Renal Autoregulation in Health and Disease
Open accessAbstract
Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80–180 mmHg). Such autoregulation is mediated largely by the myogenic and the macula densa-tubuloglomerular feedback (MD-TGF) responses that regulate preglomerular vasomotor tone primarily of the afferent arteriole. Differences in response times allow separation of these mechanisms in the time and frequency domains. Mechanotransduction initiating the myogenic response requires a sensing mechanism activated by stretch of vascular smooth muscle cells (VSMCs) and coupled to intracellular signaling pathways eliciting plasma membrane depolarization and a rise in cytosolic free calcium concentration ([Ca 2+ ] i ). Proposed mechanosensors include epithelial sodium channels (ENaC), integrins, and/or transient receptor potential (TRP) channels. Increased [Ca 2+ ] i occurs predominantly by Ca 2+ influx through L-type voltage-operated Ca 2+ channels (VOCC). Increased [Ca 2+ ] i activates inositol trisphosphate receptors (IP 3 R) and ryanodine receptors (RyR) to mobilize Ca 2+ from sarcoplasmic reticular stores. Myogenic vasoconstriction is sustained by increased Ca 2+ sensitivity, mediated by protein kinase C and Rho/Rho-kinase that favors a positive balance between myosin light-chain kinase and phosphatase. Increased RPP activates MD-TGF by transducing a signal of epithelial MD salt reabsorption to adjust afferent arteriolar vasoconstriction. A combination of vascular and tubular mechanisms, novel to the kidney, provides for high autoregulatory efficiency that maintains RBF and GFR, stabilizes sodium excretion, and buffers transmission of RPP to sensitive glomerular capillaries, thereby protecting against hypertensive barotrauma. A unique aspect of the myogenic response in the renal vasculature is modulation of its strength and speed by the MD-TGF and by a connecting tubule glomerular feedback (CT-GF) mechanism. Reactive oxygen species and nitric oxide are modulators of myogenic and MD-TGF mechanisms. Attenuated renal autoregulation contributes to renal damage in many, but not all, models of renal, diabetic, and hypertensive diseases. This review provides a summary of our current knowledge regarding underlying mechanisms enabling renal autoregulation in health and disease and methods used for its study.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple factors could contribute to renal vasodilation in obesity, including compression of the renal tubules, hyperglycaemia, high protein intake, hyperinsulinaemia and increased blood pressure combined with impaired renal autoregulation.
“Multiple factors could contribute to renal vasodilation in obesity, including compression of the renal tubules, hyperglycaemia, high protein intake, hyperinsulinaemia and increased BP combined with impaired renal autoregulation6,43,44.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Dubroca, C., Loyer, X., Retailleau, K., Loirand, G., Pacaud, P., Féron, O., Balligand, J., Levy, B. I., Heymes, C., & Henrion, D. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.020 · Cited by 62 · see citing works
RetractedCalcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493 · see citing works
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987 · see citing works
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
Owens, G. K., Kumar, M. S., & Wamhoff, B. R. (2004) · Physiological Reviews · doi:10.1152/physrev.00041.2003 · Cited by 3,472 · see citing works
The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
Parving, H.-H., Lehnert, H., Bröchner-Mortensen, J., Gomis, R., Andersen, S., & Arner, P. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011489 · Cited by 2,873 · see citing works
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735 · see citing works
Development of a Strain of Spontaneously Hypertensive Rats
OKAMOTO, K., & AOKI, K. (1963) · Japanese Circulation Journal · doi:10.1253/jcj.27.282 · Cited by 2,545 · see citing works
[Effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes].
Parving, H., Lehnert, H., Brøchner‐Mortensen, J., Gomis, R., Andersen, S., & Arner, P. (2001) · PubMed · Cited by 2,527 · see citing works
Prostanoid Receptors: Structures, Properties, and Functions
Narumiya, S., Sugimoto, Y., & Ushikubi, F. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1193 · Cited by 2,414 · see citing works
Klahr, S., Levey, A. S., Beck, G. J., Caggiula, A. W., Hunsicker, L., Kusek, J. W., & Striker, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301301 · Cited by 2,328 · see citing works
Physiological roles and properties of potassium channels in arterial smooth muscle
Nelson, M. T., & Quayle, J. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.4.c799 · Cited by 2,161 · see citing works
STUDIES ON EXPERIMENTAL HYPERTENSION
Goldblatt, H., Lynch, J., Hanzal, R. F., & Summerville, W. W. (1934) · The Journal of Experimental Medicine · doi:10.1084/jem.59.3.347 · Cited by 2,145 · see citing works
Handbuch der speziellen pathologischen Anatomie und Histologie.
Henke, F., & Lubarsch, O. (1926) · JAMA · doi:10.1001/jama.1926.02670520042027 · Cited by 2,094 · see citing works
Somlyo, A. P., & Somlyo, A. V. (2003) · Physiological Reviews · doi:10.1152/physrev.00023.2003 · Cited by 1,980 · see citing works
Hypertension : pathophysiology, diagnosis, and management
Laragh, J. H., & Brenner, B. M. (1995) · Raven Press eBooks · Cited by 1,935 · see citing works
Diabetic nephropathy: diagnosis, prevention, and treatment
Gross, J. L., de Azevedo, M. J., Silveiro, S. P., Canani, L. H., Caramori, M. L., & Zelmanovitz, T. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.164 · Cited by 1,839 · see citing works
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736 · see citing works
Sodium/Calcium Exchange: Its Physiological Implications
Blaustein, M. P., & Lederer, W. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.3.763 · Cited by 1,736 · see citing works
Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation
Hostetter, T. H., Olson, J. L., Rennke, H. G., Venkatachalam, M. A., & Brenner, B. M. (1981) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1981.241.1.f85 · Cited by 1,681 · see citing works
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,654 · see citing works
Cellular mechanotransduction: putting all the pieces together again
Ingber, D. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-5424rev · Cited by 1,627 · see citing works
Mann, J. F. E., Schmieder, R. E., McQueen, M., Dyal, L., Schumacher, H., Pogue, J. M., Wang, X., Maggioni, A. P., Budaj, A., Chaithiraphan, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61236-2 · Cited by 1,581 · see citing works
On the local reactions of the arterial wall to changes of internal pressure
Bayliss, W. M. (1902) · The Journal of Physiology · doi:10.1113/jphysiol.1902.sp000911 · Cited by 1,526 · see citing works
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499 · see citing works
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T. W., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,496 · see citing works
Zhang, S. L., Yu, Y., Roos, J., Kozak, J. A., Deerinck, T. J., Ellisman, M. H., Stauderman, K. A., & Cahalan, M. D. (2005) · Nature · doi:10.1038/nature04147 · Cited by 1,374 · see citing works
Kobori, H., Nangaku, M., Navar, L. G., & Nishiyama, A. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.3 · Cited by 1,232 · see citing works
Neural control of renal function
DiBona, G. F., & Kopp, U. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.1.75 · Cited by 1,212 · see citing works
Neural Control of Renal Function*
Kopp, U. C., & DiBona, G. F. (2020) · Reflex Control of the Circulation · doi:10.1201/9780367813338-17 · Cited by 1,126 · see citing works
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Francis, S. H., Busch, J. L., & Corbin, J. D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002907 · Cited by 1,025 · see citing works
Signaling Mechanisms Underlying the Vascular Myogenic Response
Davis, M. J., & Hill, M. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.387 · Cited by 993 · see citing works
de Zeeuw, D., Remuzzi, G., Parving, H., Keane, W. F., Zhang, Z., Shahinfar, S., Snapinn, S., Cooper, M. E., Mitch, W. E., & Brenner, B. M. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00653.x · Cited by 963 · see citing works
Agodoa, L. Y. C. (2001) · JAMA · doi:10.1001/jama.285.21.2719 · Cited by 935 · see citing works
Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.
