Mechanism of lipoprotein retention by the extracellular matrix

Gustafsson, Maria; Borén, Jan

doi:10.1097/00041433-200410000-00003

Cited by 75Proteoglycans and glycosaminoglycans researchCholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Mechanism of lipoprotein retention by the extracellular matrix

Gustafsson, Maria, Borén, Jan·2004·Current Opinion in Lipidology

DOI 10.1097/00041433-200410000-00003

Open this paper in CoChat — free account

Abstract

PURPOSE OF REVIEW: Considerable evidence suggests that the subendothelial retention of atherogenic lipoproteins is a key early step in atherogenesis. In humans and experimental animals, elevated levels of plasma lipoproteins are associated with increased atherosclerosis, and lipoproteins with higher affinity for arterial proteoglycans are more atherogenic. Here we discuss the molecular mechanisms underlying lipoprotein retention in the arterial wall and how this interaction can be modulated. RECENT FINDINGS: Functional proteoglycan binding sites in lipoproteins containing apolipoprotein B have been identified and shown to have atherogenic potential in vivo. In addition to apolipoprotein B, novel bridging molecules, those that can interact with both proteoglycans and lipoproteins, have been identified that mediate the retention of atherogenic particles in the vessel wall. The interaction between lipoproteins and proteoglycans can be enhanced by the modification of lipoproteins in the circulation and in the arterial wall, by alterations in the subendothelium, and by changes in proteoglycan synthesis that result in a more atherogenic profile. The retention of atherogenic lipoproteins is a potential target for therapies to reverse atherosclerosis, and in-vitro studies have identified compounds that decrease the affinity of proteoglycans for lipoproteins. SUMMARY: Considerable progress has been made in understanding the association between lipoproteins and cardiovascular disease. This review highlights the importance of the interaction between lipoproteins and the arterial matrix.

Integrity signals

Registry

Crossref · 10.1097/00041433-200410000-00003

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Retention of lipoproteins in the arterial extracellular matrix is a critical step in atherogenesis in which lipoproteins with higher affinity for arterial proteoglycans are more atherogenic.
“The retention of lipoproteins in the arterial extracellular matrix is a critical step in atherogenesis in which lipoproteins with higher affinity for arterial proteoglycans are more atherogenic (55, 56).”
From Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study (2008) · cites this paper as [56]

Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
Atherosclerosis
Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,049 · see citing works
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,121 · see citing works
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413 · see citing works
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019 · see citing works
Self-citation
A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
Stary, H. C., Blankenhorn, D. H., Chandler, A. B., Glagov, S. K., Insull, W., Richardson, M., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., & Wagner, W. D. (1992) · Circulation · doi:10.1161/01.cir.85.1.391 · Cited by 624 · see citing works
Complete protein sequence and identification of structural domains of human apolipoprotein B
Knott, T. J., Pease, R. J., Powell, L. M., Wallis, S. C., Rall, S. C., Innerarity, T. L., Blackhart, B. D., Taylor, W. H., Marcel, Y. L., Milne, R. W., et al. (1986) · Nature · doi:10.1038/323734a0 · Cited by 619 · see citing works
The Interaction between Human Plasma Lipoproteins and Connective Tissue Glycosaminoglycans
Iverius, P. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45469-0 · Cited by 464 · see citing works
Response to injury and atherogenesis.
Ross, R., Glomset, J., & Harker, L. A. (1977) · PubMed · Cited by 458 · see citing works
Advanced Atherosclerotic Lesions in the Innominate Artery of the ApoE Knockout Mouse
Rosenfeld, M. E., Polinsky, P., Virmani, R., Kauser, K. Z., Rubanyi, G. M., & Schwartz, S. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.2587 · Cited by 384 · see citing works
Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL vs. selective increases in LDL permeability in susceptible sites of arteries.
Schwenke, D. C., & Carew, T. E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.6.908 · Cited by 344 · see citing works
Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.
Schönherr, E., Järveläinen, H., Sandell, L. J., & Wight, T. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47419-x · Cited by 334 · see citing works
Selective Retention of VLDL, IDL, and LDL in the Arterial Intima of Genetically Hyperlipidemic Rabbits In Vivo: Molecular Size as a Determinant of Fractional Loss From the Intima–Inner Media
Nordestgaard, B. G., Wootton, R., & Lewis, B. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.4.534 · Cited by 334 · see citing works
Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding.
Borén, J., Olin, K., Lee, I., Chait, A., Wight, T. N., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2265 · Cited by 320 · see citing works
Self-citation
Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions.
Schwenke, D. C., & Carew, T. E. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.6.895 · Cited by 272 · see citing works
Comparison of Apolipoprotein and Proteoglycan Deposits in Human Coronary Atherosclerotic Plaques
O’Brien, K. D., Olin, K. L., Alpers, C. E., Chiu, W. S., Ferguson, M. S., Hudkins, K. L., Wight, T. N., & Chait, A. (1998) · Circulation · doi:10.1161/01.cir.98.6.519 · Cited by 271 · see citing works
Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions
Öörni, K., Pentikäinen, M. O., Ala-Korpela, M., & Kovanen, P. T. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31964-7 · Cited by 252 · see citing works
Circulating Levels of Secretory Type II Phospholipase A 2 Predict Coronary Events in Patients with Coronary Artery Disease
Kugiyama, K., Ota, Y., Takazoe, K., et al. (1999) · Circulation · doi:10.1161/01.cir.100.12.1280 · Cited by 249 · see citing works
Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans
Anber, V., Griffin, B. A., McConnell, M., Packard, C. J., & Shepherd, J. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05842-x · Cited by 237 · see citing works
Accumulation of lipoprotein fractions and subfractions in the arterial wall, determined in an in vitro perfusion system
Björnheden, T., Babyi, A., Bondjers, G., & Wiklund, O. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05770-6 · Cited by 230 · see citing works
The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
Santamarina-Fojo, S., Haudenschild, C., & Amar, M. J. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199806000-00005 · Cited by 229 · see citing works
Arterial retention of apolipoprotein B48- and B100-containing lipoproteins in atherogenesis
Proctor, S. D., Vine, D. F., & Mamo, J. C. L. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200210000-00001 · Cited by 200 · see citing works
Identification of Apo B-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans.
Camejo, G., Olofsson, S. ‐., Lopez, F., Carlsson, P., & Bondjers, G. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.4.368 · Cited by 198 · see citing works
Human apolipoprotein B-100 heparin-binding sites.
Weisgraber, K. H., & Rall, S. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60931-7 · Cited by 193 · see citing works
