurosyphilis with ceftriaxone (1 g daily for 14 days). After treatment the serum titer in the VDRL (Venereal Disease Research Laboratory) test declined from 32 to four dilutions. Lumbar punctures at months 3, 6, 9, and 28 after treatment revealed normalization of the cell count in cerebrospinal fluid and a decline in the VDRL titer in cerebrospinal fluid from four to one dilution(s). Western blot analysis revealed the presence in serum of IgG antibodies to at least 17 treponemal antigens and in cerebrospinal fluid of antibodies to at least ten treponemal antigens. Following ceftriaxone therapy serum and cerebrospinal fluid IgG reactivity to all antigens steadily decreased in intensity. These results indicate that ceftriaxone may provide a useful alternative therapy for penicillin-allergic patients with neurosyphilis.
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In the citing paper
“Limited data indicate that ceftriaxone 1–2 g daily either IM or IV for 10–14 days can be used as an alternative treatment for persons with neurosyphilis (603,616,617).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [616]
In the citing paper
“Several different ceftriaxone regimens have been shown to be effective for the treatment of early syphilis.104–113”
From BASHH UK guidelines for the management of syphilis 2024 (2024) · cites this paper as [106]
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
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Antigens of Treponema pallidum Recognized by IgG and IgM Antibodies During Syphilis in Humans
BAKER-ZANDER, S. A., Hook, E. W., Bonin, P., et al. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/151.2.264 · Cited by 113
Self-citationLukehart, S. A., BAKER-ZANDER, S. A., & Sell, S. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.1.454 · Cited by 107
Self-citationIdentification of Treponema pallidum antigens: comparison with a nonpathogenic treponeme.
Lukehart, S. A., BAKER-ZANDER, S. A., & Gubish, E. R. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.2.833 · Cited by 97
Self-citationAntimicrobial Agents and the Central Nervous System
Everett, D., & Strausbaugh, L. J. (1980) · Neurosurgery · doi:10.1227/00006123-198006000-00016 · Cited by 77
Johnson, R. C., Bey, R., & Wolgamot, S. J. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.6.984 · Cited by 56
Effect of cortisone administration on host-parasite relationships in early experimental syphilis.
Lukehart, S. A., BAKER-ZANDER, S. A., Lloyd, R. M. C., & Sell, S. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.4.1361 · Cited by 46
Self-citationRationale for clinical trials evaluating ceftriaxone in the therapy of bacterial meningitis.
Wm, S., Rocha, H., Ma, S., & Jp, B. (1984) · PubMed · Cited by 28
Parenteral Cephaloridine Treatment of Patients With Early Syphilis
GLICKSMAN, J. M. (1968) · Archives of Internal Medicine · doi:10.1001/archinte.1968.03640040036007 · Cited by 16
Cephalexin Therapy for Infectious Syphilis
Duncan, W. C. (1974) · Archives of Dermatology · doi:10.1001/archderm.1974.01630070045008 · Cited by 12
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Marra, C. M., Boutin, P., McArthur, J. C., Hurwitz, S., Simpson, G., Haslett, J. P. A., van der Horst, C., Nevin, T., Hook, E. W., & AIDS Clinical Trials Group (ACTG) 145 Team (2000) · Clinical Infectious Diseases · doi:10.1086/313725 · Cited by 194
Self-citationMarra, C. M., Maxwell, C. L., Tantalo, L. C., Sahi, S. K., & Lukehart, S. A. (2008) · Clinical Infectious Diseases · doi:10.1086/591534 · Cited by 159
“doxycycline or ceftriaxone are also sometimes used, but there are few data on the efficacy of these regimens [5-8].”
BackgroundDowell, M. E., Ross, P. G., Musher, D. M., Cate, T. R., & Baughn, R. E. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90574-u · Cited by 133
Treatment of neurosyphilis with ceftriaxone.
Shann, S. (2003) · Sexually Transmitted Infections · doi:10.1136/sti.79.5.415 · Cited by 76
Metadata
- Authors
- HOOK, E. W., BAKER-ZANDER, S. A., MOSKOVITZ, B. L., LUKEHART, S. A., & HANDSFIELD, H. H.
- Affiliations
- University of Washington (US)
- Public Health – Seattle & King County (US)
- Corresponding author
- HOOK, EDWARD W.
- BAKER-ZANDER, SHARON A.
- LUKEHART, SHEILA A.
- HANDSFIELD, H. HUNTER
- Venue
- Sexually Transmitted Diseases
- Published
- 1986-07
- Volume
- 13
- Issue
- 3
- Pages
- 185-188
- ISSN
- 0148-5717 (ISSN-L)
- OpenAlex
- W2079059511
- Cited by
- 66
- References
- 11
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 4 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sexually Transmitted Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 18988)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- ceftriaxone, asymptomatic neurosyphilis, penicillin allergy, intramuscular antibiotic therapy, cerebrospinal fluid, VDRL titers, Western blot, syphilis treatment
- MeSH terms
- Adult, Animals, Ceftriaxone, Cerebrospinal Fluid, Humans, Immunoglobulin G, Male, Neurosyphilis, Rabbits, Syphilis Serodiagnosis
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