Anderson, S., Meyer, T. W., Rennke, H. G., & Brenner, B. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112013 · Cited by 933 · see citing works
The hyperfiltration theory: A paradigm shift in nephrology
Brenner, B. M., Lawler, E. V., & Mackenzie, H. S. (1996) · Kidney International · doi:10.1038/ki.1996.265 · Cited by 875 · see citing works
Schrier, R. W., Estacio, R. O., Esler, A. L., & Mehler, P. S. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00213.x · Cited by 843 · see citing works
Protein carbonylation, cellular dysfunction, and disease progression
Dalle‐Donne, I., Aldini, G., Carini, M., Colombo, R., Rossi, R., & Milzani, A. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00407.x · Cited by 836 · see citing works
Glomerular hemodynamics in experimental diabetes mellitus
Hostetter, T. H., Troy, J. L., & Brenner, B. M. (1981) · Kidney International · doi:10.1038/ki.1981.33 · Cited by 794 · see citing works
APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
Parsa, A., Kao, W. H. L., Xie, D., Astor, B. C., Li, M., Hsu, C., Feldman, H. I., Parekh, R. S., Kusek, J. W., Greene, T., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1310345 · Cited by 786 · see citing works
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773 · see citing works
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 768 · see citing works
Paracrine regulation of the renal microcirculation
Navar, L. G., Inscho, E. W., Majid, S. A., Imig, J. D., Harrison‐Bernard, L. M., & Mitchell, K. D. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.2.425 · Cited by 737 · see citing works
NADPH Oxidases, Reactive Oxygen Species, and Hypertension
Paravicini, T. M., & Touyz, R. M. (2008) · Diabetes Care · doi:10.2337/dc08-s247 · Cited by 723 · see citing works
(1973) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3288-6 · Cited by 708 · see citing works
Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function
Bax, L., Woittiez, A.-J. J., Kouwenberg, H. J., Mali, W. P. T. M., Buskens, E., Beek, F. J. A., Braam, B. G., Huysmans, F. T. M., Kool, L. J. S., Rutten, M. J. C. M., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00119 · Cited by 699 · see citing works
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Zou, Y., Akazawa, H., Qin, Y., Sano, M., Takano, H., Minamino, T., Makita, N., Iwanaga, K., Zhu, W., Kudoh, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1137 · Cited by 685 · see citing works
Glomerular hyperfiltration: definitions, mechanisms and clinical implications
Helal, I., Fick-Brosnahan, G. M., Reed-Gitomer, B., & Schrier, R. W. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.19 · Cited by 673 · see citing works
STIM proteins: dynamic calcium signal transducers
Soboloff, J., Rothberg, B. S., Madesh, M., & Gill, D. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3414 · Cited by 661 · see citing works
Intracellular cyclic GMP receptor proteins
Lincoln, T., & Cornwell, T. L. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.2.7680013 · Cited by 651 · see citing works
Reactive oxygen species in vascular biology: implications in hypertension
Touyz, R. M., & Schiffrin, E. L. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0696-7 · Cited by 646 · see citing works
Nephron adaptation to renal injury or ablation
Brenner, B. M. (1985) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1985.249.3.f324 · Cited by 643 · see citing works
Nitric oxide activates TRP channels by cysteine S-nitrosylation
Yoshida, T., Inoue, R., Morii, T., Takahashi, N., Yamamoto, S., Hara, Y., Tominaga, M., Shimizu, S., Sato, Y., & Mori, Y. (2006) · Nature Chemical Biology · doi:10.1038/nchembio821 · Cited by 566 · see citing works
X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart
Prosser, B. L., Ward, C. W., & Lederer, W. J. (2011) · Science · doi:10.1126/science.1202768 · Cited by 564 · see citing works
Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.
Agrawal, S., Temsamani, J., & Tang, J. Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7595 · Cited by 564 · see citing works
PERMEATION AND SELECTIVITY OF TRP CHANNELS
Owsianik, G., Talavera, K., Voets, T., & Nilius, B. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.101406 · Cited by 548 · see citing works
NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
Mohazzab, K. M., Kaminski, P. M., & Wolin, M. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.6.h2568 · Cited by 536 · see citing works
Zatz, R., Meyer, T. W., Rennke, H. G., & Brenner, B. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5963 · Cited by 524 · see citing works
Diabetic kidney disease in thedb/dbmouse
Sharma, K., McCue, P. A., & DUNN, S. R. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00315.2002 · Cited by 521 · see citing works
Nitric oxide synthase in macula densa regulates glomerular capillary pressure.
Wilcox, C. S., Welch, W. J., Murad, F., Gross, S. S., Taylor, G., Levi, R. C., & Schmidt, H. H. H. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11993 · Cited by 520 · see citing works
Self-citationA common mechanism underlies stretch activation and receptor activation of TRPC6 channels
Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J., & Gill, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606894103 · Cited by 517 · see citing works
Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries
Welsh, D. G., Morielli, A. D., Nelson, M. T., & Brayden, J. E. (2002) · Circulation Research · doi:10.1161/hh0302.105662 · Cited by 513 · see citing works
Folkow, B., GRIYBY, G., & Thulesius, O. (1958) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1958.tb01626.x · Cited by 511 · see citing works
Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice
Dietrich, A., y Schnitzler, M. M., Gollasch, M., Groß, V., Storch, U., Dubrovska, G., Obst, M., Yildirim, E., Salanova, B., Kalwa, H., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6980-6989.2005 · Cited by 510 · see citing works
Connexin 43 Hemichannels Are Permeable to ATP
Kang, J., Kang, N., Lovatt, D., Torres, A., Zhao, Z., Lin, J. H.-C., & Nedergaard, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5048-07.2008 · Cited by 507 · see citing works
Similarities of genetic (spontaneous) hypertension. Man and rat.
Trippodo, N. C., & Frohlich, E. D. (1981) · Circulation Research · doi:10.1161/01.res.48.3.309 · Cited by 505 · see citing works
Schnackenberg, C. G., Welch, W. J., & Wilcox, C. S. (1998) · Hypertension · doi:10.1161/01.hyp.32.1.59 · Cited by 498 · see citing works
Self-citationAvosentan for Overt Diabetic Nephropathy
Mann, J. F. E., Green, D., Jamerson, K., Ruilope, L. M., Kuranoff, S., Littke, T., & Viberti, G. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060593 · Cited by 493 · see citing works
Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?