The glycosaminoglycans of the human artery and their changes in atherosclerosis.
Stevens, R. L., Colombo, M., Gonzales, J., et al. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108491 · Cited by 188 · see citing works
Mechanical Strain Induces Specific Changes in the Synthesis and Organization of Proteoglycans by Vascular Smooth Muscle Cells
Lee, R. T., Yamamoto, C., Feng, Y., Potter‐Perigo, S., Briggs, W. H., Landschulz, K. T., Turi, T. G., Thompson, J. F., Libby, P., & Wight, T. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010556200 · Cited by 184 · see citing works
Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells.
Hurt‐Camejo, E., Camejo, G., Rosengren, B. E., López, F., Ahlström, C., Fager, G., & Bondjers, G. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.5.569 · Cited by 184 · see citing works
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
Willner, E. L., Tow, B., Buhman, K. K., Wilson, M. D., Sanan, D. A., Rudel, L. L., & Farese, R. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336398100 · Cited by 181 · see citing works
Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.
Grass, D., Felkner, R. H., Chiang, M. Y., Wallace, R., Nevalainen, T. J., Bennett, C. F., & Swanson, M. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118664 · Cited by 171 · see citing works
Platelet-derived growth factor and transforming growth factor-beta 1 differentially affect the synthesis of biglycan and decorin by monkey arterial smooth muscle cells.
Schönherr, E., Järveläinen, H., Kinsella, M. G., et al. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.7.1026 · Cited by 166 · see citing works
Cellular Consequences of the Association of ApoB Lipoproteins With Proteoglycans
Hurt‐Camejo, E., Olsson, U., Wiklund, O., Bondjers, G., & Camejo, G. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.6.1011 · Cited by 165 · see citing works
Increase in Serum Amyloid A Evoked by Dietary Cholesterol Is Associated With Increased Atherosclerosis in Mice
Lewis, K. E., Kirk, E. A., McDonald, T. O., Wang, S., Wight, T. N., O’Brien, K. D., & Chait, A. (2004) · Circulation · doi:10.1161/01.cir.0000136819.93989.e1 · Cited by 163 · see citing works
Proteoglycans Synthesized by Arterial Smooth Muscle Cells in the Presence of Transforming Growth Factor-β1 Exhibit Increased Binding to LDLs
Little, P. J., Tannock, L. R., Olin, K. L., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101100 · Cited by 159 · see citing works
Role of Group II Secretory Phospholipase A 2 in Atherosclerosis
Leitinger, N., Watson, A. D., Hama, S. Y., Ivandic, B., Qiao, J.-H., Huber, J., Faull, K. F., Grass, D., Navab, M., Fogelman, A. M., et al. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.5.1291 · Cited by 151 · see citing works
Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: Direct evidence that lipoprotein lipase bridging occurs in vivo
Merkel, M., Kako, Y., Radner, H., Cho, I. S., Ramasamy, R., Brunzell, J. D., Goldberg, I. J., & Breslow, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13841 · Cited by 150 · see citing works
Interaction of low density lipoproteins with arterial proteoglycans The role of charge and sialic acid content
Camejo, G., López, A., López, F., & Quiñones, J. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90169-8 · Cited by 138 · see citing works
Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic Lesions
Hakala, J. K., Oksjoki, R. K., Laine, P., Du, H., Grabowski, G. A., Kovanen, P. T., & Pentikäinen, M. O. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000077207.49221.06 · Cited by 138 · see citing works
Biosynthesis of Apolipoprotein B48-containing Lipoproteins
Innerarity, T. L., Borén, J., Yamanaka, S., & Olofsson, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2353 · Cited by 130 · see citing works
Self-citation
Interaction of serum lipoproteins and a proteoglycan from bovine aorta.
Vijayagopal, P., Srinivasan, S. R., Radhakrishnamurthy, B., et al. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43414-x · Cited by 129 · see citing works
Lipoprotein Lipase: Some Effects of Activator Proteins
Bengtsson, G., & Olivecrona, T. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04602.x · Cited by 127 · see citing works
Molecular Mechanism for Changes in Proteoglycan Binding on Compositional Changes of the Core and the Surface of Low-Density Lipoprotein–Containing Human Apolipoprotein B100
Flood, C., Gustafsson, M. V., Pitas, R. E., Arnaboldi, L., Walzem, R. L., & Borén, J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000117174.19078.85 · Cited by 125 · see citing works
Self-citation
Intimal Retention of Cholesterol Derived From Apolipoprotein B100– and Apolipoprotein B48–Containing Lipoproteins in Carotid Arteries of Watanabe Heritable Hyperlipidemic Rabbits
Proctor, S. D., & Mamo, J. C. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000084638.14534.0a · Cited by 124 · see citing works
Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men
Holl, L. G., Krauss, R. M., Williams, P. T., Superko, H. R., Haskell, W. L., Alderman, E. L., Patricia, J., & Blanche, P. J. (2015) · Cited by 122 · see citing works
Ultrastructure of Early Lipid Accumulation in ApoE-Deficient Mice
Tamminen, M., Mottino, G. A., Qiao, J. H., Breslow, J. L., & Frank, J. S. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.847 · Cited by 122 · see citing works
Phospholipase A2 Modification of Low Density Lipoproteins Forms Small High Density Particles with Increased Affinity for Proteoglycans and Glycosaminoglycans
Sartipy, P., Camejo, G., Svensson, L., & Hurt‐Camejo, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25913 · Cited by 118 · see citing works
Interaction of Very-Low-Density, Intermediate-Density, and Low-Density Lipoproteins With Human Arterial Wall Proteoglycans
Anber, V., Millar, J. S., McConnell, M., Shepherd, J., & Packard, C. J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2507 · Cited by 117 · see citing works
Endogenously Produced Endothelial Lipase Enhances Binding and Cellular Processing of Plasma Lipoproteins via Heparan Sulfate Proteoglycan-mediated Pathway
Fuki, I. V., Blanchard, N., Jin, W., Marchadier, D. H. L., Millar, J. S., Glick, J. M., & Rader, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302181200 · Cited by 115 · see citing works
Atherogenecity of lipoprotein(a) and oxidized low density lipoprotein: insight from in vivo studies of arterial wall influx, degradation and efflux
Nielsen, L. B. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00064-7 · Cited by 115 · see citing works
ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan
Olin-Lewis, K., Krauss, R. M., La Belle, M., Blanche, P. J., Barrett, P. H. R., Wight, T. N., & Chait, A. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200322-jlr200 · Cited by 114 · see citing works
Lipolysis of LDL by Human Secretory Phospholipase A 2 Induces Particle Fusion and Enhances the Retention of LDL to Human Aortic Proteoglycans
Hakala, J. K., Öörni, K., Pentikäinen, M. O., Hurt‐Camejo, E., & Kovanen, P. T. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.1053 · Cited by 111 · see citing works
Lipoprotein Lipase in the Arterial Wall
Pentikäinen, M. O., Oksjoki, R. K., Öörni, K., & Kovanen, P. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101551 · Cited by 108 · see citing works
Distribution of glycosaminoglycans in the intima of human aortas: changes in atherosclerosis and diabetes mellitus
Wasty, F., ALAVI, M. Z., & Moore, S. (1993) · Diabetologia · doi:10.1007/bf00400234 · Cited by 107 · see citing works
Identification of the Proteoglycan Binding Site in Apolipoprotein B48
Flood, C., Gustafsson, M. V., Richardson, P. E., Harvey, S. C., Segrest, J. P., & Borén, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204053200 · Cited by 107 · see citing works
Self-citation
Group V sPLA 2 Hydrolysis of Low-Density Lipoprotein Results in Spontaneous Particle Aggregation and Promotes Macrophage Foam Cell Formation
Wooton‐Kee, C. R., Boyanovsky, B. B., Nasser, M. S., de Villiers, W. J. S., & Webb, N. R. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000122363.02961.c1 · Cited by 103 · see citing works
Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Véniant, M. M., Pierotti, V, Newland, D., Cham, C. M., Sanan, D. A., Walzem, R. L., & Young, S. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119511 · Cited by 100 · see citing works
Lipoprotein Lipase Enhances the Binding of Native and Oxidized Low Density Lipoproteins to Versican and Biglycan Synthesized by Cultured Arterial Smooth Muscle Cells
Olin, K. L., Potter‐Perigo, S., Barrett, P. H. R., Wight, T. N., & Chait, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34629 · Cited by 99 · see citing works
Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins.
Olsson, U., Bondjers, G., & Camejo, G. (1999) · Diabetes · doi:10.2337/diabetes.48.3.616 · Cited by 97 · see citing works
Oxidized Low Density Lipoproteins Regulate Synthesis of Monkey Aortic Smooth Muscle Cell Proteoglycans That Have Enhanced Native Low Density Lipoprotein Binding Properties
Chang, M. Y., Potter‐Perigo, S., Tsoi, C., Chait, A., & Wight, T. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4766 · Cited by 95 · see citing works
Distal Protection With a Filter Device During Coronary Stenting in Patients With Stable and Unstable Angina
Angelini, A., Rubartelli, P., Mistrorigo, F., et al. (2004) · Circulation · doi:10.1161/01.cir.0000137821.94074.ee · Cited by 95 · see citing works
Immunoelectron microscopy of low density lipoproteins yields a ribbon and bow model for the conformation of apolipoprotein B on the lipoprotein surface.
Chatterton, J. E., Phillips, M. L., Curtiss, L. K., et al. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41120-4 · Cited by 94 · see citing works
