Treatment of neurosyphilis with ceftriaxone.
Open accessAbstract
The first choice treatment for late syphilis is penicillin. Other than doxycycline, which penetrates the CNS, there are few alternatives for the treatment of neurosyphilis. We report a case of successful treatment of symptomatic neurosyphilis with parenteral ceftriaxone.
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Ceftriaxone 1-2 g daily either IM or IV for 10-14 days can be used as an alternative treatment for persons with neurosyphilis.
“Limited data indicate that ceftriaxone 1–2 g daily either IM or IV for 10–14 days can be used as an alternative treatment for persons with neurosyphilis (603,616,617).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [617]
The Case Report describes successful treatment with 1 g of ceftriaxone daily for 14 days, and the Discussion specifies three days IV followed by 11 days IM. The Discussion suggests ceftriaxone may be an alternative, but does not establish the full 1–2 g, 10–14-day regimen and cautions that efficacy in patients with HIV coinfection is uncertain. (LLM, conf=0.88)
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Cites
Sexually Transmitted Diseases Treatment Guidelines, 2006
SKOLNIK, N. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-313-4_17 · Cited by 3,129 · see citing works
Sexually transmitted diseases treatment guidelines
Burstein, G. R., & Workowski, K. (2003) · Current Opinion in Pediatrics · doi:10.1097/00008480-200308000-00006 · Cited by 2,077 · see citing works
Marra, C. M., Boutin, P., McArthur, J. C., Hurwitz, S., Simpson, G., Haslett, J. P. A., van der Horst, C., Nevin, T., Hook, E. W., & AIDS Clinical Trials Group (ACTG) 145 Team (2000) · Clinical Infectious Diseases · doi:10.1086/313725 · Cited by 194 · see citing works
European guideline for the management of syphilis
Goh, B. T., & Vader, P. C. V. V. (2001) · International Journal of STD & AIDS · doi:10.1258/0956462011924065 · Cited by 148 · see citing works
Dowell, M. E., Ross, P. G., Musher, D. M., Cate, T. R., & Baughn, R. E. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90574-u · Cited by 133 · see citing works
HOOK, E. W., BAKER-ZANDER, S. A., MOSKOVITZ, B. L., LUKEHART, S. A., & HANDSFIELD, H. H. (1986) · Sexually Transmitted Diseases · doi:10.1097/00007435-198607000-00018 · Cited by 66 · see citing works
Ceftriaxone therapy of meningitis and serious infections.
Steele, R. W. (1984) · PubMed · Cited by 34 · see citing works
Evaluation of Aqueous Penicillin G and Ceftriaxone for Experimental Neurosyphilis
Marra, C. M., Slatter, V., Tartaglione, T. A., Baker-Zander, S. A., & Lukehart, S. A. (1992) · Journal of Infectious Diseases · doi:10.1093/infdis/165.2.396 · Cited by 27 · see citing works
Syphilitic Meningomyelitis Treated with Ceftriaxone: Case Report
Gentile, J. H., Viviani, C., Sparo, M. D., & Arduino, R. C. (1998) · Clinical Infectious Diseases · doi:10.1086/517112 · Cited by 20 · see citing works
Hahn, R. D., Webster, B., Weickhardt, G. D., et al. (1958) · Journal of Chronic Diseases · doi:10.1016/0021-9681(58)90027-4 · Cited by 17 · see citing works
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Research works printed but not linked: 1
- Hahn RD, Webster B, Weickhardt G, et al. The results of treatment of 1086 general paralytics the majority of whom were followed up for more than 5 years. J Chron Dis 1958;7:209-27.
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
A study evaluating ceftriaxone as a treatment agent for primary and secondary syphilis in pregnancy.
Zhou, P., Gu, Z., Xu, J., Wang, X., & Liao, K. (2005) · Sexually Transmitted Diseases · doi:10.1097/01.olq.0000170443.70739.cd · Cited by 49 · see citing works
Cao, Y., Su, X., Wang, Q., Xue, H., Zhu, X., Zhang, C., Jiang, J., Qi, S., Gong, X., Zhu, X., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix611 · Cited by 51 · see citing works
BASHH UK guidelines for the management of syphilis 2024
Kingston, M., Apea, V., Evans, C., Fifer, H., Foster, K., Patrick, P., Grant, A., Manns, V., Ramsden, S., Sinka, K., et al. (2024) · International Journal of STD & AIDS · doi:10.1177/09564624241280406 · Cited by 51 · see citing works
- Authors
- Shann, S.
- Affiliations
- Leeds General Infirmary (GB)
- Corresponding author
- Shann, S
- Venue
- Sexually Transmitted Infections
- Publisher
- BMJ
- Published
- 2003-10-01
- Volume
- 79
- Issue
- 5
- Pages
- 415-416
- ISSN
- 0007-134X (ISSN-L)
- 1368-4973
- PMC
- PMC1744761
- OpenAlex
- W2167757726
- Cited by
- 76
- References
- 10
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2015: 10 · 2014: 6 · 2013: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Sexually Transmitted Infections (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- neurosyphilis, ceftriaxone, late syphilis, parenteral antibiotics, CNS penetration, doxycycline
- MeSH terms
- Antitreponemal Agents, Ceftriaxone, Humans, Male, Middle Aged, Neurosyphilis, Treatment Outcome
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