Wilcox, C. S. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00250.2005 · Cited by 479 · see citing works
Self-citationAngiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature
Cat, A. N. D., Montezano, A. C. I., Burger, D. E., & Touyz, R. M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4641 · Cited by 469 · see citing works
Gill, P. S., & Wilcox, C. S. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1597 · Cited by 461 · see citing works
Self-citationOxidative Stress and Hypertension
Harrison, D. G., & Góngora, M. C. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.015 · Cited by 451 · see citing works
Vallon, V., Mühlbauer, B., & Oßwald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 450 · see citing works
The Dynamics of Glomerular Ultrafiltration in the Rat
Brenner, B. M., Troy, J. L., & Daugharty, T. M. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106667 · Cited by 428 · see citing works
Pathophysiology of Hypertensive Renal Damage
BIDANI, A. K., & Griffin, K. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000145180.38707.84 · Cited by 427 · see citing works
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
MD, P. D. (2006) · CRC Press eBooks · doi:10.1201/9781420005844 · Cited by 422 · see citing works
Earley, S., Waldron, B. J., & Brayden, J. E. (2004) · Circulation Research · doi:10.1161/01.res.0000147311.54833.03 · Cited by 403 · see citing works
Sun, D., Samuelson, L. C., Yang, T., Huang, Y. G., Paliege, A., Saunders, T. L., Briggs, J., & Schnermann, J. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171317998 · Cited by 402 · see citing works
Vascular NADPH oxidases: molecular mechanisms of activation
Brandes, R. P., & Kreuzer, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.007 · Cited by 396 · see citing works
Lüscher, T. F., Creager, M. A., Beckman, J. A., & Cosentino, F. (2003) · Circulation · doi:10.1161/01.cir.0000089189.70578.e2 · Cited by 392 · see citing works
Gq‐coupled receptors as mechanosensors mediating myogenic vasoconstriction
y Schnitzler, M. M., Storch, U., Meibers, S., Nurwakagari, P., Breit, A., Essin, K., Gollasch, M., & Gudermann, T. W. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.233 · Cited by 379 · see citing works
Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides
Wilcox, C. S., & Pearlman, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000240 · Cited by 377 · see citing works
Self-citationChabrashvili, T., Tojo, A., Onozato, M. L., Kitiyakara, C., Quinn, M. T., Fujita, T., Welch, W. J., & Wilcox, C. S. (2002) · Hypertension · doi:10.1161/hy0202.103264 · Cited by 377 · see citing works
Self-citationInteraction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy
Cooper, M. E. (2001) · Diabetologia · doi:10.1007/s001250100000 · Cited by 375 · see citing works
Schnackenberg, C. G., & Wilcox, C. S. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.424 · Cited by 375 · see citing works
Self-citationOxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB
Onozato, M. L., Tojo, A., Goto, A., Fujita, T., & Wilcox, C. S. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00123.x · Cited by 374 · see citing works
Self-citationPressure-dependent membrane depolarization in cat middle cerebral artery.
Harder, D. R. (1984) · Circulation Research · doi:10.1161/01.res.55.2.197 · Cited by 374 · see citing works
Transient Receptor Potential Channels in Cardiovascular Function and Disease
Inoue, R., Jensen, L. J., Shi, J., Morita, H., Nishida, M., Honda, A., & Ito, Y. (2006) · Circulation Research · doi:10.1161/01.res.0000233356.10630.8a · Cited by 366 · see citing works
Thurau, K., & Schnermann, J. (1965) · Journal of Molecular Medicine · doi:10.1007/bf01483845 · Cited by 363 · see citing works
Low-frequency oscillations of the laser Doppler perfusion signal in human skin
Kvandal, P., Landsverk, S. A., Bernjak, A., Stefanovska, A., Kvernmo, H. D., & Kirkebøen, K. A. (2006) · Microvascular Research · doi:10.1016/j.mvr.2006.05.006 · Cited by 363 · see citing works
Raychowdhury, M. K., Yukawa, M., Collins, L. J., McGrail, S. H., Kent, K. C., & Ware, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32161-0 · Cited by 353 · see citing works
Chronic effects of dietary protein in the rat with intact and reduced renal mass
Hostetter, T. H., Meyer, T. W., Rennke, H. G., Brenner, B. M., Noddin, W. T. T. A. O. J. A., & Sandstrom, D. J. (1986) · Kidney International · doi:10.1038/ki.1986.215 · Cited by 351 · see citing works
Magee, G., Bilous, R., Cardwell, C., Hunter, S., Kee, F., & Fogarty, D. (2009) · Diabetologia · doi:10.1007/s00125-009-1268-0 · Cited by 349 · see citing works
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
McCurley, A., Pires, P. W., Bender, S. B., Aronovitz, M. A., Zhao, M. J., METZGER, D., Chambon, P., Hill, M. A., Dorrance, A. M., Mendelsohn, M. E., et al. (2012) · Nature Medicine · doi:10.1038/nm.2891 · Cited by 349 · see citing works
Olson, J. L., Hostetter, T. H., Rennke, H. G., Brenner, B. M., & Venkatachalam, M. A. (1982) · Kidney International · doi:10.1038/ki.1982.143 · Cited by 348 · see citing works
Macrophage Phenotype Modulation by CXCL4 in Atherosclerosis
Gleissner, C. A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00001 · Cited by 346 · see citing works
Vasomotion: Mechanisms and Physiological Importance
Nilsson, H. (2003) · Molecular Interventions · doi:10.1124/mi.3.2.79 · Cited by 344 · see citing works
Polycystin-1 and -2 Dosage Regulates Pressure Sensing
Sharif‐Naeini, R., Folgering, J. H. A., Bichet, D., Duprat, F., Lauritzen, I., Arhatte, M., Jodar, M., Dedman, A., Chatelain, F. C., Schulte, U., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.045 · Cited by 341 · see citing works
Aldosterone: effects on the kidney and cardiovascular system
Briet, M. B., & Schiffrin, E. L. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.30 · Cited by 337 · see citing works
Shipley, R. E., & Study, R. S. (1951) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1951.167.3.676 · Cited by 330 · see citing works
Chabrashvili, T., Kitiyakara, C., Blau, J., Karber, A., Aslam, S., Welch, W. J., & Wilcox, C. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00476.2002 · Cited by 322 · see citing works
Self-citationCellular mechanisms involved in the vascular myogenic response
Meininger, G. A., & Davis, M. J. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.3.h647 · Cited by 318 · see citing works
Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow
Gebremedhin, D., Lange, A. R., Lowry, T. F., Taheri, M. R., Birks, E. K., Hudetz, A. G., Narayanan, J., Falck, J. R., Okamoto, H., Roman, R. J., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.1.60 · Cited by 318 · see citing works
Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats.
Rapp, J. P., & Dene, H. (1985) · Hypertension · doi:10.1161/01.hyp.7.3.340 · Cited by 308 · see citing works
JAGGAR, WELLMAN, HEPPNER, Porter, PEREZ, GOLLASCH, KLEPPISCH, RUBART, Stevenson, Lederer, et al. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.00462.x · Cited by 302 · see citing works
Heme oxygenase-1: A provenance for cytoprotective pathways in the kidney and other tissues
Nath, K. A. (2006) · Kidney International · doi:10.1038/sj.ki.5001565 · Cited by 301 · see citing works
Production and Actions of Superoxide in the Renal Medulla
Zou, A.-P., Li, N., & Cowley, A. W. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.547 · Cited by 297 · see citing works
Selkurt, E. E. (1951) · Circulation · doi:10.1161/01.cir.4.4.541 · Cited by 297 · see citing works
Effects of NADPH oxidase inhibitor in diabetic nephropathy
Asaba, K., Tojo, A., Onozato, M. L., Goto, A., Quinn, M. T., Fujita, T., & Wilcox, C. S. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00287.x · Cited by 296 · see citing works
Self-citationControl of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation
Hall, J. E. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.6.r960 · Cited by 286 · see citing works
Handbuch der speziellen pathologischen Anatomie und Histologie
(1958) · JAMA · doi:10.1001/jama.1958.03000080182034 · Cited by 286 · see citing works
Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels
Edwards, R. M. (1983) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1983.244.5.f526 · Cited by 283 · see citing works
The renal handling of amino acids and oligopeptides.
Silbernagl, S. (1988) · Physiological Reviews · doi:10.1152/physrev.1988.68.3.911 · Cited by 282 · see citing works
Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension.