Isolation and characterization of four heparin-binding cyanogen bromide peptides of human plasma apolipoprotein B
Hirose, N., Blankenship, D. T., Krivanek, Jackson, R. L., & Cardin, A. D. (1987) · Biochemistry · doi:10.1021/bi00391a044 · Cited by 92 · see citing works
Cell-Associated and Extracellular Phospholipid Transfer Protein in Human Coronary Atherosclerosis
O’Brien, K. D., Vuletic, S., McDonald, T. O., Wolfbauer, G., Lewis, K., Tu, A.-Y., Marcovina, S. M., Wight, T. N., Chait, A., & Albers, J. J. (2003) · Circulation · doi:10.1161/01.cir.0000079163.97653.cd · Cited by 83 · see citing works
Proatherosclerotic events: pathobiochemical changes occurring in the arterial wall before monocyte migration
Simionescu, M., & Simionescu, N. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.14.8224609 · Cited by 77 · see citing works
Decorin Links Low-Density Lipoproteins (LDL) to Collagen A Novel Mechanism for Retention of LDL in the Atherosclerotic Plaque
Kovanen, P. T. (1999) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(99)00013-4 · Cited by 67 · see citing works
The extracellular matrix on atherogenesis and diabetes-associated vascular disease
Camejo, G., Olsson, U., Hurt‐Camejo, E., Baharamian, N., & Bondjers, G. (2002) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(01)00005-8 · Cited by 63 · see citing works
The participation of aortic proteins in the formation of complexes between low density lipoproteins and intima-media extracts
Camejo, G., López, A., Vegas, H., et al. (1975) · Atherosclerosis · doi:10.1016/0021-9150(75)90095-7 · Cited by 63 · see citing works
Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells
Nigro, J., Dilley, R. J., & Little, P. J. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00704-3 · Cited by 61 · see citing works
Binding of recombinant apolipoprotein(a) to extracellular matrix proteins.
van der Hoek, Y. Y., Sangrar, W., Côté, G. P., et al. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.11.1792 · Cited by 58 · see citing works
The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis.
Higazi, A. A., Nassar, T., Ganz, T., Rader, D. J., Udassin, R., Bdeir, K. H., Hiss, E., Sachais, B. S., Williams, K. J., Leitersdorf, E., et al. (2000) · PubMed · doi:10.1182/blood.v96.4.1393 · Cited by 57 · see citing works
Phospholipase A 2 Type II Binds to Extracellular Matrix Biglycan
Sartipy, P., Bondjers, G., & Hurt‐Camejo, E. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.12.1934 · Cited by 56 · see citing works
Effects of Nonlipolytic Ligand Function of Endothelial Lipase on High Density Lipoprotein Metabolism in Vivo
Broedl, U. C., Maugeais, C., Marchadier, D. H. L., Glick, J. M., & Rader, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304367200 · Cited by 55 · see citing works
The NH2-terminal Region of Apolipoprotein B Is Sufficient for Lipoprotein Association with Glycosaminoglycans
Goldberg, I. J., Wagner, W. D., Pang, L., Paka, L., Curtiss, L. K., DeLozier, J. A., Shelness, G. S., Young, C. S. H., & Pillarisetti, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35355 · Cited by 55 · see citing works
Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries
Azumi, H. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00287-6 · Cited by 55 · see citing works
Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6-sulfate
Camejo, G., Hurt‐Camejo, E., Wiklund, O., Rosengren, B. E., López, F., & Bondjers, G. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(91)90013-y · Cited by 53 · see citing works
Proteoglycans Contribution to Association of Lp(a) and LDL With Smooth Muscle Cell Extracellular Matrix
Lundstam, U., Hurt‐Camejo, E., Olsson, G., Sartipy, P., Camejo, G., & Wiklund, O. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.5.1162 · Cited by 51 · see citing works
Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL
Tannock, L. R., Little, P. J., Wight, T. N., et al. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30198-x · Cited by 47 · see citing works
Normal and Oxidized Low Density Lipoproteins Accumulate Deep in Physiologically Thickened Intima of Human Coronary Arteries
Fukuchi, M., Watanabe, J., Kumagai, K., et al. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000032546.01658.5d · Cited by 42 · see citing works
Lipoprotein-proteoglycan complexes from injured rabbit aortas accelerate lipoprotein uptake by arterial smooth muscle cells
Ismail, N. A. E., ALAVI, M. Z., & Moore, S. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90010-8 · Cited by 40 · see citing works
The Heparin-Binding Proteins Apolipoprotein E and Lipoprotein Lipase Enhance Cellular Proteoglycan Production
Obunike, J. C., Pillarisetti, S., Paka, L., Kako, Y., Butteri, M. J., Ho, Y.-Y., Wagner, W. D., Yamada, N., Mazzone, T., Deckelbaum, R. J., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.1.111 · Cited by 38 · see citing works
Lysophosphatidylcholine Regulates Synthesis of Biglycan and the Proteoglycan Form of Macrophage Colony Stimulating Factor
