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Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
Abstract
Huntington's disease is a progressive, degenerative disease characterized by abnormal body movements called chorea, and a reduction of various mental abilities. 3-Nitropropionic acid, an inhibitor of complex II of the electron transport chain, causes Huntington's disease-like symptoms in rodents. Recently, it has been reported that oxidative stress, which is one of the pathological hallmarks of various neurodegenerative disorders, also plays an important role in the pathogenesis of Huntington's disease. The present study was designed to investigate effects of resveratrol, an antioxidant with cyclooxygenase I inhibitory activity, in the 3-nitropropionic acid-induced model of Huntington's disease. Intraperitoneal administration of 3-nitropropionic acid (20 mg/kg for 4 days) caused significant loss of body weight, a decline in motor function (locomotor activity, movement pattern and vacuous chewing movements) and poor retention of memory. Repeated treatment with resveratrol (5 and 10 mg/kg, orally), once daily for a period of 8 days beginning 4 days prior to 3-nitropropionic acid administration, significantly improved the 3-nitropropionic acid-induced motor and cognitive impairment. Biochemical analysis revealed that systemic 3-nitropropionic acid administration significantly increased lipid peroxidation, nitrite levels, and depleted reduced glutathione levels, and decreased succinate dehydrogenase activity in the brains of rats. The results of the present study indicate that resveratrol (5 and 10 mg/kg, orally) significantly reversed 3-nitropropionic acid-induced motor and cognitive impairment, and that the beneficial effects of resveratrol might be attributed to its antioxidant activity.
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“Resveratrol also protects against 3-NP induced motor and behavioral deficits198.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [198]
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Cites
Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Mechanisms of lipid peroxide formation in animal tissues
Wills, E. D. (1966) · Biochemical Journal · doi:10.1042/bj0990667 · Cited by 1,355
Mitochondrial dysfunction in neurodegenerative diseases
Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 611
Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
Frautschy, S. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00300-1 · Cited by 514
3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin
Ludolph, A. C., He, F., Spencer, P. S., Hammerstad, J. P., & Sabri, M. I. (1991) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100032212 · Cited by 484
Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356
Sharma, M., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02083-0 · Cited by 326
Han, Y.-S., Zheng, W., Bastianetto, S., Chabot, J., & Quirion, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705688 · Cited by 300
Stojanović, S., SPRINZ, H., & Brede, O. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2388 · Cited by 275
Research works printed but not linked: 1
- Zini, 1999, Drugs Exp Clin Res, 25, 87
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Bhosle, P. V., & Wadher, S. J. (2025) · Journal of Neurosciences in Rural Practice · doi:10.25259/jnrp_20_2025 · Cited by 1
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Metadata
- Authors
- Kumar, P., Padi, S. S., Naidu, P. S., & Kumar, A.
- Affiliations
- Panjab University (IN)
- Corresponding author
- Kumar, Puneet
- Kumar, Anil
- Venue
- Behavioural Pharmacology
- Published
- 2006-09
- Volume
- 17
- Issue
- 5-6
- Pages
- 485-492
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1974431794
- Cited by
- 167
- References
- 36
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 16 · 2012: 12
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- resveratrol, 3-nitropropionic acid, Huntington's disease, neuroprotection, oxidative stress, antioxidant activity, motor impairment, cognitive impairment, lipid peroxidation, glutathione depletion, nitrite, succinate dehydrogenase, complex II inhibition
- MeSH terms
- Resveratrol, Animals, Antioxidants, Behavior, Animal, Brain, Cell Survival, Glutathione, Huntington Disease, Injections, Intraperitoneal, Male, Motor Activity, Neurons, Neurotoxins, Nitro Compounds, Propionates, Retention, Psychology, Stereotyped Behavior, Stilbenes, Succinate Dehydrogenase, Lipid Peroxidation, Rats, Wistar, Neuroprotective Agents, Rats
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