Dworkin, L. D., Hostetter, T. H., Rennke, H. G., & Brenner, B. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111349 · Cited by 281 · see citing works
Somers, M. J., Mavromatis, K., Galis, Z. S., & Harrison, D. G. (2000) · Circulation · doi:10.1161/01.cir.101.14.1722 · Cited by 280 · see citing works
Macula densa cell signaling involves ATP release through a maxi anion channel
Bell, P. D., Lapointe, J., Sabirov, R. Z., Hayashi, S., Peti‐Peterdi, J., Manabe, K.-I., Kovács, G., & Okada, Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0736323100 · Cited by 280 · see citing works
Loutzenhiser, R., Griffin, K. A., Williamson, G. A., & BIDANI, A. K. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00402.2005 · Cited by 280 · see citing works
Prostaglandin E receptors and the kidney
Breyer, M. D., & BREYER, R. M. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.1.f12 · Cited by 273 · see citing works
Revisiting TRPC1 and TRPC6 mechanosensitivity
Gottlieb, P. A., Folgering, J. H. A., Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Bowman, C. L., Bichet, D., Patel, A. J., Sachs, F., et al. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0359-3 · Cited by 271 · see citing works
Knot, H. J., Standen, N. B., & Nelson, M. T. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.211br.x · Cited by 271 · see citing works
Dahl, L. M., Heine, M., & Thompson, K. H. (1977) · Circulation Research · doi:10.1161/01.res.40.4.94 · Cited by 269 · see citing works
Reversing glomerular hypertension stabilizes established glomerular injury
Meyer, T. W., Anderson, S., Rennke, H. G., & Brenner, B. M. (1987) · Kidney International · doi:10.1038/ki.1987.62 · Cited by 267 · see citing works
Bacterial Carbonic Anhydrases as Drug Targets: Toward Novel Antibiotics?
Supuran, C. T. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00034 · Cited by 267 · see citing works
The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury.
Kasiske, B. L., O’Donnell, M. P., & Keane, W. F. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i110 · Cited by 265 · see citing works
Iwamoto, T., Kita, S., Zhang, J., Blaustein, M. P., Arai, Y., Yoshida, S., Wakimoto, K., Komuro, I., & Katsuragi, T. (2004) · Nature Medicine · doi:10.1038/nm1118 · Cited by 264 · see citing works
Role of nitric oxide in the regulation of nephron transport
Ortiz, P. A., & Garvin, J. L. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00334.2001 · Cited by 264 · see citing works
Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261 · see citing works
Self-citationLoutzenhiser, R., BIDANI, A. K., & Chilton, L. (2002) · Circulation Research · doi:10.1161/01.res.0000024262.11534.18 · Cited by 261 · see citing works
Castrop, H., Höcherl, K., Kurtz, A., Schweda, F., Todorov, V., & Wagner, C. (2010) · Physiological Reviews · doi:10.1152/physrev.00011.2009 · Cited by 260 · see citing works
The myogenic response: established facts and attractive hypotheses
Schubert, R., & Mulvany, M. J. (1999) · Clinical Science · doi:10.1042/cs0960313 · Cited by 255 · see citing works
Dynamics of glomerular ultrafiltration in the rat. VII. Response to reduced renal mass
Deen, W. M., Maddox, D., Robertson, C. R., & Brenner, B. M. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.227.3.556 · Cited by 254 · see citing works
Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension
Vaziri, N. D. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200401000-00013 · Cited by 253 · see citing works
Hypothesis for the Initiation of Vasomotion
Peng, H., Matchkov, V. V., Ivarsen, A., Aalkjær, C., & Nilsson, H. (2001) · Circulation Research · doi:10.1161/hh0801.089603 · Cited by 252 · see citing works
Vasomotion – what is currently thought?
Aalkjær, C., Boedtkjer, D. B., & Matchkov, V. V. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02320.x · Cited by 251 · see citing works
Effect of Candesartan on Microalbuminuria and Albumin Excretion Rate in Diabetes
Bilous, R., Chaturvedi, N., Sjølie, A. K., Fuller, J., Klein, R., Orchard, T., Porta, M., & Parving, H.-H. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-1-200907070-00120 · Cited by 251 · see citing works
Functional analysis of selective interactions among rodent connexins.
White, T. W., Paul, D. L., Goodenough, D. A., & Bruzzone, R. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.4.459 · Cited by 250 · see citing works
Regulation of blood flow in the microcirculation: role of conducted vasodilation
Bagher, P., & Segal, S. S. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02244.x · Cited by 249 · see citing works
Johnson, P. C. (1991) · Humana Press eBooks · doi:10.1007/978-1-4612-0403-9_10 · Cited by 248 · see citing works
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
Ma, Y., Gebremedhin, D., Schwartzman, M. L., Falck, J. R., Clark, J. E., Masters, B. S. S., Harder, D. R., & Roman, R. J. (1993) · Circulation Research · doi:10.1161/01.res.72.1.126 · Cited by 247 · see citing works
Dietrich, A., Kalwa, H., Storch, U., y Schnitzler, M. M., Salanova, B., Pinkenburg, O., Dubrovska, G., Essin, K., Gollasch, M., Birnbaumer, L., et al. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0314-3 · Cited by 246 · see citing works
Quantitation of rhythmic diameter changes in arterial microcirculation
Colantuoni, A., Bertuglia, S., & Intaglietta, M. (1984) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1984.246.4.h508 · Cited by 244 · see citing works
Lipkowitz, M. S., Freedman, B. I., Langefeld, C. D., Comeau, M. E., Bowden, D. W., Kao, W. H. L., Astor, B. C., Böttinger, E. P., Iyengar, S. K., Klotman, P. E., et al. (2012) · Kidney International · doi:10.1038/ki.2012.263 · Cited by 244 · see citing works
Cipolla, M. J., Gokina, N. I., & Osol, G. (2002) · The FASEB Journal · doi:10.1096/cj.01-0104hyp · Cited by 237 · see citing works
Brown, R. D., Ollerstam, A., Johansson, B. A., Skøtt, O., Gebré‐Medhin, S., Fredholm, B. B., & Persson, A. E. G. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.5.r1362 · Cited by 234 · see citing works
Arteriolar Sclerosis in Hypertensive and Non-Hypertensive Individuals.
Moritz, A. R., & Oldt, M. R. (1937) · PubMed · Cited by 232 · see citing works
TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure
Earley, S., Pauyo, T., Drapp, R., Tavares, M. J., Liedtke, W., & Brayden, J. E. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00241.2009 · Cited by 232 · see citing works
The Renal Medulla and Hypertension
Cowley, A. W., Mattson, D. L., Lu, S., & Roman, R. J. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.663 · Cited by 226 · see citing works
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles
Imig, J. D., Zou, A. P., Stec, D. E., Harder, D. R., Falck, J. R., & Roman, R. J. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.1.r217 · Cited by 224 · see citing works
Ahmed, A., Kamath, N. S., Kossi, M. E., & Nahas, A. M. E. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp511 · Cited by 222 · see citing works
Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.
Zhao, X., Yamamoto, T., Newman, J. W. I., Kim, I.-H., Watanabe, T., Hammock, B. D., Stewart, J. P., Pollock, J. S., Pollock, D. M., & Imig, J. D. (2004) · PubMed · Cited by 222 · see citing works
Beswick, R. A., Zhang, H., Marable, D. R., Catravas, J. D., Hill, W., & Webb, R. C. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.781 · Cited by 221 · see citing works
Winternitz, S., Katholi, R. E., & Oparil, S. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109966 · Cited by 221 · see citing works
Effects of calcium antagonists on renal hemodynamics
Loutzenhiser, R., & Epstein, M. (1985) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1985.249.5.f619 · Cited by 217 · see citing works
Direct Demonstration of Macula Densa-Mediated Renin Secretion
Skøtt, O., & Briggs, J. P. (1987) · Science · doi:10.1126/science.3306925 · Cited by 216 · see citing works
Abboud, H. E. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.02.025 · Cited by 215 · see citing works
Ito, S., Johnson, C. S., & Carretero, O. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115181 · Cited by 215 · see citing works
Nephron pO2 and renal oxygen usage in the hypertensive rat kidney
Welch, W. J., Baumgärtl, H., Lübbers, D. W., & Wilcox, C. S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00483.x · Cited by 213 · see citing works
Self-citationMicrovascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats.
