Oxidative stress in chronic kidney disease

Ling, Xiao Chun; Kuo, Ko-Lin

doi:10.1186/s41100-018-0195-2

Cited by 183Antioxidant Activity and Oxidative StressDialysis and Renal Disease ManagementChronic Kidney Disease and Diabetes

Oxidative stress in chronic kidney disease

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Ling, Xiao Chun, Kuo, Ko-Lin·2018·Renal Replacement Therapy

DOI 10.1186/s41100-018-0195-2

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Abstract

For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovascular disease. One of the main novel risk factors is oxidative stress, which occurs when there is overproduction of reactive oxygen species (ROS) and/or a reduction in antioxidant defense capacity. Oxidative stress is involved in the progression of renal injury, pathogenesis of atherosclerosis, and exacerbation of disease burden in CKD patients. In addition, uremic- and dialysis-associated factors in these patients further contribute to oxidative stress via a proinflammatory state, including exposure to dialysate endotoxins or the use of bioincompatible hemodialysis dialyzer membranes. Consequences of oxidative stress in CKD patients include atherosclerosis, amyloidosis, and anemia. Strategies to combat oxidative stress include antioxidant therapies such as vitamins C and E or N -acetylcysteine (NAC). While these antioxidant strategies are promising, few interventional studies have examined their effects until now. In light of the disparate experimental and clinical data, large, randomized, long-term studies are required to establish their efficacy and safety in CKD patients.

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Oxidative stress in chronic kidney diseases is characterized by ROS-mediated oxidative stress, RNS-mediated nitrosative stress, chlorinated stress, and carbonyl stress.
“Oxidative stress in chronic kidney diseases is characterized by several distinct pathways: oxidative stress mediated by ROS (·OH), nitrosative stress mediated by RNS (ONOO−, ·NO2), chlorinated stress mediated by chlorinated species (HOCl), and carbonyl stress (Advanced glycation end products, AGEs) (Ling and Kuo 2018).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ling and Kuo 2018