Chang, M. Y., Tsoi, C., Wight, T. N., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000069208.20268.d0 · Cited by 35 · see citing works
Apolipoprotein A-I Regulates Lipid Hydrolysis by Hepatic Lipase
Ramsamy, T. A., Neville, T. A.-M., Chauhan, B. M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005436200 · Cited by 32 · see citing works
Marked low‐density lipoprotein cholesterol reduction below current national cholesterol education program targets provides the greatest reduction in carotid atherosclerosis
Kent, S. M., Coyle, L. C., Flaherty, P. J., et al. (2004) · Clinical Cardiology · doi:10.1002/clc.4960270105 · Cited by 30 · see citing works
Glycation of plasma low density lipoproteins increases interaction with arterial proteoglycans
Edwards, I. J., Wagner, J. D., Litwak, K. N., Rudel, L. L., & Cefalu, W. T. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00074-1 · Cited by 30 · see citing works
Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
Tannock, L. R., Little, P. J., Tsoi, C., Barrett, P. H. R., Wight, T. N., & Chait, A. (2004) · Diabetologia · doi:10.1007/s00125-004-1358-y · Cited by 30 · see citing works
Dietary polyunsaturated fat decreases interaction between low density lipoproteins and arterial proteoglycans
Manning, J. M., Gebre, A. K., Edwards, I. J., Wagner, W. D., Rudel, L. L., & Parks, J. S. (1994) · Lipids · doi:10.1007/bf02536098 · Cited by 30 · see citing works
Lipoprotein interaction with artery wall derived proteoglycan: comparisons between atherosclerosis-susceptible WC-2 and resistant Show Racer pigeons
Steele, R. H., & Wagner, W. D. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90008-6 · Cited by 29 · see citing works
A cholesterol tether
Staels, B. (2002) · Nature · doi:10.1038/417699a · Cited by 28 · see citing works
Overexpression of Decorin by Rat Arterial Smooth Muscle Cells Enhances Contraction of Type I Collagen In Vitro
Järveläinen, H., Vernon, R. B., Gooden, M. D., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000107026.98626.3b · Cited by 28 · see citing works
Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys
Edwards, I. J., Wagner, J. D., Vogl-Willis, C. A., Litwak, K. N., & Cefalu, W. T. (2004) · Cardiovascular Diabetology · doi:10.1186/1475-2840-3-6 · Cited by 28 · see citing works
Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices
Chang, M. Y., Potter‐Perigo, S., Wight, T. N., & Chait, A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31645-x · Cited by 28 · see citing works
Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL
Meyers, C. D., Tannock, L. R., Wight, T. N., & Chait, A. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300252-jlr200 · Cited by 26 · see citing works
Retention of atherogenic lipoproteins in atherogenesis
Gustafsson, M. V., Flood, C., Jirholt, P., & Bor�n, J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3262-x · Cited by 25 · see citing works
Self-citation
The use of fibrates and of statins in preventing atherosclerosis in diabetes
Steiner, G. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200112000-00003 · Cited by 19 · see citing works
The physical state of the LDL core influences the conformation of apolipoprotein B‐100 on the lipoprotein surface
Coronado‐Gray, A., & van Antwerpen, R. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03731-6 · Cited by 17 · see citing works
Modulation of vascular smooth muscle cells proteoglycan synthesis by the extracellular matrix
Figueroa, J. E., Oubre, J., & Vijayagopal, P. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10414 · Cited by 16 · see citing works
Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans
Edwards, I. J., Terry, J. G., Bell–Farrow, A. D., et al. (2002) · Metabolism · doi:10.1053/meta.2002.35177 · Cited by 14 · see citing works
Native and minimally oxidized low density lipoprotein depress smooth muscle matrix metalloproteinase levels
Wilson, D. L., Massaeli, H., Pierce, G. N., & Zahradka, P. C. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9236-9_18 · Cited by 12 · see citing works
Native and minimally oxidized low density lipoprotein depress smooth muscle matrix metalloproteinase levels
Wilson, D. L., Massaeli, H., Pierce, G. N., & Zahradka, P. C. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024794924217 · Cited by 10 · see citing works
Hydrolytic Enzymes Released From Resident Macrophages and Located in the Intima Extracellular Matrix as Agents That Modify Retained Apolipoprotein B Lipoproteins
Camejo, G. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000080647.77287.dd · Cited by 7 · see citing works
Association of hepatic lipase with proteoglycans stimulates the production of proteoglycans in vivo and in vitro
Lee, S., Kadambi, S., David, C., et al. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300372-jlr200 · Cited by 3 · see citing works
Untitled work
Komuro (2001) · doi:10.1002/1529-0131(200112)44:12