Harper, S. L., & Bohlen, H. G. (1984) · Hypertension · doi:10.1161/01.hyp.6.3.408 · Cited by 212 · see citing works
Role of nitric oxide in renal papillary blood flow and sodium excretion.
Mattson, D. L., Roman, R. J., & Cowley, A. W. (1992) · Hypertension · doi:10.1161/01.hyp.19.6.766 · Cited by 211 · see citing works
Ca2+Channel Subtypes and Pharmacology in the Kidney
Hayashi, K., Wakino, S., Sugano, N., Ozawa, Y., Homma, K., & Saruta, T. (2007) · Circulation Research · doi:10.1161/01.res.0000256155.31133.49 · Cited by 207 · see citing works
Mistry, D. K., & Garland, C. J. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701940 · Cited by 205 · see citing works
Role of renal NO production in the regulation of medullary blood flow
Cowley, A. W., Mori, T., Mattson, D. L., & Zou, A.-P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00701.2002 · Cited by 205 · see citing works
Deen, W. M., Troy, J. L., Robertson, C. R., & Brenner, B. M. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107324 · Cited by 204 · see citing works
Connexin40 Is Essential for the Pressure Control of Renin Synthesis and Secretion
Wagner, C., de Wit, C., Kurtz, L., Grünberger, C., Kurtz, A., & Schweda, F. (2007) · Circulation Research · doi:10.1161/01.res.0000258856.19922.45 · Cited by 202 · see citing works
Effects of genetic obesity on renal structure and function in the Zucker rat.
Kasiske, B. L., Cleary, M. P., O’Donnell, M. P., & Keane, W. F. (1985) · PubMed · Cited by 202 · see citing works
Nongenomic Vascular Action of Aldosterone in the Glomerular Microcirculation
Arima, S., Kohagura, K., Xu, H.-L., Sugawara, A., Abe, T., Satoh, F., Takeuchi, K., & Ito, S. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000083982.74108.54 · Cited by 201 · see citing works
Ungvari, Z. I., Csiszár, A., Huang, A., Kaminski, P. M., Wolin, M. S., & Koller, Á. (2003) · Circulation · doi:10.1161/01.cir.0000079165.84309.4d · Cited by 200 · see citing works
New Insights into Cardiac and Brain Sodium Channels Modulation by Beta Blockers
Chahine, M. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00001 · Cited by 199 · see citing works
Salamanca, D. A., & Khalil, R. A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.07.017 · Cited by 198 · see citing works
Dworkin, L. D., & Feiner, H. D. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112377 · Cited by 198 · see citing works
Renal nerves in the pathogenesis of hypertension in experimental animals and humans
Katholi, R. E. (1983) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1983.245.1.f1 · Cited by 197 · see citing works
Regulation by angiotensin II of its receptors in resistance blood vessels
Gunther, S., Gimbrone, M. A., & Alexander, R. W. (1980) · Nature · doi:10.1038/287230a0 · Cited by 197 · see citing works
Seldin and Giebisch's the kidney : physiology and pathophysiology
Seldin, D. W., Giebisch, G., Alpern, R. J., Moe, O. W., & Caplan, M. J. (2013) · Elsevier eBooks · Cited by 196 · see citing works
McDonough, A. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00002.2010 · Cited by 196 · see citing works
Hansen, P., Jensen, B. L., Andreasen, D., & Skøtt, O. (2001) · Circulation Research · doi:10.1161/hh1901.097126 · Cited by 196 · see citing works
Inhibition of 20-HETE Production Contributes to the Vascular Responses to Nitric Oxide
Alonso‐Galicia, M., Drummond, H. A., Reddy, K. K., Falck, J. R., & Roman, R. J. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.320 · Cited by 196 · see citing works
Abnormal renal hemodynamics in black salt-sensitive patients with hypertension.
Campese, V. M., Parise, M., Karubian, F., & Bigazzi, R. (1991) · Hypertension · doi:10.1161/01.hyp.18.6.805 · Cited by 195 · see citing works
Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats
Osol, G., & Halpern, W. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.249.5.h914 · Cited by 194 · see citing works
Effect of Telmisartan on Renal Outcomes
Mann, J. F. E., Schmieder, R. E., Dyal, L., McQueen, M. J., Schumacher, H., Pogue, J., Wang, X., Probstfield, J. L., Avezum, Á., Cardona-Munoz, E., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-1-200907070-00122 · Cited by 194 · see citing works
Selkurt, E. E., Hall, P. W., & Spencer, M. P. (1949) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1949.159.2.369 · Cited by 194 · see citing works
Mechanisms of renal blood flow autoregulation: dynamics and contributions
Just, A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00332.2006 · Cited by 193 · see citing works
Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.
Ito, S., & Ren, Y. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116615 · Cited by 192 · see citing works
Brown Norway Chromosome 13 Confers Protection From High Salt to Consomic Dahl S Rat
Cowley, A. W., Roman, R. J., Kaldunski, M. L., Dumas, P., Dickhout, J. G., Greene, A. S., & Jacob, H. J. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.456 · Cited by 192 · see citing works
Assessment of renal autoregulation.
