The DOI matches its Crossref record.
Small, dense low density lipoproteins, the insulin resistance syndrome and noninsulin-dependent diabetes
Abstract
The role of small, dense LDL as a risk factor for coronary heart disease is becoming well established. Several atherogenic mechanisms have been proposed to explain this relationship, including the association of small, dense LDL with the insulin resistance syndrome. A variety of studies, including large epidemiologic investigations, have now demonstrated that a predominance of small, dense LDL is one of the constellation of interrelated risk factors that characterize the insulin resistance syndrome. Recent results using a multivariate factor analysis approach have also shown that this set of risk factors can be simplified into three or four uncorrelated components that may provide new insights into the mechanisms underlying the syndrome and its association with disease. Furthermore, a number of cross-sectional studies and one prospective study have shown that small, dense LDL is a risk factor for noninsulin-dependent diabetes itself, and that this association may also be attributable to the insulin resistance syndrome.
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In the citing paper
“Small dense LDL is closely associated with hypertriglyceridemia and hypo-HDL cholesterolemia259, 266).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [266]
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Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R. (1999) · Circulation · doi:10.1161/01.cir.100.10.1134 · Cited by 2,698
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813
Hypertriglyceridemia, insulin resistance, and the metabolic syndrome
Grundy, S. M. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00211-8 · Cited by 610
Li-ya, W., & Parhofer, K. G. (2014) · Metabolism · doi:10.1016/j.metabol.2014.08.010 · Cited by 543
Shih, D. Q., Bussen, M., Sehayek, E., Ananthanarayanan, M., Shneider, B. L., Suchy, F. J., Shefer, S., Bollileni, J. S., Gonzalez, F. J., Breslow, J. L., et al. (2001) · Nature Genetics · doi:10.1038/86871 · Cited by 422
“Small dense LDL is a spherical particle that contains mainly esterified cholestero”
Background
Metadata
- Authors
- Austin, M. A., & Edwards, K. L.
- Affiliations
- University of Washington (US)
- Venue
- Current Opinion in Lipidology
- Published
- 1996-06
- Volume
- 7
- Issue
- 3
- Pages
- 167-171
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W1974432134
- Cited by
- 126
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl046880-04, 2r01hl049513-08)
- National Heart, Lung, and Blood Institute (R-01 HL49513, R-01 HL-46880)
- National Cancer Institute (R01CA149051)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- small dense LDL, metabolic syndrome, type 2 diabetes, coronary heart disease risk, atherogenic lipoproteins, factor analysis, risk factor clustering, dyslipidemia
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Lipoproteins, LDL, Phenotype, Risk Factors, Multivariate Analysis
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