Cited by 514Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

Frautschy, S·2001·Neurobiology of Aging

Abstract

Both oxidative damage and inflammation have been implicated in age-related neurodegenerative diseases including Alzheimer's Disease (AD). The yellow curry spice, curcumin, has both antioxidant and anti-inflammatory activities which confer significant protection against neurotoxic and genotoxic agents. We used 22 month Sprague-Dawley (SD) rats to compare the effects of the conventional NSAID, ibuprofen, and curcumin for their ability to protect against amyloid beta-protein (Abeta)-induced damage. Lipoprotein carrier-mediated, intracerebroventricular infusion of Abeta peptides induced oxidative damage, synaptophysin loss, a microglial response and widespread Abeta deposits. Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss. Both ibuprofen and curcumin reduced microgliosis in cortical layers, but curcumin increased microglial labeling within and adjacent to Abeta-ir deposits. In a second group of middle-aged female SD rats, 500 ppm dietary curcumin prevented Abeta-infusion induced spatial memory deficits in the Morris Water Maze and post-synaptic density (PSD)-95 loss and reduced Abeta deposits. Because of its low side-effect profile and long history of safe use, curcumin may find clinical application for AD prevention.

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Crossref · 10.1016/s0197-4580(01)00300-1

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Authors
Frautschy, S.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Frautschy, S
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2001-12
Volume
22
Issue
6
Pages
993-1005
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2147532876
Cited by
514
References
83
Citations by year
2026: 5 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 10 · 2021: 16 · 2020: 22 · 2019: 27 · 2018: 13 · 2017: 18 · 2016: 30 · 2015: 17 · 2014: 26 · 2013: 19 · 2012: 36
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (U01AG028583, P50AG016570, AG 16570, R01AG010685, AG10685)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
curcumin, ibuprofen, amyloid-beta, Alzheimer's disease, oxidative stress, neuroinflammation, microglial activation, synaptophysin, PSD-95, spatial memory impairment, isoprostanes, dietary supplementation, neuroprotection
MeSH terms
Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Brain, Brain Chemistry, Cognition Disorders, Curcumin, Diet, Enzyme-Linked Immunosorbent Assay, Ibuprofen, Image Interpretation, Computer-Assisted, Immunohistochemistry, Injections, Neurotoxins, Oxidation-Reduction, Peptide Fragments, Phenols, Amyloid beta-Peptides, Synaptophysin, Maze Learning, Molecular Chaperones, Plaque, Amyloid

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