Cupples, W., & Braam, B. (2007) · AJP - Renal Physiology · doi:10.1152/ajprenal.00194.2006 · Cited by 191 · see citing works
Cancela, J., Gerasimenko, O. V., Gerasimenko, J. V., Tepikin, A. V., & Petersen, O. H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2549 · Cited by 190 · see citing works
Paradoxes of nitric oxide in the diabetic kidney
Komers, R., & Anderson, S. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00265.2002 · Cited by 190 · see citing works
Freedman, B. I., Hicks, P. J., Bostrom, M. A., Cunningham, M. E., Liu, Y., Divers, J., Kopp, J. B., Winkler, C. A., Nelson, G. W., Langefeld, C. D., et al. (2009) · Kidney International · doi:10.1038/ki.2008.701 · Cited by 188 · see citing works
Chloride channel blockers inhibit myogenic tone in rat cerebral arteries
Nelson, M. T., Conway, M. A., Knot, H. J., & Brayden, J. E. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.259bk.x · Cited by 188 · see citing works
Aalkjær, C., & Nilsson, H. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706084 · Cited by 187 · see citing works
Oxidative Stress in Hypertension: Role of the Kidney
Araújo, M., & Wilcox, C. S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5259 · Cited by 187 · see citing works
Self-citationDynamics of glomerular ultrafiltration in the rat. 3. Hemodynamics and autoregulation
Robertson, C. R., Deen, W. M., Troy, J. L., & Brenner, B. M. (1972) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1972.223.5.1191 · Cited by 187 · see citing works
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
Leffler, C. W., Parfenova, H., Jaggar, J. H., & Wang, R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00793.2005 · Cited by 186 · see citing works
Renal autoregulation: perspectives from whole kidney and single nephron studies
Navar, L. G. (1978) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1978.234.5.f357 · Cited by 185 · see citing works
Castrop, H., Huang, Y. G., Hashimoto, S., Mizel, D. E., Hansen, P., Theilig, F., Bachmann, S., Deng, C., Briggs, J., & Schnermann, J. B. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21851 · Cited by 185 · see citing works
Integrins and mechanotransduction of the vascular myogenic response
Davis, M. J., Wu, X. Y., Nurkiewicz, T. R., Kawasaki, J., Davis, G. E., Hill, M. A., & Meininger, G. A. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.4.h1427 · Cited by 185 · see citing works
Kurtz, T. W., & Morris, R. C. (1987) · Hypertension · doi:10.1161/01.hyp.10.1.127 · Cited by 184 · see citing works
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity
Zou, A. P., Fleming, J. T., Falck, J. R., Jacobs, E. R., Gebremedhin, D., Harder, D. R., & Roman, R. J. (1996) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1996.270.5.f822 · Cited by 184 · see citing works
Taylor, N. E., Glocka, P., Liang, M., & Cowley, A. W. (2006) · Hypertension · doi:10.1161/01.hyp.0000203161.02046.8d · Cited by 183 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Li, Y., Liu, Y., Liu, S., Gao, M., Wang, W., Chen, K., Huang, L., & Liu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01400-z · Cited by 762 · see citing works
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
Schefold, J. C., Filippatos, G., Hasenfuss, G., Anker, S. D., & von Haehling, S. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.113 · Cited by 671 · see citing works
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654 · see citing works
Mitochondrial dysfunction in diabetic kidney disease
Forbes, J. M., & Thorburn, D. R. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2018.9 · Cited by 641 · see citing works
Diuretic Therapy for Patients With Heart Failure
Felker, G. M., Ellison, D. H., Müllens, W., Cox, Z. L., & Testani, J. M. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.059 · Cited by 460 · see citing works
Harjola, V., Müllens, W., Banaszewski, M., Bauersachs, J. K., Rocca, H. B., Chioncel, O., Collins, S. P., Doehner, W., Filippatos, G. S., Flammer, A. J., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.872 · Cited by 435 · see citing works
Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology
Ferrannini, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.011 · Cited by 338 · see citing works
Oxidative stress and the role of redox signalling in chronic kidney disease
Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 283 · see citing works
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273 · see citing works
Nitric oxide signalling in kidney regulation and cardiometabolic health
Carlström, M. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00429-z · Cited by 264 · see citing works
Self-citationCarlström, M., & Larsson, S. C. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy014 · Cited by 242 · see citing works
Self-citationGut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension
Jiang, S., Shui, Y., Cui, Y., Tang, C., Wang, X., Qiu, X., Hu, W., Fei, L., Li, Y., Zhang, S., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102115 · Cited by 237 · see citing works
Ferrannini, E., Baldi, S., Frascerra, S., Astiarraga, B., Barsotti, E., Clerico, A., & Muscelli, E. (2017) · Diabetes Care · doi:10.2337/dc16-2724 · Cited by 182 · see citing works
Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension
Hall, J. E. (2016) · Circulation · doi:10.1161/circulationaha.115.018526 · Cited by 152 · see citing works
Yu, Z., Coresh, J., Qi, G., Grams, M., Boerwinkle, E., Snieder, H., Teumer, A., Pattaro, C., Köttgen, A., Chatterjee, N., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.04.044 · Cited by 135 · see citing works
Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease
Griffin, K. A. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.08314 · Cited by 131 · see citing works
Tonneijck, L., Smits, M. M., Muskiet, M. H. A., Hoekstra, T., Kramer, M. H. H., Danser, A. H. J., Diamant, M., Joles, J. A., & van Raalte, D. H. (2016) · Diabetologia · doi:10.1007/s00125-016-3938-z · Cited by 126 · see citing works
Nephron Protection in Diabetic Kidney Disease
Anders, H., Davis, J. M., & Thurau, K. (2016) · New England Journal of Medicine · doi:10.1056/nejmcibr1608564 · Cited by 121 · see citing works
Personalized hemodynamic management
Saugel, B., Vincent, J., & Wagner, J. Y. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000422 · Cited by 115 · see citing works
Meng, L., Wang, Y., Zhang, L., & McDonagh, D. L. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003569 · Cited by 112 · see citing works
Oxidative stress as a potential target in acute kidney injury
Tomşa, A., Alexa, A. L., Junie, L. M., Răchişan, A. L., & Ciumărnean, L. (2019) · PeerJ · doi:10.7717/peerj.8046 · Cited by 112 · see citing works
Knock, G. A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.029 · Cited by 108 · see citing works
Microcirculation and Macrocirculation in Hypertension: A Dangerous Cross-Link?
Laurent, S., Rosei, C. A., Bruno, R. M., & Rizzoni, D. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.17962 · Cited by 108 · see citing works
What Makes the Kidney Susceptible to Hypoxia?
Evans, R. G., Smith, D. W., Lee, C. J., Ngo, J. P., & Gardiner, B. S. (2019) · The Anatomical Record · doi:10.1002/ar.24260 · Cited by 107 · see citing works
Téllez, L., Ibáñez, L., del Villar, C. P., Yotti, R., Martínez, J., Carrión, L., de Santiago, E. R., Rivera, M. E., González‐Mansilla, A., Pastor, Ó., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.011 · Cited by 107 · see citing works
“I don’t get no respect”: the role of chloride in acute kidney injury
Rein, J. L., & Coca, S. G. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00130.2018 · Cited by 104 · see citing works
Renal Denervation Update From the International Sympathetic Nervous System Summit
Kiuchi, M. G., Esler, M., Fink, G. D., Osborn, J. W., Banek, C. T., Böhm, M., Denton, K. M., DiBona, G. F., Everett, T. H., Grassi, G. M., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.015 · Cited by 103 · see citing works
Lupus nephritis-related chronic kidney disease
Lichtnekert, J., & Anders, H. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01158-w · Cited by 102 · see citing works
