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Cited by 194Syphilis Diagnosis and TreatmentInfectious Diseases and TuberculosisHistorical Medical Research and Treatments

A pilot study evaluating ceftriaxone and penicillin G as treatment agents for neurosyphilis in human immunodeficiency virus-infected individuals.

Marra, C. M., Boutin, P., McArthur, J. C., Hurwitz, S., Simpson, G., Haslett, J. P. A., van der Horst, C., Nevin, T. +2 more·2000·Clinical Infectious Diseases
DOI 10.1086/313725
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Abstract

To compare intravenous (iv) ceftriaxone and penicillin G as therapy for neurosyphilis, blood and CSF were collected before and 14-26 weeks after therapy from 30 subjects infected with human immunodeficiency virus (HIV)-1 who had (1) rapid plasma reagin (RPR) test titers >/=1&rcolon;16, (2) reactive serum treponemal tests, and (3) either reactive CSF-Venereal Disease Research Laboratory (VDRL) tests or CSF abnormalities: (a) CSF WBC values >/=20/microL or (b) CSF protein values >/=50 mg/dL. At baseline, more ceftriaxone recipients had skin symptoms and signs (6 [43%] of 14 vs. 1 [6%] of 16; P=.03), and more penicillin recipients had a history of neurosyphilis (7 [44%] of 16 vs. 1 [7%] of 14; P=.04). There was no difference in the proportion of subjects in each group whose CSF measures improved. Significantly more ceftriaxone recipients had a decline in serum RPR titers (8 [80%] of 10 vs. 2 [13%] of 15; P=. 003), even after controlling for baseline RPR titer, skin symptoms and signs, or prior neurosyphilis were controlled for. Differences in the 2 groups limit comparisons between them. However, iv ceftriaxone may be an alternative to penicillin for treatment of HIV-infected patients with neurosyphilis and concomitant early syphilis.

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Crossref · 10.1086/313725

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  • Small observational studies conducted among persons with HIV and neurosyphilis report that ceftriaxone 1-2 g IV daily for 10-14 days might be effective as an alternative agent.

    “Small observational studies conducted among persons with HIV and neurosyphilis report that ceftriaxone 1–2 g IV daily for 10–14 days might be effective as an alternative agent (628–630).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [628]

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Authors
Marra, C. M., Boutin, P., McArthur, J. C., Hurwitz, S., Simpson, G., Haslett, J. P. A., van der Horst, C., Nevin, T., Hook, E. W., & AIDS Clinical Trials Group (ACTG) 145 Team
Affiliations
  • University of Washington (US)
  • Johns Hopkins University (US)
  • Harvard University (US)
  • University of California, Los Angeles (US)
  • New York University (US)
  • National Institute of Allergy and Infectious Diseases (US)
  • University of Alabama at Birmingham (US)
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2000-03-01
Volume
30
Issue
3
Pages
540-544
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/313725
OpenAlex
W2139553095
Cited by
194
References
22
Citations by year
2026: 2 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 15 · 2014: 14 · 2013: 5 · 2012: 4
FWCI
3.07
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (AI-27664, U01AI027664)
  • National Institute of Neurological Disorders and Stroke (NS 34235, R01NS034235)
Topics
  • Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
Keywords
neurosyphilis, HIV infection, ceftriaxone, penicillin G, syphilis treatment, early syphilis, RPR titer
MeSH terms
Adult, Ceftriaxone, Cephalosporins, Female, Humans, Male, Middle Aged, Neurosyphilis, Penicillin G, Penicillins, Pilot Projects, HIV Infections

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