Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Nondiabetic Men
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Background —The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. Methods and Results —Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (factors) predict CHD events (CHD death or nonfatal myocardial infarction) in a nondiabetic population of 1069 subjects 65 to 74 years old from eastern Finland followed up for 7 years. There were 151 CHD events (92 for men, 59 for women) during the follow-up period. In men, factor 1 (the insulin resistance factor, which reflected primarily body mass index, waist-to-hip ratio, triglycerides, fasting plasma glucose, and insulin) (hazards ratio [HR] with 95% CI, 1.33, CI 1.08, 1.65, P =0.008), factor 2 (alcohol consumption, high HDL cholesterol, low triglycerides) (HR 0.78, CI 0.63, 0.96, P =0.020), factor 3 (age, systolic blood pressure, urinary albumin/creatinine ratio, left ventricular hypertrophy) (HR 1.52, CI 1.26, 1.83, P <0.001), and factor 4 (high total cholesterol and triglycerides) (HR 1.42, CI 1.15, 1.77, P =0.002) predicted CHD events in multivariate Cox regression analysis. In women, the insulin resistance factor did not predict CHD events (HR 1.06, CI 0.82, 1.36), but factor 2 (previous stroke, low HDL cholesterol and high triglycerides) (HR 1.34, CI 1.06, 1.69, P =0.014) and factor 3 (age, systolic blood pressure, urinary albumin/creatinine ratio, left ventricular hypertrophy) (HR 1.44, CI 1.15, 1.82, P =0.002) predicted CHD events. Conclusions —Our study supports the notion that the insulin resistance syndrome is a risk factor for CHD in elderly men.
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The MS has been associated with incident CHD and CHD mortality.
“The MS has been associated with incident CHD and CHD mortality, [5][6][7][8][9][10][11]”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [5]
Both overt diabetes and the metabolic syndrome are associated with increased risk of cardiovascular events and death.
“Both overt diabetes 3,4 and the MS [5][6][7][8][9][10][11] are associated with increased risk of cardiovascular events and death.”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [5]
Many studies evaluating the MS and clinical cardiovascular outcomes included only men or noted a relative paucity of events among women compared with men.
“Many of the studies evaluating the MS and clinical cardiovascular outcomes have included only men 5,6,8,9 or have noted a relative paucity of events among women compared with men.11,39,40”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [5]
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- Authors
- Lempiäinen, P., Mykkänen, L., Pyörälä, K., Laakso, M., & Kuusisto, J.
- Affiliations
- From the Department of Medicine, University of Kuopio, Finland (P.L., L.M., K.P., M.L., J.K.), and the University of Texas Health Science Center at San Antonio (L.M.).
- The University of Texas at San Antonio Health Science Center (US)
- ORCID
- Laakso, Markku
- Venue
- Circulation
- Published
- 1999-07-13
- Volume
- 100
- Issue
- 2
- Pages
- 123-128
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2136394776
- Cited by
- 293
- References
- 37
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 1 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 21 · 2012: 9
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suomen Kulttuurirahasto
- Aarne ja Aili Turusen Säätiö
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- metabolic syndrome, coronary artery disease, cardiovascular risk factors, risk factor clustering, myocardial infarction, cardiovascular mortality, older men, alcohol consumption, HDL cholesterol, triglycerides, left ventricular hypertrophy, urinary albumin-creatinine ratio, systolic blood pressure, body mass index, waist-to-hip ratio, sex differences
- MeSH terms
- Aged, Aging, Coronary Disease, Factor Analysis, Statistical, Female, Forecasting, Humans, Insulin Resistance, Male, Myocardial Infarction, Risk Factors, Syndrome, Multivariate Analysis
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