Gene variants, insulin resistance, and dyslipidaemia

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamäki, J., Mykkänen, L., Kuusisto, J., Laakso, M., Fujimoto, W., & Auwerx, J. (1998) · Nature Genetics · doi:10.1038/3099 · Cited by 1,319

IRS proteins and the common path to diabetes

White, M. F. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2001 · Cited by 925

Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors

Lee, C., Olson, P., & Evans, R. M. (2003) · Endocrinology · doi:10.1210/en.2003-0288 · Cited by 891

Guilt by association

Altshuler, D., Daly, M. J., & Kruglyak, L. (2000) · Nature Genetics · doi:10.1038/79839 · Cited by 764

The Metabolic Syndrome

Reilly, M. P., & Rader, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000088846.10655.e0 · Cited by 466

Epidemic Obesity and the Metabolic Syndrome

Haffner, S. M., & Taegtmeyer, H. (2003) · Circulation · doi:10.1161/01.cir.0000088845.17586.ec · Cited by 425

An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

Baier, L. J., Sacchettini, J. C., Knowler, W. C., Eads, J. C., Paolisso, G., Tataranni, P. A., Mochizuki, H., Bennett, P. H., Bogardus, C., & Procházka, M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117778 · Cited by 371

Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Nondiabetic Men

Lempiäinen, P., Mykkänen, L., Pyörälä, K., Laakso, M., & Kuusisto, J. (1999) · Circulation · doi:10.1161/01.cir.100.2.123 · Cited by 293

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961

A clinical perspective of obesity, metabolic syndrome and cardiovascular disease

Han, T. S., & Lean, M. E. (2016) · JRSM Cardiovascular Disease · doi:10.1177/2048004016633371 · Cited by 500

Diagnosis and management of the metabolic syndrome

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000200416.65370.a0 · Cited by 437

n−3 Fatty acids and the metabolic syndrome

Carpentier, Y., Portois, L., & Malaisse, W. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1499s · Cited by 286

Nuclear Magnetic Resonance Lipoprotein Abnormalities in Prediabetic Subjects in the Insulin Resistance Atherosclerosis Study

Festa, A., Williams, K., Hanley, A. J., Otvos, J. D., Goff, D. C., Wagenknecht, L. E., & Haffner, S. M. (2005) · Circulation · doi:10.1161/circulationaha.104.512079 · Cited by 260

Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches

Mohamed, S. M., Shalaby, M. A., El‐Shiekh, R. A., El-Banna, H. A., Emam, S. R., & Bakr, A. F. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2023.100335 · Cited by 288

The Type 2 Deiodinase A/G (Thr92Ala) Polymorphism Is Associated with Decreased Enzyme Velocity and Increased Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Canani, L. H. S., Capp, C., Dora, J. M., Meyer, E. L. D. S., Wagner, M. S., Harney, J. W., Larsen, P. R., Gross, J. L., Bianco, A. C., & Maia, A. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1977 · Cited by 205

Metabolic syndrome and cardiovascular risk

Alshehri, A. (2010) · Journal of Family and Community Medicine · doi:10.4103/1319-1683.71987 · Cited by 184

Genetic and epigenetic control of metabolic health

Schwenk, R. W., Vogel, H., & Schürmann, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.002 · Cited by 135

New targets to treat obesity and the metabolic syndrome

Martin, K. A., Mani, M. V., & Mani, A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.093 · Cited by 121

Antioxidants: do they have a role in the treatment of insulin resistance?

Evans, J. L. (2007) · PubMed · Cited by 99

The Key Role of Insulin Resistance in the Cardiometabolic Syndrome

Gill, H., Mugo, M. N., Whaley‐Connell, A. T., Stump, C. S., & Sowers, J. R. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00006 · Cited by 80

Insulin resistance and hepatitis C: an evolving story

Eslam, M., Khattab, M. A., & Harrison, S. A. (2011) · Gut · doi:10.1136/gut.2010.228262 · Cited by 74

The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface

Heikkinen, S., Argmann, C., Feige, J. N., Koutníková, H., Champy, M., Dali‐Youcef, N., Schadt, E. E., Laakso, M., & Auwerx, J. H. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.007 · Cited by 72

