The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Advances in Secondary Spinal Cord Injury: Role of Apoptosis
Abstract
The outcome of spinal cord injury depends on the extent of secondary damage produced by a series of cellular and molecular events initiated by the primary trauma. This article reviews the evidence that secondary spinal cord injury involves the apoptotic as well as necrotic death of neurons and glial cells. Also discussed are the major factors that can contribute to cell death, such as glutamatergic excitotoxicity, free radical damage, cytokines, and inflammation. The development of innovative therapeutic strategies to reduce secondary spinal cord injury depends on an increased understanding of secondary injury mechanisms at the molecular and biochemical level. Such therapeutic interventions may include the use of antiapoptotic drugs, free radical scavengers, and anti-inflammatory agents. These could be targeted to block key reactions on cellular and molecular injury cascades, thus reducing secondary tissue damage, minimizing side effects, and improving functional recovery.
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Citations
Cites
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
Faden, A. I., Demediuk, P., Panter, S. S., & Vink, R. (1989) · Science · doi:10.1126/science.2567056 · Cited by 1,508
Cited by
Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis
Feng, S.-Q., Yao, X., Zhang, Y., Hao, J., Duan, H.-Q., Zhao, C.-X., Sun, C., Li, B., Fan, B.-Y., Wang, X., et al. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.245480 · Cited by 298
Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death
Kanno, H., Ozawa, H., Sekiguchi, A., & Itoi, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.009 · Cited by 135
Kanno, H., Ozawa, H., Sekiguchi, A., Yamaya, S., & Itoi, E. (2011) · Spine · doi:10.1097/brs.0b013e3182028c3a · Cited by 131
Pang, A.-L., Xiong, L.-L., Xia, Q.-J., Liu, F., Wang, Y.-C., Liu, F., Zhang, P., Meng, B.-L., Tan, S., & Wang, T.-H. (2017) · Cell Transplantation · doi:10.1177/0963689717715168 · Cited by 35
Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury
Pajoohesh-Ganji, A., Burns, M. P., Pal-Ghosh, S., Tadvalkar, G., Hokenbury, N. G., Stepp, M. A., & Faden, A. I. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.049 · Cited by 29
Metadata
- Authors
- Lu, J., Ashwell, K. W. S., & Waite, P.
- Venue
- Spine
- Published
- 2000-07
- Volume
- 25
- Issue
- 14
- Pages
- 1859-1866
- ISSN
- 0362-2436 (ISSN-L)
- OpenAlex
- W2047369546
- Cited by
- 256
- References
- 1
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lu, J., Ashwell, K. W. S., & Waite, P. (2000). Advances in Secondary Spinal Cord Injury: Role of Apoptosis. Spine. https://doi.org/10.1097/00007632-200007150-00022
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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