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Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients
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Iron Sucrose Accelerates Early Atherogenesis by Increasing Superoxide Production and Upregulating Adhesion Molecules in CKD
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Increased Oxidative Damage to Peripheral Blood Leukocyte DNA in Chronic Peritoneal Dialysis Patients
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Oxidative Balance Score and Chronic Kidney Disease
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Increase in Resting Levels of Superoxide Anion in the Whole Blood of Uremic Patients on Chronic Hemodialysis
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N-acetylcysteine on oxidative damage in diabetic rats
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Profiling the proteome in renal transplantation
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Inhibition of the Renin-Angiotensin System Abolishes the Proatherogenic Effect of Uremia in Apolipoprotein E-Deficient Mice
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Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis
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Influence of Hemodialysis on Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidant Capacity in Chronic Renal Failure Patients
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Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase (−/−) mice and improved by combined administration of L‐arginine and antioxidants
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Monocytes from Dialysis Patients Exhibit Characteristics of Senescent Cells: Does It Really Mean Inflammation?
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases
Kowalczyk, P., Sulejczak, D., Kleczkowska, P., Bukowska‐Ośko, I., Kucia, M., Popiel, M., Wietrak, E., Kramkowski, K., Wrzosek, K., & Kaczyńska, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413384 · Cited by 528 · see citing works
Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation
Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137273 · Cited by 510 · see citing works
Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
Tirichen, H., Yaigoub, H., Xu, W., Wu, C., Li, R., & Li, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.627837 · Cited by 431 · see citing works
Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease
Podkowińska, A., & Formanowicz, D. (2020) · Antioxidants · doi:10.3390/antiox9080752 · Cited by 378 · see citing works
Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis Patients
Ebert, T., Neytchev, O., Witasp, A., Kublickiene, K. R., Stenvinkel, P., & Shiels, P. G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8184 · Cited by 190 · see citing works
Uremic Toxins and Their Relation with Oxidative Stress Induced in Patients with CKD
Pieniążek, A., Bernasinska-Slomczewska, J., & Gwoździński, Ł. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126196 · Cited by 116 · see citing works
Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography
Nuhu, F., Gordon, A. D., Sturmey, R. G., Seymour, A. L., & Bhandari, S. (2020) · Molecules · doi:10.3390/molecules25184196 · Cited by 105 · see citing works
Kynurenine Pathway in Chronic Kidney Disease: What’s Old, What’s New, and What’s Next?
Mor, A., Kałaska, B., & Pawlak, D. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920954882 · Cited by 74 · see citing works
Mitochondrial Pathophysiology on Chronic Kidney Disease
Braga, P. C., Alves, M. G., Rodrigues, A. S., & Oliveira, P. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031776 · Cited by 69 · see citing works
Polyphenols and Their Metabolites in Renal Diseases: An Overview
Guerreiro, I., Ferreira‐Pêgo, C., Carregosa, D., dos Santos, C. N., Menezes, R., Fernandes, A. S., & Costa, J. G. (2022) · Foods · doi:10.3390/foods11071060 · Cited by 64 · see citing works
Role of oxidative stress on chronic kidney disease progression.
Putri, A. Y., & Thaha, M. (2014) · Acta medica Indonesiana · Cited by 58 · see citing works
Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism
Petrulea, M. S., Mureșan, A., & Dunce, I. (2012) · InTech eBooks · doi:10.5772/51018 · Cited by 54 · see citing works
Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases
Bollenbecker, S., Czaya, B. A., Gutiérrez, O. M., & Krick, S. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00152.2021 · Cited by 53 · see citing works
Oxidative Stress in Patients with Advanced CKD and Renal Replacement Therapy: The Key Role of Peripheral Blood Leukocytes
Vida, C., Oliva, C., Yuste, C., Ceprián, N., Jara, P., Valera, G., de Pablos, I. G., Morales, E., & Carracedo, J. (2021) · Antioxidants · doi:10.3390/antiox10071155 · Cited by 47 · see citing works
Linking chronic kidney disease and Parkinson’s disease: a literature review
Meléndez-Flores, J. D., & Estrada-Bellmann, I. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-020-00623-1 · Cited by 44 · see citing works
Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis
Fazelian, S., Moradi, F., Agah, S., Hoseini, A., Heydari, H., Morvaridzadeh, M., Omidi, A., Pizarro, A. B., Ghafouri, A., & Heshmati, J. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02351-9 · Cited by 45 · see citing works