Flagged first, then by citations

Sorted by citations

The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
Borén, J., Packard, C. J., & Taskinen, M.-R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00474 · Cited by 196 · see citing works
Self-citation
Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2
Derbali, H., Bossé, Y., Côté, N., Pibarot, P., Audet, A., Pépin, A., Arsenault, B., Couture, C., Després, J.-P., & Mathieu, P. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090541 · Cited by 71 · see citing works
Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study
Yamauchi, Y., Deguchi, N., Takagi, C., Tanaka, M., Dhanasekaran, P., Nakano, M., Handa, T., Phillips, M. C., Lund-Katz, S., & Saito, H. (2008) · Biochemistry · doi:10.1021/bi8003999 · Cited by 53 · see citing works

Apolipoprotein A-1 and apolipoprotein B containing lipoprotein particles in coronary patients treated with extracorporal low density lipoprotein precipitation (HELP)
Koren, E., Armstrong, V. W., Müller, G., Wilson, P. R., Schuff‐Werner, P., Thiery, J., Eisenhauer, T., Alaupovic, P., & Seidel, D. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90019-d · Cited by 9 · see citing works
Lipoprotein Heterogeneity and its Effect on Apolipoprotein Assays
Fruchart, J. (1990) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519009091086 · Cited by 11 · see citing works
Radioimmunoassay of human high density lipoprotein apoprotein A-I
FAINARU, M., Glangeaud, M. C., & Eisenberg, S. (1975) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(75)90286-x · Cited by 137 · see citing works
Lipoprotein Heterogeneity and its Effect on Apolipoprotein Assays
Fruchart, J. (1990) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519009091086 · Cited by 7 · see citing works
Lipoprotein (a) and Low‐density lipoprotein apolipoprotein B metabolism following apheresis in patients with elevated lipoprotein(a) and coronary artery disease
Ma, L., Waldmann, E., Ooi, E. M. M., Chan, D. C., Barrett, P. H. R., Watts, G. F., & Parhofer, K. G. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13053 · Cited by 14 · see citing works

Authors: Gustafsson, M., & Borén, J.
Affiliations: University of Gothenburg (SE)
Corresponding author: Gustafsson, Maria
ORCID: Gustafsson, Maria
Borén, Jan
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-10
Volume: 15
Issue: 5
Pages: 505-514
ISSN: 0957-9672 (ISSN-L)
DOI: 10.1097/00041433-200410000-00003
OpenAlex: W1980560570
Cited by: 75
References: 101
Citations by year: 2024: 5 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 6
FWCI: 0.33
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Lipidology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: lipoprotein retention, extracellular matrix, proteoglycans, atherogenesis, apolipoprotein B, atherogenic lipoproteins, bridging molecules, lipoprotein modification, atherosclerosis, atherosclerosis treatment
MeSH terms: Animals, Apolipoproteins B, Arteriosclerosis, Cardiovascular Diseases, Extracellular Matrix, Humans, Lipoproteins, Models, Biological, Proteoglycans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanism of lipoprotein retention by the extracellular matrix

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks