The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION: Suppression of Allograft Rejection by Blockade of the CD40-gp39 Pathway1
Abstract
Studies in vivo have documented the importance of CD40-gp39 interactions in the development of T-dependent antibody responses to foreign and auto-antigens. In this report, we demonstrate that allograft rejection is also associated with strong induction of CD40 and gp39 transcripts. When treatment was initiated at the time of transplant, MR1, a mAb specific for gp39, induced markedly prolonged survival of fully disparate murine cardiac allografts in both naive and sensitized hosts. However, when therapy was delayed until postoperative day 5, anti-gp39 failed to prolong graft survival. Allografts from recipients treated with MR1 from the time of transplantation showed decreased expression of transcripts for the macrophage effector molecule, inducible nitric oxide synthase, but essentially unaltered expression of B7 molecules and T cell cytokine transcripts (interleukin [IL]-2, interferon-gamma, IL-10, and IL-4) relative to control allografts. In addition, alloantibody responses in the MR1-treated mice were profoundly inhibited. However, our studies using B cell-deficient mice indicated that the ability of MR1 to prolong allograft survival was not dependent on B cells. These data suggest that blockade of CD40-gp39 interactions may inhibit allograft rejection primarily by interfering with T cell help for effector functions, rather than by interference with T cell activation.
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Cites
Tolerance, Danger, and the Extended Family
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Cited by
Molecular mechanism and function of CD40/CD40L engagement in the immune system
Elgueta, R., Benson, M. J., De Vries, V. C., Wasiuk, A., Guo, Y., & Noelle, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00782.x · Cited by 1,625
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
Larsen, C. P., Elwood, E. T., Alexander, D. Z., Ritchie, S. C., Hendrix, R., Tucker-Burden, C., Cho, H. R., Aruffo, A., Hollenbaugh, D., Linsley, P. S., et al. (1996) · Nature · doi:10.1038/381434a0 · Cited by 1,455
Self-citationMechanism of cellular rejection in transplantation
Ingulli, E. (2010) · Pediatric Nephrology · doi:10.1007/s00467-008-1020-x · Cited by 313
Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
Sidiropoulos, P. I., & Boumpas, D. T. (2004) · Lupus · doi:10.1191/0961203304lu1032oa · Cited by 178
Metadata
- Authors
- Larsen, C. P., Alexander, D. Z., Hollenbaugh, D., Elwood, E. T., Ritchie, S. C., Aruffo, A., Hendrix, R., & Pearson, T. C.
- Venue
- Transplantation
- Published
- 1996-01
- Volume
- 61
- Issue
- 1
- Pages
- 4-9
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2068225706
- Cited by
- 323
- References
- 29
- FWCI
- 32.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION: Suppression of Allograft Rejection by Blockade of the CD40-gp39 Pathway1. https://app.cochat.ai/papers/10.1097/00007890-199601150-00002
- The paper
- Larsen, C. P., Alexander, D. Z., Hollenbaugh, D., Elwood, E. T., Ritchie, S. C., Aruffo, A., Hendrix, R., & Pearson, T. C. (1996). CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION: Suppression of Allograft Rejection by Blockade of the CD40-gp39 Pathway1. Transplantation. https://doi.org/10.1097/00007890-199601150-00002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