The Effect of Metformin in Diabetic and Non-Diabetic Rats with Experimentally-Induced Chronic Kidney Disease
Za’abi, M. A., Ali, B. H., Suleimani, Y. M. A., Adham, S. A., Ali, H. A., Manoj, P., Ashique, M., & Nemmar, A. (2021) · Biomolecules · doi:10.3390/biom11060814 · Cited by 44 · see citing works
Iron and bones: effects of iron overload, deficiency and anemia treatments on bone
von Brackel, F. N., & Oheim, R. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae064 · Cited by 51 · see citing works
Prospects for Protective Potential of Moringa oleifera against Kidney Diseases
Akter, T., Rahman, M. A., Moni, A., Apu, M. A. I., Fariha, A., Hannan, M. A., & Uddin, M. J. (2021) · Plants · doi:10.3390/plants10122818 · Cited by 43 · see citing works
Role of Polyphenol in Regulating Oxidative Stress, Inflammation, Fibrosis, and Apoptosis in Diabetic Nephropathy
Sapian, S., Budin, S. B., Taib, I. S., Mariappan, V., Zainalabidin, S., & Chin, K. (2021) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530321666211119144309 · Cited by 38 · see citing works
Chronic Kidney Disease—Effect of Oxidative Stress
Sundaram, S. P. M., Nagarajan, S., & Devi, A. J. M. (2014) · Chinese Journal of Biology · doi:10.1155/2014/216210 · Cited by 38 · see citing works
Retracted
Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
Adhikari, A., Mondal, S., Chatterjee, T., Das, M., Biswas, P., Ghosh, R., Darbar, S., Alessa, H., Althakafy, J. T., Sayqal, A. A., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02546-8 · Cited by 37 · see citing works
The Role of Eryptosis in the Pathogenesis of Renal Anemia: Insights From Basic Research and Mathematical Modeling
Dias, G. F., Grobe, N., Rogg, S., Jörg, D. J., Pecoits‐Filho, R., Moreno-Amaral, A. N., & Kotanko, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.598148 · Cited by 36 · see citing works
Polyphenolic compounds of amla prevent oxidative stress and fibrosis in the kidney and heart of 2K1C rats
Rahman, M. M., Ferdous, K. U., Roy, S., Nitul, I. A., Mamun, F., Hossain, H., Subhan, N., Alam, M. A., & Haque, M. A. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1640 · Cited by 36 · see citing works
Effect of Omega-3 Fatty Acids on Serum Lipid Profile and Oxidative Stress in Pediatric Patients on Regular Hemodialysis: A Randomized Placebo-Controlled Study
Ateya, A. M., Sabri, N. A., Hakim, I. Z. E., & Shaheen, S. M. (2017) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2016.11.005 · Cited by 30 · see citing works
Could grape-based food supplements prevent the development of chronic kidney disease?
Zhu, J., & Du, C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676195 · Cited by 30 · see citing works
Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Perspectives
Anwar, S., Alharbi, H., Babiker, A., & Rahmani, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062681 · Cited by 35 · see citing works
The Therapeutic Strategies for Uremic Toxins Control in Chronic Kidney Disease
Lu, P., Yu, M., Wei, M.-J., & Kuo, K. (2021) · Toxins · doi:10.3390/toxins13080573 · Cited by 29 · see citing works
Self-citation
Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4
Amador‐Martínez, I., Aparicio‐Trejo, O. E., Bernabe-Yepes, B., Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Sánchez‐Lozada, L. G., Pedraza‐Chaverrí, J., & Tapia, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115875 · Cited by 28 · see citing works
Association between anemia and hyperuricemia: results from the Korean National Health and Nutrition Examination Survey
Eun, Y., Han, K., Kim, D. H., Kim, I. Y., Park, E., Lee, S., Cha, H., Koh, E., Lee, J., & Kim, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-55514-y · Cited by 27 · see citing works
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury
Liu, M., Zheng, B., Liu, P., Zhang, J., Chu, X., Dong, C., Shi, J., Liang, Y., Chu, L., Liu, Y., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12077 · Cited by 31 · see citing works
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Authors: Ling, X. C., & Kuo, K.-L.
Affiliations: Taipei Medical University (TW)
Tzu Chi University (TW)
Corresponding author: Kuo, Ko-Lin
ORCID: Ling, Xiao Chun
Kuo, Ko-Lin
Venue: Renal Replacement Therapy
Publisher: Springer Science and Business Media LLC
Published: 2018-12
Volume: 4
Issue: 1
ISSN: 2059-1381 (ISSN-L)
DOI: 10.1186/s41100-018-0195-2
OpenAlex: W2271595134
Cited by: 183
References: 133
Citations by year: 2026: 21 · 2025: 33 · 2024: 20 · 2023: 25 · 2022: 26 · 2021: 30 · 2020: 15 · 2019: 7 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2012: 1
FWCI: 9.08
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Renal Replacement Therapy (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministry of Science and Technology, R.O.C. (MOST 105-2314-B-303-013-MY3)
Taipei Tzu Chi Hospital (TCRD-TPE-107-24)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: oxidative stress, chronic kidney disease, reactive oxygen species, antioxidant defense, cardiovascular risk, atherosclerosis, uremic toxins, endotoxin, amyloidosis, anemia, antioxidant therapy, N-acetylcysteine, vitamins C and E

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