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Cited by 126Diabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

The DOI matches its Crossref record.

Small, dense low density lipoproteins, the insulin resistance syndrome and noninsulin-dependent diabetes

Austin, Melissa A., Edwards, Karen L.·1996·Current Opinion in Lipidology
DOI 10.1097/00041433-199606000-00010
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Abstract

The role of small, dense LDL as a risk factor for coronary heart disease is becoming well established. Several atherogenic mechanisms have been proposed to explain this relationship, including the association of small, dense LDL with the insulin resistance syndrome. A variety of studies, including large epidemiologic investigations, have now demonstrated that a predominance of small, dense LDL is one of the constellation of interrelated risk factors that characterize the insulin resistance syndrome. Recent results using a multivariate factor analysis approach have also shown that this set of risk factors can be simplified into three or four uncorrelated components that may provide new insights into the mechanisms underlying the syndrome and its association with disease. Furthermore, a number of cross-sectional studies and one prospective study have shown that small, dense LDL is a risk factor for noninsulin-dependent diabetes itself, and that this association may also be attributable to the insulin resistance syndrome.

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Metadata

Authors
Austin, M. A., & Edwards, K. L.
Affiliations
University of Washington (US)
ORCID
Venue
Current Opinion in Lipidology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1996-06
Volume
7
Issue
3
Pages
167-171
ISSN
0957-9672 (ISSN-L)
DOI
10.1097/00041433-199606000-00010
OpenAlex
W1974432134
Cited by
126
References
0
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
6.42
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Lipidology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl046880-04, 2r01hl049513-08)
  • National Heart, Lung, and Blood Institute (R-01 HL49513, R-01 HL-46880)
  • National Cancer Institute (R01CA149051)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords
small dense LDL, metabolic syndrome, type 2 diabetes, coronary heart disease risk, atherogenic lipoproteins, factor analysis, risk factor clustering, dyslipidemia
MeSH terms
Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Lipoproteins, LDL, Phenotype, Risk Factors, Multivariate Analysis

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