Novel Approach to Treat Insulin Resistance, Type 2 Diabetes, and the Metabolic Syndrome: Simultaneous Activation of PPARα, PPARγ, and PPARδ

Evans, J. L., Lin, J., & Goldfine, I. D. (2005) · Current Diabetes Reviews · doi:10.2174/157339905774574365 · Cited by 56

Application of nutrigenomic concepts to Type 2 diabetes mellitus

Kaput, J., Noble, J. A., Hatipoğlu, B., Kari Kohrs, E., Dawson, K., & Bartholomew, A. M. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.11.006 · Cited by 57

Anti-obesity effects of dichloromethane leaf extract of Gnidia glauca in high fat diet-induced obese rats

Arika, W. M., Kibiti, C. M., Njagi, J. M., & Ngugi, M. P. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02800 · Cited by 42

Dietary fat, genes and insulin sensitivity

López‐Miranda, J., Pérez‐Martínez, P., Marín, C., Fuentes, F. J., Delgado‐Lista, J., & Pérez‐Jiménez, F. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0138-1 · Cited by 37

Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: A case for dimensionality reduction?

Kaput, J., & Dawson, K. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.02.033 · Cited by 31

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Žák, A., TVRZICKÁ, E., Vecka, M., Jáchymová, M., Duffková, L., Staňková, B., Vávřová, L., Kodydková, J., & Zeman, M. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.212.359 · Cited by 30

Early Life Origins of Obesity

Newnham, J. P., Pennell, C. E., Lye, S. J., Rampono, J., & Challis, J. R. G. (2009) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2009.03.004 · Cited by 30

Effective treatments for insulin resistance: trim the fat and douse the fire

Evans, J. L., YOUNGREN, J. F., & Goldfine, I. D. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.09.005 · Cited by 29

The influence of polymorphism of −493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress

Žák, A., Jáchymová, M., TVRZICKÁ, E., Vecka, M., Duffková, L., Zeman, M., Slaby, A., & Staňková, B. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.09.001 · Cited by 23

Insulin resistance and lipid disorders

Miccoli, R., Keyzer, D. D., Penno, D. G., & Prato, D. S. D. (2008) · Future Lipidology · doi:10.2217/17460875.3.6.651 · Cited by 24

The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy

Knight, B. S., Pennell, C. E., Adamson, S. L., & Lye, S. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.126573 · Cited by 23

Strain Differences in the Impact of Dietary Restriction on Fetal Growth and Pregnancy in Mice

Knight, B. S., Pennell, C. E., Shah, R., & Lye, S. J. (2007) · Reproductive Sciences · doi:10.1177/1933719106298217 · Cited by 20

Metabolic syndrome and vascular risk in patients with peripheral arterial occlusive disease

Vlek, A. L. M., van der Graaf, Y., Sluman, M. A., Moll, F. L., & Visseren, F. L. J. (2009) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2008.12.070 · Cited by 19

Polymorphic markers associated with genes responsible for lipid and carbohydrate metabolism disorders and insulin resistance in cancer patients

Улыбина, Ю. М., Имянитов, Е. Н., Vasilyev, D. A., & Berstein, L. M. (2008) · Molecular Biology · doi:10.1134/s0026893308060034 · Cited by 7

Alcohol and Dyslipidemia

Chowdhury, I. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-047-2_26 · Cited by 6

Approaches to Evaluate Gene-Environment Interactions Underlying the Developmental Origins of Health and Disease

Pennell, C. E., Palmer, L. J., Knight, B. S., Relton, C. L., & Lye, S. J. (2009) · KARGER eBooks · doi:10.1159/000221166 · Cited by 6

Suplementos nutricionales como modificadores del riesgo cardiovascular en componentes del síndrome metabólico en adultos

Tassinari, S., Azuero, A. J., Arreaza-Kaufman, D., Rueda, M. C., Castañeda‐Cardona, C., & Rosselli, D. (2016) · Revista Colombiana de Cardiología · doi:10.1016/j.rccar.2016.09.013 · Cited by 2

Pathogenesis of the Metabolic Syndrome

Tobe, K., Yamauchi, T., Kubota, N., Hara, K., Ueki, K., & Kadowaki, T. (2007) · Springer eBooks · doi:10.1007/978-1-84628-911-8_3 · Cited by 2

