The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension
Abstract
PURPOSE OF REVIEW: Oxidative stress is frequently associated with, and is partly involved in, the pathogenesis of chronic renal failure, hypertension and their complications. In the past few years, considerable progress has been made in deciphering the impact and the molecular mechanism of oxidative stress in these disorders. This article is intended to provide an overview of oxidative stress in hypertension and chronic renal failure. RECENT FINDINGS: Recent studies have provided irrefutable evidence that oxidative stress can cause hypertension and hypertension can cause oxidative stress. The upregulation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase and the tubulointerstitial accumulation of activated T cells, macrophages and superoxide-producing cells are partly responsible for oxidative stress in several models of hypertension. Antioxidant therapy alleviates hypertension, averts nuclear factor kappa B activation, and mitigates tubulointerstitial inflammation in hypertensive animals. Oxidative stress contributes to hypertension, endothelial dysfunction and brain disorders in chronic renal failure animals, and is partly caused by the upregulation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase and the downregulation of superoxide dismutase. SUMMARY: Oxidative stress, hypertension and inflammation are closely interrelated and involve a spiralling vicious cycle that can lead to progressive deterioration of hypertension and target organ damage.
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Cites
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
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The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia
Himmelfarb, J., Stenvinkel, P., Ikizler, T. A., & Hakim, R. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00600.x · Cited by 1,179
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Review Articles: Inflammation in End‐stage Renal Disease: Sources, Consequences, and Therapy
Stenvinkel, P., & Alvestrand, A. (2002) · Seminars in Dialysis · doi:10.1046/j.1525-139x.2002.00083.x · Cited by 425
Chen, X., Touyz, R. M., Park, J. B., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/hy09t1.094005 · Cited by 410
Induction of Oxidative Stress by Glutathione Depletion Causes Severe Hypertension in Normal Rats
Vaziri, N. D., Wang, X. Q., Oveisi, F., & Rad, B. (2000) · Hypertension · doi:10.1161/01.hyp.36.1.142 · Cited by 400
Self-citationChabrashvili, T., Tojo, A., Onozato, M. L., Kitiyakara, C., Quinn, M. T., Fujita, T., Welch, W. J., & Wilcox, C. S. (2002) · Hypertension · doi:10.1161/hy0202.103264 · Cited by 377
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Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency
Vaziri, N. D., Dicus, M., Ho, N. D., Boroujerdi-Rad, L., & Sindhu, R. K. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00702.x · Cited by 335
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Cited by
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Srivastava, S. K., Ramana, K. V., & Bhatnagar, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0028 · Cited by 527
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Roberts, C. K., Barnard, R. J., Sindhu, R. K., Jurczak, M., Ehdaie, A., & Vaziri, N. D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.022 · Cited by 322
Self-citationOxidative stress in chronic kidney disease
Ling, X. C., & Kuo, K.-L. (2018) · Renal Replacement Therapy · doi:10.1186/s41100-018-0195-2 · Cited by 183
Metadata
- Authors
- Vaziri, N. D.
- Venue
- Current Opinion in Nephrology and Hypertension
- Published
- 2004-01
- Volume
- 13
- Issue
- 1
- Pages
- 93-99
- ISSN
- 1062-4821 (ISSN-L)
- OpenAlex
- W1969782978
- Cited by
- 253
- References
- 37
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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