Oxidative Stress in Kidney Injury and Hypertension
Arendshorst, W. J., Vendrov, A. E., Kumar, N., Ganesh, S. K., & Madamanchi, N. R. (2024) · Antioxidants · doi:10.3390/antiox13121454 · Cited by 103 · see citing works
Self-citationCarlström, M., & Montenegro, M. F. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12818 · Cited by 97 · see citing works
Self-citationRenal dysfunction in cardiovascular diseases and its consequences
Deferrari, G., Cipriani, A., & Porta, E. L. (2020) · Journal of Nephrology · doi:10.1007/s40620-020-00842-w · Cited by 97 · see citing works
Autoregulation and neurovascular coupling in the optic nerve head
Prada, D., Harris, A., Guidoboni, G., Siesky, B. A., Huang, A. M., & Arciero, J. C. (2015) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2015.10.004 · Cited by 96 · see citing works
Ravindran, S., & Munusamy, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30621 · Cited by 96 · see citing works
Extracellular Nucleotides and P2 Receptors in Renal Function
Vallon, V., Unwin, R. J., Inscho, E. W., Leipziger, J., & Kishore, B. K. (2019) · Physiological Reviews · doi:10.1152/physrev.00038.2018 · Cited by 92 · see citing works
Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis
Kriz, W., & Lemley, K. V. (2016) · Pediatric Nephrology · doi:10.1007/s00467-016-3358-9 · Cited by 87 · see citing works
Promise of SGLT2 Inhibitors in Heart Failure: Diabetes and Beyond
Martens, P., Mathieu, C., & Verbrugge, F. H. (2017) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-017-0522-x · Cited by 86 · see citing works
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate
Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 86 · see citing works
Self-citationRenal blood flow and oxygenation
Edwards, A., & Kurtcuoglu, V. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02690-y · Cited by 85 · see citing works
Ion channels and channelopathies in glomeruli
Staruschenko, A., Ma, R., Palygin, O., & Dryer, S. E. (2022) · Physiological Reviews · doi:10.1152/physrev.00013.2022 · Cited by 84 · see citing works
Wang, Z., do Carmo, J. M., Aberdein, N., Zhou, X., Williams, J. M., da Silva, A. A., & Hall, J. E. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08560 · Cited by 84 · see citing works
Novel Paradigms of Salt and Hypertension
Feng, W., Dell’Italia, L. J., & Sanders, P. W. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016080927 · Cited by 83 · see citing works
Role of perioperative hypotension in postoperative acute kidney injury: a narrative review
Lankadeva, Y. R., May, C. N., Bellomo, R., & Evans, R. G. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.03.002 · Cited by 79 · see citing works
New insights on glomerular hyperfiltration: a Japanese autopsy study
Kanzaki, G., Puelles, V. G., Cullen‐McEwen, L. A., Hoy, W. E., Okabayashi, Y., Tsuboi, N., Shimizu, A., Denton, K. M., Hughson, M. D., Yokoo, T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.94334 · Cited by 78 · see citing works
Microvascular endothelial dysfunction is associated with albuminuria
Martens, R. J. H., Houben, A. J. H. M., Kooman, J. P., Berendschot, T. T. J. M., Dagnelie, P. C., Kallen, C., Kroon, A. A., Leunissen, K. M. L., SANDE, F. M. V. D., Schaper, N. C., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001674 · Cited by 75 · see citing works
Stem Cells for Next Level Toxicity Testing in the 21st Century
Fritsche, E., Haarmann‐Stemmann, T., Kapr, J., Galanjuk, S., Hartmann, J., Mertens, P. R., Kämpfer, A. A. M., Schins, R. P. F., Tigges, J., & Koch, K. (2020) · Small · doi:10.1002/smll.202006252 · Cited by 75 · see citing works
Mechanisms of triple whammy acute kidney injury
Prieto-García, L., Pericacho, M., Sancho‐Martínez, S. M., Sánchez, Á., Martínez‐Salgado, C., López-Novoa, J. M., & López-Hernández, F. J. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.011 · Cited by 75 · see citing works
Hezel, M. P., Peleli, M., Liu, M. R., Zollbrecht, C., Jensen, B. L., Checa, A., Giulietti, A., Wheelock, C. E., Lundberg, J. O., Weitzberg, E., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.025 · Cited by 73 · see citing works
Self-citationAssociations Between Life's Essential 8 and Chronic Kidney Disease
Ren, Y., Cai, Z., Guo, C., Zhang, Y., Xu, H., Liu, L., Wang, L., Ba, Y., Liu, S., Zhang, G., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.030564 · Cited by 73 · see citing works
Ma, Q., Steiger, S., & Anders, H. (2017) · Physiological Reports · doi:10.14814/phy2.13228 · Cited by 73 · see citing works
Gustot, T., Stadlbauer, V., Laleman, W., Alessandria, C., & Thursz, M. R. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.12.005 · Cited by 71 · see citing works
Device-Based Neuromodulation for Resistant Hypertension Therapy
Lohmeier, T. E., & Hall, J. E. (2019) · Circulation Research · doi:10.1161/circresaha.118.313221 · Cited by 71 · see citing works
Glucagon-like peptide-1 receptors in the kidney: impact on renal autoregulation
Hviid, A. V. R., & Sørensen, C. M. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00280.2019 · Cited by 69 · see citing works
Microvascular dysfunction and kidney disease: Challenges and opportunities?
Krishnan, S., Suarez‐Martinez, A. D., Bagher, P., Gonzalez, A. L., Liu, R., Murfee, W. L., & Mohandas, R. (2020) · Microcirculation · doi:10.1111/micc.12661 · Cited by 67 · see citing works
Nephron overload as a therapeutic target to maximize kidney lifespan
Luyckx, V. A., Rule, A. D., Tuttle, K. R., Delanaye, P., Liapis, H., Gandjour, A., Romagnani, P., & Anders, H. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00510-7 · Cited by 66 · see citing works
Practical approach to detection and management of acute kidney injury in critically ill patient
Mohsenin, V. (2017) · Journal of Intensive Care · doi:10.1186/s40560-017-0251-y · Cited by 65 · see citing works
Systolic Blood Pressure Time in Target Range and Major Adverse Kidney and Cardiovascular Events
Buckley, L. F., Baker, W. L., Tassell, B. W. V., Cohen, J. B., Alkhezi, O. S., Bress, A. P., & Dixon, D. L. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.20141 · Cited by 64 · see citing works
Arterial Pressure and the Rate of Elimination of Crystalloid Fluid
Hahn, R. G. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002075 · Cited by 64 · see citing works
Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications
Zhao, Y., Pu, M., Wang, Y., Yu, L., Song, X., & He, Z. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.026 · Cited by 62 · see citing works
Diabetic Proteinuria Revisited: Updated Physiologic Perspectives
Heyman, S. N., Raz, I., Dwyer, J. P., Sibony, R. W., Lewis, J. B., & Abassi, Z. A. (2022) · Cells · doi:10.3390/cells11182917 · Cited by 62 · see citing works
Collard, D., Brouwer, T. F., Engberink, R. O., Zwinderman, A. H., Vogt, L., & van den Born, B. H. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14659 · Cited by 62 · see citing works
Renal Microcirculation Injury as the Main Cause of Ischemic Acute Kidney Injury Development
Kwiatkowska, E., Kwiatkowski, S., Dziedziejko, V., Tomasiewicz, I., & Domański, L. (2023) · Biology · doi:10.3390/biology12020327 · Cited by 60 · see citing works
Reactive oxygen species in renal vascular function
Xu, N., Jiang, S., Persson, P. B., Persson, E. A. G., Lai, E. Y., & Patzak, A. R. (2020) · Acta Physiologica · doi:10.1111/apha.13477 · Cited by 58 · see citing works
Adenosine signaling in diabetes mellitus and associated cardiovascular and renal complications
Peleli, M., & Carlström, M. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.12.001 · Cited by 58 · see citing works
Self-citationTubular injury triggers podocyte dysfunction by β-catenin–driven release of MMP-7
Tan, R. J., Li, Y., Rush, B. M., Cerqueira, D. M., Zhou, D. F., Fu, H., Ho, J., Stolz, D. B., & Liu, Y. (2019) · JCI Insight · doi:10.1172/jci.insight.122399 · Cited by 57 · see citing works
Anders, H., Peired, A. J., & Romagnani, P. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa329 · Cited by 56 · see citing works
How should we assess renal function in neonates and infants?