Analysis of interactions of lipid metabolism alleles in dyslipidemia

Nikolaev, I. V., Mulyukova, R. V., Раилевна, К. Л., Vorobieva, E. V., & Gorbunova, V. Y. (2015) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059715040103 · Cited by 1

Intracellular Fatty Acid Binding Proteins in Metabolic Regulation

Stewart, J. M. (2006) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.200400116 · Cited by 1

Promoter variants and variant promoters of the hepatic lipase gene

Botma, G. J. (2006) · EUR Research Repository (Erasmus University Rotterdam)

Association/National Heart, Lung, and Blood Institute Scientific Statement Diagnosis and Management of the Metabolic Syndrome: An American Heart

Smith, C. S., Spertus, J. A., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Grundy, S. M., Cleeman, J. I., Daniels, S. R., & Donato, K. A. (2006)

Gene-environment Interactions Underlying the Developmental Origins of Health and Disease

Knight, B. S. (2008) · TSpace (University of Toronto)

Analysis of genetic aspects of therapy with Rosuvastatin

Kozhakhmetov, S., Kushugulova, A. R., Kakimova, A. B., Nurgozhin, T. S., & Zhumadilov, Z. S. (2016) · Journal of Clinical Medicine of Kazakhstan · doi:10.23950/1812-2892-2016-2-22-26

Anti-Obesity, Cognitive Enhancing, Neurobehavioral, Antioxidant Effects And Phytochemical Profile Of Dichloromethane Leaf Extract Of Gnidia Glauca (Fresen)

Makori, W. A. (2019)

Lipid-gene interactions, diet and health

Lairon, D., & Planells, R. (2006) · Elsevier eBooks · doi:10.1533/9781845691073.1.49

Le petit déjeuner standardisé. Un outil diagnostique du statut glycémique et des modifications cardiovasculaires postprandiales ? : Comparaison vs la charge en glucose ; et explorations cardiovasculaires sous saxagliptine vs placebo chez des patients intolérants au glucose

Rezki, A. (2019) · theses.fr (ABES) · doi:10.70675/392902d9z7810z4025zb9afz3081c32bac5d

Orígenes de la obesidad en edades tempranas

Newnham, J. P., Pennell, C. E., Lye, S. J., Rampono, J., & Challis, J. R. G. (2009) · Clínicas obstétricas y ginecológicas de Norteamérica

Dietary fat, genes and insulin sensitivity

López‐Miranda, J., Pérez‐Martínez, P., Marín, C., Fuentes, F. J., Delgado‐Lista, J., & Pérez‐Jiménez, F. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0138-1 · Cited by 37

Liver Fat and Insulin Resistance Are Independently Associated with the −514C>T Polymorphism of the Hepatic Lipase Gene

Stefan, N., Schäfer, S., Machicao, F. E., Machann, J., Schick, F., Claussen, C. D., Stümvoll, M., Häring, H., & Fritsche, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2479 · Cited by 32

Differential effects of the C1431T and Pro12Ala PPARγ gene variants on plasma lipids and diabetes risk in an Asian population

Tai, E. S., Corella, D., Deurenberg‐Yap, M., Adiconis, X., Chew, S. K., Tan, C. E., & Ordovás, J. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300363-jlr200 · Cited by 120

Effects of lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene variants on metabolic syndrome traits [Utjecaj polimorfizama gena za lipoprotein lipazu i receptora za aktivator proliferacije peroksisoma-gama na sastavnice metaboličkog sindroma]

Božina, T., Šimić, I., Lovrić, J., Pećin, I., Jelaković, B., Sertić, J., & Reiner, Ž. (2013) · Dr Med - University of Zagreb School of Medicine Digital Repository

Effects of Lipoprotein Lipase and Peroxisome Proliferator-Activated Receptor-g Gene Variants on Metabolic Syndrome Traits

Božina, T., Šimić, I., Lovrić, J., Pećin, I., Jelaković, B., Sertić, J., & Reiner, Ž. (2013) · Hrčak Portal of scientific journals of Croatia (University Computing Centre) · Cited by 1