The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
Abstract
Huntington's disease is a progressive, degenerative disease characterized by abnormal body movements called chorea, and a reduction of various mental abilities. 3-Nitropropionic acid, an inhibitor of complex II of the electron transport chain, causes Huntington's disease-like symptoms in rodents. Recently, it has been reported that oxidative stress, which is one of the pathological hallmarks of various neurodegenerative disorders, also plays an important role in the pathogenesis of Huntington's disease. The present study was designed to investigate effects of resveratrol, an antioxidant with cyclooxygenase I inhibitory activity, in the 3-nitropropionic acid-induced model of Huntington's disease. Intraperitoneal administration of 3-nitropropionic acid (20 mg/kg for 4 days) caused significant loss of body weight, a decline in motor function (locomotor activity, movement pattern and vacuous chewing movements) and poor retention of memory. Repeated treatment with resveratrol (5 and 10 mg/kg, orally), once daily for a period of 8 days beginning 4 days prior to 3-nitropropionic acid administration, significantly improved the 3-nitropropionic acid-induced motor and cognitive impairment. Biochemical analysis revealed that systemic 3-nitropropionic acid administration significantly increased lipid peroxidation, nitrite levels, and depleted reduced glutathione levels, and decreased succinate dehydrogenase activity in the brains of rats. The results of the present study indicate that resveratrol (5 and 10 mg/kg, orally) significantly reversed 3-nitropropionic acid-induced motor and cognitive impairment, and that the beneficial effects of resveratrol might be attributed to its antioxidant activity.
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“Resveratrol also protects against 3-NP induced motor and behavioral deficits198.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [198]
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Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
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Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00141 · Cited by 449
What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol
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Metadata
- Authors
- Kumar, P., Padi, S. S., Naidu, P. S., & Kumar, A.
- Affiliations
- Panjab University (IN)
- Corresponding author
- Kumar, Puneet
- Kumar, Anil
- Venue
- Behavioural Pharmacology
- Published
- 2006-09
- Volume
- 17
- Issue
- 5-6
- Pages
- 485-492
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1974431794
- Cited by
- 167
- References
- 36
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 16 · 2012: 12
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- resveratrol, 3-nitropropionic acid, Huntington's disease, neuroprotection, oxidative stress, antioxidant activity, motor impairment, cognitive impairment, lipid peroxidation, glutathione depletion, nitrite, succinate dehydrogenase, complex II inhibition
- MeSH terms
- Resveratrol, Animals, Antioxidants, Behavior, Animal, Brain, Cell Survival, Glutathione, Huntington Disease, Injections, Intraperitoneal, Male, Motor Activity, Neurons, Neurotoxins, Nitro Compounds, Propionates, Retention, Psychology, Stereotyped Behavior, Stilbenes, Succinate Dehydrogenase, Lipid Peroxidation, Rats, Wistar, Neuroprotective Agents, Rats
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