Filler, G., Bhayana, V., Schott, C., & Ferris, M. (2020) · Acta Paediatrica · doi:10.1111/apa.15557 · Cited by 53 · see citing works
Castro, P., Azevedo, E. I., Rocha, I., Sorond, F. A., & Serrador, J. M. (2018) · BMC Neurology · doi:10.1186/s12883-018-1025-4 · Cited by 50 · see citing works
Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms
Li, X., Yuan, F., & Zhou, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226637 · Cited by 49 · see citing works
Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Non-Diabetic Chronic Kidney Disease
Mima, A. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01735-5 · Cited by 49 · see citing works
Lang, S. T., Guo, J., Bruns, A., Dürr, M., Braun, J., Hamm, B., Sack, I., & Garcia, S. R. M. (2019) · Investigative Radiology · doi:10.1097/rli.0000000000000585 · Cited by 48 · see citing works
Renal autoregulation and blood pressure management in circulatory shock
Post, E. H., & Vincent, J. (2018) · Critical Care · doi:10.1186/s13054-018-1962-8 · Cited by 47 · see citing works
The Gomez equations and renal hemodynamic function in kidney disease research
Bjornstad, P., Škrtić, M., Lytvyn, Y., Maahs, D. M., Johnson, R. J., & Cherney, D. Z. I. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00415.2016 · Cited by 46 · see citing works
Garcia, S. R. M., Großmann, M., Lang, S. T., Tzschätzsch, H., Dittmann, F., Hamm, B., Braun, J., Guo, J., & Sack, I. (2017) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26892 · Cited by 46 · see citing works
Dynamics of Cerebral Blood Flow in Patients with Mild Non-Ischaemic Heart Failure
Erkelens, C. D., van der Wal, H. H., de Jong, B. M., Elting, J. J., Renken, R. J., Gerritsen, M. J. J., van Laar, P. J., van Deursen, V. M., van der Meer, P., van Veldhuisen, D. J., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.660 · Cited by 45 · see citing works
Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets
Zhong, S., Wang, N., & Zhang, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169035 · Cited by 43 · see citing works
CD39-adenosinergic axis in renal pathophysiology and therapeutics
Kishore, B. K., Robson, S. C., & Dwyer, K. M. (2018) · Purinergic Signalling · doi:10.1007/s11302-017-9596-x · Cited by 42 · see citing works
Reconsidering Vasopressors for Cardiogenic Shock
Squara, P., Hollenberg, S. M., & Payen, D. M. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.03.020 · Cited by 42 · see citing works
Mechanisms of blood pressure salt sensitivity: new insights from mathematical modeling
Clemmer, J. S., Pruett, W. A., Coleman, T. G., Hall, J. E., & Hester, R. L. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00353.2016 · Cited by 41 · see citing works
Bahadoran, Z., Mirmiran, P., Ghasemi, A., Carlström, M., Azizi, F., & Hadaegh, F. (2016) · Nutrients · doi:10.3390/nu8120811 · Cited by 41 · see citing works
Self-citationRenin Cells, From Vascular Development to Blood Pressure Sensing
Yamaguchi, H., Gómez, R. A., & Sequeira-Lόpez, M. L. S. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.20577 · Cited by 40 · see citing works
Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System
Zatz, R., & Nucci, G. D. (2023) · Physiology · doi:10.1152/physiol.00020.2023 · Cited by 40 · see citing works
Arterial Myogenic Activation through Smooth Muscle Filamin A
Retailleau, K., Arhatte, M., Demolombe, S., Peyronnet, R., Baudrie, V., Jodar, M., Bourreau, J., Henrion, D., Offermanns, S., Nakamura, F., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.019 · Cited by 40 · see citing works
Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review
Moreira, R. P., & Muscelli, E. (2020) · Journal of Diabetes Research · doi:10.1155/2020/8492467 · Cited by 40 · see citing works
Lee, B. S., Holstein‐Rathlou, N., Sosnovtseva, O. V., & Sørensen, C. M. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00147.2023 · Cited by 39 · see citing works
Fan, F., Pabbidi, M. R., Ge, Y. C., Li, L., Wang, S., Mims, P. N., & Roman, R. J. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00529.2016 · Cited by 39 · see citing works
Wang, Y., Shi, J., & Tong, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168782 · Cited by 39 · see citing works
Staplin, N., Herrington, W. G., Murgia, F., Ibrahim, M. A.-H., Bull, K. R., Judge, P. K., Ng, S. Y. A., Turner, M., Zhu, D., Emberson, J., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19354 · Cited by 38 · see citing works
Qin, L., Zhao, Y., Zhang, B., & Li, Y. (2017) · Food & Function · doi:10.1039/c7fo01095h · Cited by 38 · see citing works
Mewton, N., Girerd, N., Boffa, J., Courivaud, C., Isnard, R., Juillard, L., Lamblin, N., Legrand, M. M., Logeart, D., Mariat, C., et al. (2020) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2020.03.018 · Cited by 38 · see citing works
Renovascular remodeling and renal injury after extended angiotensin II infusion
Casare, F. A. M., Thieme, K., Costa-Pessoa, J. M., Rossoni, L. V., Couto, G. K., Fernandes, F. B., Casarini, D. E., & Oliveira‐Souza, M. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00471.2015 · Cited by 37 · see citing works
Future Considerations in Nocturia and Nocturnal Polyuria
Weiss, J. P., Monaghan, T. F., Epstein, M. R., & Lazar, J. (2019) · Urology · doi:10.1016/j.urology.2019.06.014 · Cited by 37 · see citing works
Rho GTPases in kidney physiology and diseases
Steichen, C., Hervé, J. C., Hauet, T., & Bourmeyster, N. (2021) · Small GTPases · doi:10.1080/21541248.2021.1932402 · Cited by 37 · see citing works
Hypoxia and Renal Tubulointerstitial Fibrosis
Li, Z., & Liu, B. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8871-2_23 · Cited by 36 · see citing works
Anemia and Hypoxia Impact on Chronic Kidney Disease Onset and Progression: Review and Updates
Habas, E. M., Adab, A. A., Arryes, M., Alfitori, G. B., Farfar, K. L., Habas, A. M., Akbar, R. A., Rayani, A., Habas, E., & Elzouki, A. (2023) · Cureus · doi:10.7759/cureus.46737 · Cited by 35 · see citing works
Yang, T., Zollbrecht, C., Winerdal, M. E., Zhuge, Z., Zhang, X., Terrando, N., Checa, A., Sällström, J., Wheelock, C. E., Winqvist, O., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003868 · Cited by 35 · see citing works
Self-citationThe nephron-arterial network and its interactions
Marsh, D. J., Postnov, D. D., Sosnovtseva, O. V., & Holstein‐Rathlou, N. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00484.2018 · Cited by 35 · see citing works
SGLT2 inhibitors – a potential treatment for Alport syndrome
Mabillard, H. R., & Sayer, J. A. (2020) · Clinical Science · doi:10.1042/cs20191276 · Cited by 35 · see citing works
Groß, O., Boeckhaus, J., Weber, L. T., Heerspink, H. J. L., Simon, J. F., Ahmed, R., Gerst, C., Duerr, U., Walker, F., Tostmann, R., et al. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae180 · Cited by 34 · see citing works
Genetic susceptibility of hypertension‐induced kidney disease
Zhang, C., Fang, X., Zhang, H., Gao, W., Hsu, H. J., Roman, R. J., & Fan, F. (2020) · Physiological Reports · doi:10.14814/phy2.14688 · Cited by 34 · see citing works
Li, L., Lai, E. Y., Wellstein, A., Welch, W. J., & Wilcox, C. S. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00575.2015 · Cited by 34 · see citing works
Self-citation
- Authors
- Carlström, M., Wilcox, C. S., & Arendshorst, W. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2015-04
- Volume
- 95
- Issue
- 2
- Pages
- 405-511
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC4551215
- OpenAlex
- W2078902399
- Cited by
- 485
- References
- 1,700
- Citations by year
- 2026: 44 · 2025: 40 · 2024: 40 · 2023: 47 · 2022: 41 · 2021: 37 · 2020: 41 · 2019: 53 · 2018: 50 · 2017: 51 · 2016: 31 · 2015: 9 · 2014: 1
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL‐68686, P01HL068686, R01HL002334, HL 02334)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK109272, DK-049870, DK-036079, R01DK049870)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Keywords
- renal autoregulation, renal blood flow, glomerular filtration rate, myogenic response, tubuloglomerular feedback, macula densa, afferent arteriole, mechanotransduction, calcium signaling, ryanodine receptor, protein kinase C, Rho/ROCK signaling, myosin light chain kinase, reactive oxygen species, nitric oxide, kidney disease
- MeSH terms
- Animals, Diabetic Nephropathies, Glomerular Filtration Rate, Homeostasis, Humans, Hypertension, Kidney, Muscle, Smooth, Vascular, Renal Artery, Renal Circulation, Vasoconstriction, Calcium Channels, Calcium Signaling, Mechanotransduction, Cellular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
